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Volumn 98, Issue 1, 2001, Pages 65-73

Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine β-major and β-minor globin genes

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; DNA; HEMOGLOBIN; KANAMYCIN KINASE; RNA;

EID: 0035412354     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.1.65     Document Type: Article
Times cited : (5)

References (42)
  • 1
    • 0002398438 scopus 로고
    • Hemoglobin switching
    • Stamatoyannopoulos G, Nienhuis AW, Majerus PW, Varmus H, eds. Philadelphia: WB Saunders
    • Stamatoyannopoulos G, Nienhuis AW. Hemoglobin switching. In: Stamatoyannopoulos G, Nienhuis AW, Majerus PW, Varmus H, eds. The Molecular Basis of Blood Diseases. 2nd ed. Philadelphia: WB Saunders; 1994:107-155.
    • (1994) The Molecular Basis of Blood Diseases. 2nd ed. , pp. 107-155
    • Stamatoyannopoulos, G.1    Nienhuis, A.W.2
  • 2
    • 0034624971 scopus 로고    scopus 로고
    • Gene therapy for the hemoglobin disorders: Past, present, and future
    • Persons DA, Nienhuis AW. Gene therapy for the hemoglobin disorders: past, present, and future. Proc Natl Acad Sci U S A. 2000;97:5022-5024.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5022-5024
    • Persons, D.A.1    Nienhuis, A.W.2
  • 4
    • 0026666055 scopus 로고
    • Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells
    • Van Beusechem VM, Kukler A, Heidt PJ, Valerio D. Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells. Proc Natl Acad Sci U S A. 1992;89:7640-7644.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 7640-7644
    • Van Beusechem, V.M.1    Kukler, A.2    Heidt, P.J.3    Valerio, D.4
  • 5
    • 0028062923 scopus 로고
    • Retroviral vector sequences inhibit human β-globin gene expression in transgenic mice
    • McCune SL, Townes TM. Retroviral vector sequences inhibit human β-globin gene expression in transgenic mice. Nucleic Acids Res. 1994;22:4477-4481.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4477-4481
    • McCune, S.L.1    Townes, T.M.2
  • 6
    • 0031949085 scopus 로고    scopus 로고
    • Genetic treatment of severe hemoglobinopathies: The combat against transgene variegation and transgene silencing
    • Rivella S, Sadelain M. Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing, Semin Hematol. 1998;35:112-125.
    • (1998) Semin Hematol , vol.35 , pp. 112-125
    • Rivella, S.1    Sadelain, M.2
  • 7
    • 0025295890 scopus 로고
    • High-level beta-globin expression after transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells
    • Novak U, Harris EA, Forrester W, Groudine M, Gelinas R. High-level beta-globin expression after transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1990;87:3386-3390.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 3386-3390
    • Novak, U.1    Harris, E.A.2    Forrester, W.3    Groudine, M.4    Gelinas, R.5
  • 8
    • 0027534432 scopus 로고
    • A human β-globin gene fused to the human β-globin locus control region is expressed at high levels in erythroid cells of mice engrafted with retrovirus-transduced hematopoietic stem cells
    • Plavec I, Papayannopoulou T, Maury C, Meyer F, A human β-globin gene fused to the human β-globin locus control region is expressed at high levels in erythroid cells of mice engrafted with retrovirus-transduced hematopoietic stem cells. Blood. 1993;81:1384-1392.
    • (1993) Blood , vol.81 , pp. 1384-1392
    • Plavec, I.1    Papayannopoulou, T.2    Maury, C.3    Meyer, F.4
  • 9
    • 0029084785 scopus 로고
    • Generation of a high-titer retroviral vector capable of expressing high levels of the human β-globin gene
    • Sadelain M, Wang CH, Antoniou M, Grosveld F, Mulligan RC. Generation of a high-titer retroviral vector capable of expressing high levels of the human β-globin gene. Proc Natl Acad Sci U S A. 1995;92:6728-6732,
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6728-6732
    • Sadelain, M.1    Wang, C.H.2    Antoniou, M.3    Grosveld, F.4    Mulligan, R.C.5
  • 10
    • 0343628721 scopus 로고    scopus 로고
    • Therapeutic haemoglobin synthesis in β-thalassemia mice expressing lentivirus-encoded human β-globin
    • May C, Rivella S, Callegari J, et al. Therapeutic haemoglobin synthesis in β-thalassemia mice expressing lentivirus-encoded human β-globin. Nature. 2000;406:82-85.
