The renin-angiotensin system in the brain: An update

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 2, Issue 2, 2001, Pages 96-102

  Culman, Juraj ^a   Baulmann, Johannes ^b   Blume, Annegret ^a   Unger, Thomas ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Angiotensin; Apoptosis; AT1 receptor; AT2 receptor; Cell growth; Central nervous system; Differentiation; Regeneration; Renin angiotensin system; Stroke; Tissue

Indexed keywords

BRAIN; HUMAN; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

BRAIN; HUMANS; RENIN-ANGIOTENSIN SYSTEM;

EID: 0035382991     PISSN: 14703203     EISSN: None     Source Type: Journal    
DOI: 10.3317/jraas.2001.019     Document Type: Review

References (70)

1. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger Th. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52(3):415-72.
2. Höhle S, Blume A, Lebrun C, Culman J, Unger T. Angiotensin receptors in the brain. Pharmacol Toxicol 1995;77(5):306-15.
3. McKinley MJ, McAllen RM, Mendelsohn FAO, Allen AM, Chai SY, Oldfield BJ. Circumventricular organs: Neuroendocrine interfaces between the brain and hemal millieu. Front Neuroendocrinol 1990;11:91-127.
4. Muratami H, Teruya H, Sesoko S, Takishita S, Fukiyama K. Brain angiotensin and circulatory control. Clin Exp Pharmacol Physiol 1996;23:458-64.
5. Fitzsimons JT. Angiotensin, thirst, and sodium appetite. Physiol Rev 1998;78:583-686.
6. Davisson RL, Oliviero MI, Coffman TM, Sigmund CD. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 2000;106:103-6.
7. Veltmar A, Culman J, Qadri F, Rascher W, Unger T. Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin H-induced vasopressin release. J Pharmacol Exp Ther 1992;263(3):1253-60.
8. Culman J, Hohle S, Qadri F, Edling O, Blume A, Lebrun C, Unger Th. Angiotensin as neuromodulator/neurotransmitter in central control of body fluid and electrolyte homeostasis. Clin Exp Hypertens 1995;17(1-2):281-93.
9. Lenkei Z, Corvol P, Llorens-Cortes C. Comparative expression of vasopressin and angiotensin type-1 receptor mRNA in rat hypothalamic nuclei: a double in situ hybridization study. Mol Brain Res 1995;34:135-42.
10. Saavedra JM. Brain and pituitary angiotensin. Endocr Rev 1992;13(2):329-80.
11. Phillips MI. Antisense inhibition and adeno-associated viral vector delivery for reducing hypertension. Hypertension 1997;29:177-87.
12. Nakamura S, Moriguchi A, Morishita R et al. Activation of brain angiotensin system by in vivo human angiotensin-converting enzyme gene transfer in rats. Hypertension 1999;34:302-8.
13. Paton JRF, Kasparov S. Sensory channel specific modulation in the nucleus of the solitary tract. J Autonom Nerv Syst 2000;80:117-29.
14. Unger Th. The angiotensin type 2 receptor: variations on an enigmatic theme. J Hypertens 1999;17:1775-86.
15. Lucius R, Gallinat S, Busche S, Rosenstiel P, Unger Th. Beyond blood pressure: new roles for angiotensin II. Cell Mol Life Sci 1999;56:1008-19.
16. 1 receptors in rat median eminence increases phosphoinositide hydrolysis. Brain Res 1995;705(1-2):24-30.
17. Yang H, Lu D, Yu K, Raizada MK. Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway. J Neurosci 1996;16(13):4047-58.
18. Lu D, Yang H, Raizada MK. Angiotensin II regulation of neuromodulation: Downstream signaling mechanism from activation of mitogen-activated protein kinase. J Cell Biol 1996; 135:1609-17.
19. 1 receptors. J Neurosci 1997; 17:1660-9.
20. Huang XC, Richards EM, Sumners C. Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors. J Biol Chem 1996;271(26):15635-41.
21. Yu K, Lu D, Rowland NE, Raizada MK. Angiotensin II regulation of tyrosine hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats. Endocrinology 1996;137(8):3566-76.
22. Yang H, Raizada MK. MAP kinase-independent signaling in angiotensin II regulation of neuromodulation in SHR neurons. Hypertension 1998;32:473-81.
23. Zhu M, Neubig RR, Wade SM, Posner P, Gelband CH, Sumners C. Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide. Am J Physiol 1997;273:C1040-C1048.
24. Zhu M, Gelband CH, Posner P, Sumners C. Angiotensin II type 1 receptor-mediated inhibition of voltage-dependent K+ current in cultured neurons: role of calcium/calmodulin-dependent protein kinase. FASEB J 1998;12:A54.
25. Yang CR, Phillips MI, Renaud LP. Angiotensin II receptor activation depolarizes rat supraoptic neurons in vitro. Am J Physiol 1992;321:R1333-R1338.
26. 2-terminal kinase in neuronal cultures from rat brain. Endocrinology 1998;139(1):245-51.
27. Yang CR, Raizada MK. Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat. J Neurosci 1999;19:2413-23.
