Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats

European Journal of Pharmacology

Volumn 367, Issue 2-3, 1999, Pages 255-265

  Culman, Juraj ^a,b   Von Heyer, Christian ^a   Piepenburg, Britta ^a   Rascher, Wolfgang ^c   Unger, Thomas ^a,b  

^a UNIVERSITY OF KIEL   (Germany)

^b German Institute for High Blood Pressure Research   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Angiotensin AT1 receptor; Angiotensin II; Brain; Drinking behaviour; Irbesartan; Losartan; Pressor response; Rat; Vasopressin release

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR; IRBESARTAN; LOSARTAN; VASOPRESSIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FLUID INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; VASOPRESSIN BLOOD LEVEL; VASOPRESSIN RELEASE;

ADMINISTRATION, ORAL; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; DRUG INTERACTIONS; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; LOSARTAN; MALE; PITUITARY GLAND, POSTERIOR; RATS; RATS, WISTAR; RECEPTORS, ANGIOTENSIN; TETRAZOLES; VASOPRESSINS;

EID: 0033010019     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00983-2     Document Type: Article

References (47)

1. Bui J.D., Kimura B., Phillips M.I. Losartan potassium, a non-peptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood-brain barrier. Eur. J. Pharmacol. 219:1992;147-151.
2. 1-receptor antagonists in spontaneously hypertensive rats. Br. J. Pharmacol. 116:1995;3181-3190.
3. 1 subtype angiotensin II receptor antagonist. J. Pharmacol. Exp. Ther. 265:1993;826-834.
4. Csajka C., Buclin T., Brunner H.R., Biollaz J. Pharmacokinetic-pharmacodynamic profile of angiotensin II receptor antagonists. Clin. Pharmacokinet. 32:1997;1-29.
5. Culman J., Ritter S., Ohlendorf C., Haass M., Maser-Gluth C., Spitznagel H., Unger Th. A new formalin test allowing simultaneous evaluation of cardiovascular and nociceptive responses. Can. J. Physiol. Pharmacol. 75:1997;1203-1211.
6. DePasquale M.J., Fossa A.A., Holt W.F., Mangiapane M.L. Central DuP 753 does not lower blood pressure in spontaneously hypertensive rats. Hypertension. 19:1992;668-671.
7. Fitts D.A. Angiotensin II receptors in SFO but not in OVLT mediate isoproterenol-induced thirst. Am. J. Physiol. 267:1994;R7-R15.
8. Gardiner T.W., Stricker E.M. Impaired drinking responses of rats with lesions of nucleus medianus: circadian dependence. Am. J. Physiol. 248:1985;R224-R230.
9. Gillis J.C., Markham A. Irbesartan. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension. Drugs. 54:1997;885-902.
10. Griendling K.K., Lassègue B., Alexander R.W. Angiotensin receptors and their therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 36:1996;281-306.
11. Gutkind J.S., Kurihara M., Castren E., Saavedra J.M. Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. J. Hypertens. 6:1988;79-84.
12. 1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Regul. Pept. 49:1993;167-174.
13. 1 receptors in the central control of sympathetic vasomotor function. Clin. Exp. Pharmacol. Physiol. 3:1996;S93-S98. Suppl.
14. 2 receptors in the pressor, drinking and vasopressin responses to central angiotensin. Brain Res. 586:1992;289-294.
15. Höhle S., Blume A., Lebrun C., Culman J., Unger Th. Angiotensin receptors in the brain. Pharmacol. Toxicol. 77:1995;306-315.
16. Johnson, A.K., Edwards, G.J., 1990. The neuroendocrinology of thirst: afferent signaling and mechanisms of central integration. In: Ganten, D., Pfaff, D. (Eds.), Current Topics in Neuroendocrinology, Vol. 10. Springer, Berlin, pp. 149-190.
17. Lenkei Z., Palkovits M., Corvol P., Llorens-Cortes C. Distribution of angiotensin type-1 receptor messenger RNA expression in the adult rat brain. Neuroscience. 82:1998;827-841.
18. Li Z., Bains J.S., Fergusson A.V. Functional evidence that the angiotensin antagonist losartan crosses the blood-brain barrier in the rat. Brain Res. Bull. 30:1993;33-39.
19. Lind R.W., Swanson L.W., Ganten D. Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. Neuroendocrinology. 40:1985;2-24.
20. Ludbrook J. On making multiple comparisons in clinical and experimental pharmacology and physiology. Clin. Exp. Pharmacol. Physiol. 18:1991;379-392.
21. Ludbrook J. Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc. Res. 28:1994;303-311.
22. Mangiapane M.L., Thrasher T.N., Keil L.C., Simpson J.B., Ganong W.F. Deficits in drinking and vasopressin secretion after lesions of the nucleus medianus. Neuroendocrinology. 37:1983;73-77.