    • (2000) Nature , vol.406 , pp. 82-85
    • May, C.1    Rivella, S.2    Callegari, J.3
  • 11
    • 0029817766 scopus 로고    scopus 로고
    • Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide
    • Cole-Strauss A, Yoon K, Xiang Y, et al. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science, 1996;273:1386-1389.
    • (1996) Science , vol.273 , pp. 1386-1389
    • Cole-Strauss, A.1    Yoon, K.2    Xiang, Y.3
  • 12
    • 0032486203 scopus 로고    scopus 로고
    • Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors
    • Lan N, Howrey RP, Lee S-W, Smith CA, Sullenger BA. Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors. Science. 1998;280:1593-1596.
    • (1998) Science , vol.280 , pp. 1593-1596
    • Lan, N.1    Howrey, R.P.2    Lee, S.-W.3    Smith, C.A.4    Sullenger, B.A.5
  • 14
    • 0031897270 scopus 로고    scopus 로고
    • Human gene targeting by viral vectors
    • Russell DW, Hirata RK. Human gene targeting by viral vectors. Nat Genet. 1998;18:325-330,
    • (1998) Nat Genet , vol.18 , pp. 325-330
    • Russell, D.W.1    Hirata, R.K.2
  • 15
    • 0345711460 scopus 로고    scopus 로고
    • Gene targeting is enhanced in human cells overexpressing bRAD51
    • Yáñez RJ, Porter ACG, Gene targeting is enhanced in human cells overexpressing bRAD51, Gene Ther. 1999;6:1282-1290.
    • (1999) Gene Ther , vol.6 , pp. 1282-1290
    • Yáñez, R.J.1    Porter, A.C.G.2
  • 16
    • 0026704374 scopus 로고
    • Inactivation of the human β-globin gene by targeted insertion into the β-globin locus control region
    • Kim CG, Epner EM, Forrester WC, Groudine M. Inactivation of the human β-globin gene by targeted insertion into the β-globin locus control region. Genes Dev. 1992;6:928-938.
    • (1992) Genes Dev , vol.6 , pp. 928-938
    • Kim, C.G.1    Epner, E.M.2    Forrester, W.C.3    Groudine, M.4
  • 17
    • 0027305095 scopus 로고
    • An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: Analysis of the β-globin locus control region
    • Fiering S, Kim CG, Epner EM, Groudine M. An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the β-globin locus control region. Proc Natl Acad Sci U S A. 1993;90:8469-8473.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 8469-8473
    • Fiering, S.1    Kim, C.G.2    Epner, E.M.3    Groudine, M.4
  • 18
    • 0029091902 scopus 로고
    • Targeted deletion of 5′HS2 of the murine-β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus
    • Fiering S, Epner E, Robinson K, et al. Targeted deletion of 5′HS2 of the murine-β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus. Genes Dev. 1995;9:2203-2213.
    • (1995) Genes Dev , vol.9 , pp. 2203-2213
    • Fiering, S.1    Epner, E.2    Robinson, K.3
  • 19
    • 0029954767 scopus 로고    scopus 로고
    • Analysis of mice containing a targeted deletion of β-globin locus control region 5′ hypersensitive site 3
    • Hug BA, Wesselschmidt RL, Fiering S, et al. Analysis of mice containing a targeted deletion of β-globin locus control region 5′ hypersensitive site 3. Mol Cell Biol. 1996;16:2906-2912.
    • (1996) Mol Cell Biol , vol.16 , pp. 2906-2912
    • Hug, B.A.1    Wesselschmidt, R.L.2    Fiering, S.3
  • 20
    • 0029993449 scopus 로고    scopus 로고
    • Know your neighbors: Three phenotypes in null mutations of the myogenic bHLH gene MRF4
    • Olson EN, Arnold H-H, Rigby PWJ, Wold BJ. Know your neighbors: three phenotypes in null mutations of the myogenic bHLH gene MRF4. Cell. 1996;85:1-4.