28. Herbert J, Forsling ML, Howes SR, Stacey PM, Shiers HM. Regional expression of c-fos antigen in the basal forebrain following intraventricular infusion of angiotensin and its modulation by drinking either water or saline. Neuroscience 1992;51:867-82.
29. Blume A, Herdegen T, Unger Th. Angiotensin peptides and inducible transcription factors. J Mol Med 1999;77:339-57.
30. 1 receptors. Brain Res 1995;675:127-34.
31. Blume A, Lebrun CJ, HerdegenT et al. Increased brain transcription factor expression in genetic hypertension. Hypertension 1997;29:592-8.
32. 2 receptor. Trends Endocrinol Metab 2000; 11:1-6.
33. 2 receptor stimulates ERK1 and ERK2 in quiescent but inhibits ERK in NGF-stimulated PC12W cells. Brain Res Mol Brain Res 2000;78:175-80.
34. Dimmeler S, Rippmann V, Weiland U, Haendeler J, Zeiher AM. Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide. Circ Res 1997;81:970-6.
35. 2 receptor stimulation induces generation of ceramides in PC 12W cells. FEBS Lett 1999;433:75-9.
36. 2 receptor-induced apoptosis. J Biol Chem 1999;274:16901-6.
37. Miura S, Karnik SS. Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis. EMBO J 2000; 19:4026-35.
38. 2) in rat brain. Am J Physiol 1991;261:667-70.
39. 2 receptors in the developing rat fetus. J Clin Invest 1991;88(3):921-33.
40. Unger Th, Chung O, Csikos T et al. Angiotensin receptors. J Hypertens 1996;14(5)(Suppl):S95-S103.
41. Sayeski PP, Ali MS, Semeniuk DJ, Doan TN, Bernstein KE. Angiotensin II signal transduction pathways. Regul Pept 1998;78:19-29.
42. 2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996;122(1):59-67.
43. 1 receptors. J Biol Chem 1996;271(37):22729-35.
44. Mesner PW, Epting CL, Hegarty JL, Green SH. A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells. J Neurosci 1995; 15:7357-66.
45. 2 receptor. Mol Brain Res 1998;53(1-2):187-95.
46. 2 receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum. J Biol Chem 1999;274:31686-92.
47. Herdegen T, Skene P, Bähr M. The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 1997;20:227-31.
48. Kinloch RA, Treherne JM, Furness LM, Hajimohamadreza I. The pharmacology of apoptosis. TIPS 1999;20:35-42.
49. Yamada T, Horiuchi M, Dzau VJ. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996;93(1):156-60.
50. Horiuchi M, Yamada T, Hayashida W, Kambe T, Yamada T, Dzau VJ. Angiotensin type2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 1997;272:19022-6.
51. Horiuchi M, Akishita M, Dzau M. Molecular and cellular mechanism of angiotensin II-mediated apoptosis. Endocr Res 1998;24:307-14.
52. 2 receptor down-regulates neurofilament M in PC12W cells. Neurosci Lett 1997;227(1):29-32.
53. Hofmann K, Dixit VM. Ceramide in apoptosis - does it really matter? TIBS 1998;23:374-7.
54. 2) receptor promotes axonal regeneration in the optic nerve of adult rats. J Exp Med 1998;188:661-70.
55. 1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves. Mol Brain Res 1998;57(1):111-22.
56. Choi DW. Ischemia-induced neural apoptosis. Curr Opinion Neurobiol 1996;6:667-72.
57. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. TINS 1999;22:391-7.
58. von Lutterotti N, Camargo MJ, Campbell WG Jr, Mueller FB, Timmermans PB, Sealey JE, Laragh JH. Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats. J Hypertens 1992;10:949-57.
59. Stier CT Jr, Adler LA, Levien S, Chandler PN. Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats. J Hypertens 1993;11(3)(Suppl):S37-42.
60. Werner C, Hoffman WE, Kochs E, Rabito SF, Miletich DJ. Captopril improves neurologic outcome from incomplete cerebral ischemia in rats. Stroke 1991;22:910-4.
61. Sadoshima S, Fujii K, Ooboshi H, Ibayashi S, Fujishima M. Angiotensin converting enzyme inhibitors attenuate ischemic brain metabolism in hypertensive rats. Stroke 1993;24:1561-7.
62. Paulson OB, Waldemar G, Andersen AR et al. Role of angiotensin in autoregulation of cerebral blood flow. Circulation 1988;77(Suppl I):I-55-58.
63. Inada Y, Wada T, Ojima M et al. Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens 1997;19:1079-99.
64. 1 blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats. Stroke 2000;31:2478-86.
65. 1 receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats. Stroke 1999;30:2391-9.
66. 2 receptor mRNA level after global ischemia in the rat. Neuropeptides 1996;30:596-601.
67. 1 receptor antagonists to cross the blood-brain in rats. Eur J Pharmacol 1996;307:259-67.
68. Culman J, von Heyer C, Piepenburg B, Rascher W, Unger T. Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats. Eur J Pharmacol 1999;367:255-65.
69. 1 receptors. Brain Res 2000;871:29-38.
70. 1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats. J Pharmacol Exp Ther 2001 (in print).