Measurement of intratumor pH by pH indicator used in 19F-magnetic resonance spectroscopy: Measurement of extracellular pH decrease caused by hyperthermia combined with hydralazine

Investigative Radiology

Volumn 31, Issue 11, 1996, Pages 680-689

  Aoki, Yoshizumi ^a   Akagi, Kiyoshi ^a   Tanaka, Yoshimasa ^a   Kawai, Jun ^b   Takahashi, Masaya ^b  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b Nihon Schering KK   (Japan)

Author keywords

19F magnetic resonance spectroscopy; experimental tumor; heating; pH

Indexed keywords

FLUORINE; FLUORINE DERIVATIVE; HYDRALAZINE; UNCLASSIFIED DRUG; ZK 150471;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CONTROLLED STUDY; EXPERIMENTAL NEOPLASM; HYPERTHERMIC THERAPY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH ELECTRODE; PH MEASUREMENT; PRIORITY JOURNAL;

EID: 0029952978     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199611000-00002     Document Type: Article

References (36)

1. O'Donnell T. Measurement of percutaneous muscle surface pH. Lancet 1975;2:533.
2. Kim GE, Lyons JC, Song CW. Effects of amiloride on intracellular pH and thermosensitivity. Int J Radiat Oncol Biol Phys 1991;20:541-549.
3. 31P-MRS. J Biol Chem 1973;248:7276-7278.
4. 19F-MRS. Ann NY Acad Science 1987;508:33-47.
5. 31P-NMR analysis. Am J Physiology 1984;247:C506-C510.
6. 19F-NMR indicators of intracellular pH. Biophysical J 1983;43: 261-267.
7. Rhee JG, Kim TH, Levitt SH, Song CW. Changes in acidity of mouse tumor by hyperthermia. Int J Radiat Oncol Biol Phys 1984;10:393-399.
8. Song CW, Lyons JC, Makepeace CM, Griffin RJ, Cragoe EJ Jr. Effects of HMA, an analog of amiloride, on the thermosensitivity of tumors in vivo. Int J Radiat Oncol Biol Phys 1994;30: 133-139.
9. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen, and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 1989;49:6449-6465.
10. Song CW. Effect of local hyperthermia on blood flow and microenvironment: A review. Cancer Res 1984;44:4721S-4730S.
11. Emami B, Song CW. Physiological mechanisms in hyperthermia: A review. Int J Radiat Oncol Biol Phys 1984;10:289-295.
12. Hall EJ, Roizin-Towle L. Biological effects of heat. Cancer Res 1984;44:4708S-4713S.
13. Jaehde E, Rajewsky MF. Tumor-selective modification of cellular microenvironment in vivo: Effect of glucose infusion on the pH in normal and malignant rat tissues. Cancer Res 1982;42:1505-1512.
14. Tobari C, Kersen IV, Hahn GM. Modification of pH of normal and malignamt mouse tissue by hydralazine and glucose, with and without breathing of 5% CO2 and 95% air. Cancer Res 1988;48:1543-1547.
15. 31P-nuclear magnetic resonance spectroscopy. J Natl Cancer Inst 1988;80:745-750.
16. 19F-magnetic resonance spectroscopy. SMRM 1992;3413. Abstract.
17. Freeman ML, Raaphorst GP, Hopwood LE, Dewey WC. The effect of cell lethality induced by hyperthermic treatment. Cancer 1980;45:2291-2300.
18. 19F nuclear magnetic resonance spectroscopy. Cancer Res 1991;51: 5770-5773.
19. Teicher BA, Herman TS, Holden SA, Rudolph MB. Effect of oxygenation, pH, and hyperthermia on RSU-1069 in vitro and in vivo with radiation in the FSaIIC murine fibrosarcoma. Cancer Lett 1991;59:109-117.
20. Herman TS, Teicher BA, Pfeffer MR, Khandekar VS, Korbut TT. Interaction with hyperthermia of tetrachloroplatinum (II) (Nile blue) 2 and tetrachloroplatinum (II) (neutral red) 2 in EMT6 murine cells and the murine FSaIIC fibrosarcoma. Cancer Res 1990;50:3826-3831.
21. Gennis RB. Biomembranes: moleculler structure and function. New York: Springer Verlag Inc. 1989;216:214.
22. Watson JD. Molecular biology of the cell. 3rd edition. New York, NY: Garland Publishing, Inc., 1994.
23. Varnes ME, Menegay HJ, Mckenna DS. Inhibition of recovery from potentially lethal radiation damage in A549 cells by the K+/H+ ionophore nigericin. Int J Radiat Oncol Biol Phys 1991;20:281-285.
24. Schatten G, Bester T, Henson B. Intracellular pH shift initiates microtubule mediated motility during sea urchin fertilization. Ann Acad Science NY 1986;466:940-942.
25. Song CW, Kang MS, Rhee JG, Levin SH. The effect of hyperthermia on vascular function, pH, and cell survival. Radiology 1980;137:795-803.
26. Thistlethwaite AJ, Leeper DB, Moylan DJ 3d, Nerlinger RE. pH distribution in human tumors. Int J Radiat Oncol Biol Phys 1985;11:1647-1652.
27. Hetzel FW, Avery K, Chopp M. Hyperthermic "dose" dependent changes in intralesional pH. Int J Radiat Oncol Biol Phys 1989;16:183-186.
28. Hetzel FW, Chopp M. Changes in muscle pH following hyperthermia. Radiat Res 1990;122:229-233.
29. Rockwell S, Hughes CS, Kennedy KA. Effect of host age on microenvironmental heterogeneity and efficacy of combined modality therapy in solid tumors. Int J Radiat Oncol Biol Phys 1991;19:259-263.
30. Bicher HI, Hetzel FW, Sandhu TS, et al. Effect of hyperthermia on normal and tumor microenvironment. Radiology 1980;137: 523-530.
31. 19F- pH indicators: Fluoroanilines. Biophys J 1989;55:799-804.
32. Ganong WF. Review of medical physiology. 16th ed. Connecticut: Lange, 1994.
33. 31P-NMR spectroscopy of murine tumors before and after localized hyperthermia. Int J Hyperthermia 1990;6:15-31.
34. 31P-NMR spectroscopy. J Radiation Res 1994;35:65-73.
35. 13C-NMR spectroscopy. Am J Physiology 1993;264:C755-C760.
36. van de Merwe SA, van den Berg AP, van der Zee J, Reinhold HS. Measurement of tumor pH during microwave induced experimental and clinical hyperthermia with a fiber optic pH measurement system. Int J Radial Oncol Biol Phys 1990;18:51-57.