    • (1996) Cell , vol.85 , pp. 1-4
    • Olson, E.N.1    Arnold, H.-H.2    Rigby, P.W.J.3    Wold, B.J.4
  • 22
    • 0030713405 scopus 로고    scopus 로고
    • Disruption of down-stream chromatin directed by a transcriptional activator
    • Brown SA, Kingston RE. Disruption of down-stream chromatin directed by a transcriptional activator. Genes Dev. 1997;11:3116-3121,
    • (1997) Genes Dev , vol.11 , pp. 3116-3121
    • Brown, S.A.1    Kingston, R.E.2
  • 23
    • 0030963918 scopus 로고    scopus 로고
    • A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1
    • McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997;94:6781-6785.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6781-6785
    • McDevitt, M.A.1    Shivdasani, R.A.2    Fujiwara, Y.3    Yang, H.4    Orkin, S.H.5
  • 24
    • 0031708415 scopus 로고    scopus 로고
    • The locus control region is necessary for gene expression in the human &-globin locus but not the maintenance of an open chromatin structure in erythroid cells
    • Reik A, Telling A, Zitnik G, Cimbora D, Epner E, Groudine M. The locus control region is necessary for gene expression in the human &-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol Cell Biol. 1998;18:5992-6000.
    • (1998) Mol Cell Biol , vol.18 , pp. 5992-6000
    • Reik, A.1    Telling, A.2    Zitnik, G.3    Cimbora, D.4    Epner, E.5    Groudine, M.6
  • 25
    • 0033231034 scopus 로고    scopus 로고
    • Transgenic analysis of a 100-kb human β-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome
    • Kaufman RM, Pham CTN, Ley TJ. Transgenic analysis of a 100-kb human β-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. Blood, 1999;94:3178-3184.
    • (1999) Blood , vol.94 , pp. 3178-3184
    • Kaufman, R.M.1    Pham, C.T.N.2    Ley, T.J.3
  • 26
  • 27
    • 0018842472 scopus 로고
    • Globin chain electrephoresis: A new approach to the determination of the Gg/Ag ratio in fetal haemoglobin and to studies of globin synthesis
    • Alter BP, Goff SC, Efremov GD, Gravely ME, Huisman THJ. Globin chain electrephoresis: a new approach to the determination of the Gg/Ag ratio in fetal haemoglobin and to studies of globin synthesis. Br J Haematol. 1980;44:527-534.
    • (1980) Br J Haematol , vol.44 , pp. 527-534
    • Alter, B.P.1    Goff, S.C.2    Efremov, G.D.3    Gravely, M.E.4    Huisman, T.H.J.5
  • 28
    • 0032904338 scopus 로고    scopus 로고
    • The 5'flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice
    • MacIvor DM, Pham CTN, Ley TJ. The 5'flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice. Blood. 1999;93:963-973.
    • (1999) Blood , vol.93 , pp. 963-973
    • MacIvor, D.M.1    Pham, C.T.N.2    Ley, T.J.3
  • 29
    • 0010637768 scopus 로고
    • Sickle hemoglobin
    • Williams WJ, Beutler E, Erslev AJ, Lichtman MA, eds. New York: McGraw-Hill
    • Kim HC, Schwartz E. Sickle hemoglobin. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA, eds. Hematology. 4th ed. New York: McGraw-Hill; 1990:1722-1723.
    • (1990) Hematology. 4th ed. , pp. 1722-1723
    • Kim, H.C.1    Schwartz, E.2
  • 30
    • 0032526640 scopus 로고    scopus 로고
    • Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene
    • Graubert TA, Hug BA, Wesselschmidt R, et al. Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene. Nucleic Acids Res. 1998;26:2849-2858.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2849-2858
    • Graubert, T.A.1    Hug, B.A.2    Wesselschmidt, R.3
  • 31
    • 0018117288 scopus 로고
    • Membrane-covered thin-layer optical cell for gas-reaction studies of hemoglobin
    • Dolman D, Gill SJ. Membrane-covered thin-layer optical cell for gas-reaction studies of hemoglobin. Anal Biochem. 1978;87:127-134.
    • (1978) Anal Biochem , vol.87 , pp. 127-134
    • Dolman, D.1    Gill, S.J.2
  • 32
    • 0026658695 scopus 로고
    • Regulation of oxygen affinity by quaternary enhancement: Does hemoglobin ypsilanti represent an allosteric intermediate?
    • Doyle ML, Lew G, Turner GJ, Rucknagel D, Ackers GK. Regulation of oxygen affinity by quaternary enhancement: does hemoglobin ypsilanti represent an allosteric intermediate? Proteins. 1992;14:351-362.