23. McKinley M.J., McAllen R.M., Mendelsohn F.A.O., Allen A.M., Chai S.Y., Oldfield B.J. Circumventricular organs: neuroendocrine interfaces between the brain and the hemal milieu. Frontiers in Neuroendocrinology. 11:1990;91-127.
24. Obermüller N., Unger Th., Culman J., Gohlke P., de Gasparo M., Bottari S.P. Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neurosci. Lett. 132:1991;11-15.
25. Oldfield B.J., Hards D.K., McKinley M.J. Projections from the subfornical organ to the supraoptic nucleus in the rat: ultrastructural identification of an interposed synapse in the median preoptic nucleus using a combination of neuronal tracers. Brain Res. 558:1991;13-19.
26. Phillips M.I., Kimura B. Brain angiotensin in the developing spontaneously hypertensive rats. J. Hypertens. 6:1988;607-612.
27. Plunkett L.M., Saavedra J.M. Increased angiotensin II binding affinity in the nucleus tractus solitarius of spontaneously hypertensive rats. Proc. Natl. Acad. Sci. 82:1985;7721-7724.
28. 1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of angiotensin II in rats. Eur. J. Pharmacol. 277:1995;223-228.
29. 1 receptor antagonists to cross the blood-brain barrier in rats. Eur. J. Pharmacol. 307:1996;259-267.
30. Polidori C., Ciccocioppo R., Nisato D., Cazaubon C., Massi M. Evaluation of the ability of irbesartan to cross the blood-brain barrier following acute intragastric treatment. Eur. J. Pharmacol. 352:1998;15-21.
31. 1 receptors in the supraoptic nucleus. J. Pharmacol. Exp. Ther. 267:1993;567-574.
32. Rascher W., Weidmann E., Gross F. Vasopressin in the plasma of stroke-prone spontaneously hypertensive rats. Clin. Sci. 61:1981;295-298.
33. Saavedra J.M. Brain and pituitary angiotensin. Endocr. Rev. 13:1992;329-380.
34. Song K., Zhuo J., Mendelsohn F.A.O. Access of peripherally administered DuP 753 to rat brain angiotensin receptors. Br. J. Pharmacol. 104:1991;771-772.
35. Song K., Allen A.M., Paxinos G., Mendelsohn F.A.O. Mapping of angiotensin II receptor subtype heterogeneity in rat brain. J. Comp. Neurol. 316:1992;467-484.
36. Steckelings U., Lebrun C., Qadri F., Veltmar A., Unger Th. Role of brain angiotensin in cardiovascular regulation. J. Cardiovasc. Pharmacol. 19(6):1992;S72-S79. Suppl.
37. Terrel M.L., Kaderako M., Freeman S., Eisenberg H. Effects of chemical stimulation of the subfornical organ on metabolic activity of the hypothalamo-neurohypohyseal system in rats. Neurosci. Lett. 134:1991;122-126.
38. Timmermans P.B.M.W.M., Wong P.C., Chiu A.T., Herblin W.F., Benfield P., Carini D.J., Lee R.J., Wexler R.R., Saye J.A.M., Smith R.D. Angiotensin II receptors and angiotensin receptor antagonists. Pharmacol. Rev. 45:1993;205-251.
39. Unger Th., Becker H., Petty M., Demmert G., Schneider B., Ganten D., Lang R.E. Differential effects of central angiotensin II and substance P on sympathetic nerve activity in conscious rats. Circ. Res. 56:1985;563-575.
40. Unger Th., Badoer E., Ganten D., Lang R.E., Rettig R. Brain angiotensin: pathways and pharmacology. Circulation. 77(1):1988;I40-I54. Suppl.
41. Unger Th., Chung O., Csikós T., Culman J., Gallinat S., Gohlke P., Höhle S., Meffert S., Stoll M., Stroth U., Zhu Y.-Z. Angiotensin receptors. Hypertension. 14(5):1996;S95-S103. Suppl.
42. 1 receptor antagonist irbesartan in hypertension. Hypertension. 25:1995;22-29.
43. Veltmar A., Culman J., Qadri F., Rascher W., Unger Th. Involvement of adrenergic and angiotensinergic receptors in the paraventricular nucleus in the angiotensin II-induced vasopressin release. J. Pharmacol. Exp. Ther. 263:1992;1253-1260.
44. Wong P.C., Price W.A., Chiu A.T., Duncia J.V., Carini D.J., Wexler R.R., Johnson A.L., Timmermans P.B.M.W.M. Non-peptide angiotensin II receptor antagonists: VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 252:1990;719-725.
45. Wong P.C., Price W.A., Chiu A.T., Duncia J.V., Carini D.J., Wexler R.R., Johnson A.L., Timmermans P.B.M.W.M. Non-peptide angiotensin II receptor antagonists: IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent. Pharmacol. Exp. Ther. 252:1990;726-732.
46. Wong P.C., Price W.A. Jr., Chiu A.T., Duncia J.V., Carini D.J., Wexler R.R., Johnson A.L., Timmermans P.B.M.W.M. Non-peptide angiotensin II receptor antagonists: XI. Pharmacology of EXP3174: an active metabolite of DuP 753 an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 255:1990;211-217.
47. 1 angiotensin II receptors in rat brain, kidney and adrenals demonstrated by in vitro autoradiography. Clin. Exp. Pharmacol. Physiol. 21:1994;557-567.