    • (1992) Proteins , vol.14 , pp. 351-362
    • Doyle, M.L.1    Lew, G.2    Turner, G.J.3    Rucknagel, D.4    Ackers, G.K.5
  • 33
    • 0020564074 scopus 로고
    • A mouse model for β-thalassemia
    • Skow LC, Burkhart B, Johnson FM, et al. A mouse model for β-thalassemia. Cell. 1983;34:1043-1052.
    • (1983) Cell , vol.34 , pp. 1043-1052
    • Skow, L.C.1    Burkhart, B.2    Johnson, F.M.3
  • 34
    • 0027417591 scopus 로고
    • Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene
    • Shehee WR, Oliver P, Smithies O. Lethal thalassemia after insertional disruption of the mouse major adult β-globin gene. Proc Natl Acad Sci U S A. 1993;90:3177-3181.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3177-3181
    • Shehee, W.R.1    Oliver, P.2    Smithies, O.3
  • 35
    • 0002964270 scopus 로고
    • Sickle hemoglobin polymer: Structure-function correlates
    • Embury SH, Hebbel RP, Mohandas N, Steinberg MH, eds. New York: Raven
    • Schechter AN, Noguchi CT. Sickle hemoglobin polymer: structure-function correlates. In: Embury SH, Hebbel RP, Mohandas N, Steinberg MH, eds, Sickle Cell Disease: Basic Principles and Clinical Practice. New York: Raven; 1994;33-51.
    • (1994) Sickle Cell Disease: Basic Principles and Clinical Practice , pp. 33-51
    • Schechter, A.N.1    Noguchi, C.T.2
  • 36
    • 0027050651 scopus 로고
    • High expression of human βS- and α-globins in transgenic mice: Hemoglobin composition and hematologic consequences
    • Fabry ME, Nagel RL, Pachnis A, Suzuka SM, Costantini F. High expression of human βS- and α-globins in transgenic mice: hemoglobin composition and hematologic consequences. Proc Natl Acad Sci U S A. 1992;89:12150-12154.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 12150-12154
    • Fabry, M.E.1    Nagel, R.L.2    Pachnis, A.3    Suzuka, S.M.4    Costantini, F.5
  • 37
    • 0027052258 scopus 로고
    • High expression of human βS- and α-globins in transgenic mice: Erythrocyte abnormalities, organ damage, and the effect of hypoxia
    • Fabry ME, Costantini F, Pachnis A, et al. High expression of human βS- and α-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Proc Natl Acad Sci U S A. 1992;89:12155-12159.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 12155-12159
    • Fabry, M.E.1    Costantini, F.2    Pachnis, A.3
  • 38
    • 0029831548 scopus 로고    scopus 로고
    • Magnetic resonance evidence of hypoxia in a homozygous a-knockout of a transgenic mouse model for sickle cell disease
    • Fabry ME, Kennan RP, Pàszty C, et al. Magnetic resonance evidence of hypoxia in a homozygous a-knockout of a transgenic mouse model for sickle cell disease. J Clin Invest. 1996;98:2450-2455.
    • (1996) J Clin Invest , vol.98 , pp. 2450-2455
    • Fabry, M.E.1    Kennan, R.P.2    Pàszty, C.3
  • 39
    • 0030725279 scopus 로고    scopus 로고
    • Knockouttransgenic mouse model of sickle cell disease
    • Ryan TM, Ciavatta DJ, Townes TM. Knockouttransgenic mouse model of sickle cell disease. Science. 1997;278:873-875.
    • (1997) Science , vol.278 , pp. 873-875
    • Ryan, T.M.1    Ciavatta, D.J.2    Townes, T.M.3
  • 40
    • 1842408336 scopus 로고    scopus 로고
    • Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease
    • Pàszty C, Brion CM, Manci E, et al. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science. 1997;278:876-878.
    • (1997) Science , vol.278 , pp. 876-878
    • Pàszty, C.1    Brion, C.M.2    Manci, E.3
  • 41
    • 6044237092 scopus 로고    scopus 로고
    • Transgenic knock-out mice exclusively expressing human hemoglobin S after transfer of a 240-kb βS-globin yeast artificial chromosome: A mouse model of sickle cell anemia
    • Chang JC, Lu R, Lin C, et al. Transgenic knock-out mice exclusively expressing human hemoglobin S after transfer of a 240-kb βS-globin yeast artificial chromosome: a mouse model of sickle cell anemia. Proc Natl Acad Sci U S A. 1998;95:14886-14890.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14886-14890
    • Chang, J.C.1    Lu, R.2    Lin, C.3


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