메뉴 건너뛰기




Volumn 19, Issue 7, 1997, Pages 1079-1099

Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats

Author keywords

Candesartan cilexetil; Enalapril; Organ damages; Renal mRNA; Renin angiotensin system; Stroke prone spontaneously hypertensive rats(SHRSP); TCV 116

Indexed keywords

CANDESARTAN HEXETIL; ENALAPRIL;

EID: 0030800377     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969709083206     Document Type: Article
Times cited : (108)

References (54)
  • 1
    • 0014200585 scopus 로고
    • Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressure averaging 115 through 129 mmHg
    • Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressure averaging 115 through 129 mmHg. JAMA. 1967; 202: 1028-1034.
    • (1967) JAMA , vol.202 , pp. 1028-1034
  • 2
    • 0014952910 scopus 로고
    • Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mmHg
    • Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mmHg. JAMA. 1970; 213: 1143-1152.
    • (1970) JAMA , vol.213 , pp. 1143-1152
  • 4
    • 0021863832 scopus 로고
    • MRC trial of treatment of mild hypertension: Principal results
    • Medical Research Council Working Party: MRC trial of treatment of mild hypertension: principal results. Br Med J. 1985; 291: 97-104.
    • (1985) Br Med J , vol.291 , pp. 97-104
  • 5
    • 0022254994 scopus 로고
    • Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker oxprenolol: The International Prospective Primary Prevention Study in Hypertension (IPPPSH)
    • The IPPPSH Collaborative Group: Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker oxprenolol: the International Prospective Primary Prevention Study in Hypertension (IPPPSH). J Hypertens. 1985; 3: 379-392.
    • (1985) J Hypertens , vol.3 , pp. 379-392
  • 6
    • 0016222572 scopus 로고
    • Establishment of the stroke-prone spontaneously hypertensive rat (SHR)
    • Okamoto, K., Yamori, Y., Nagaoka, A.: Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res. 1974; 34/35 (suppl 1):1-143-1-145.
    • (1974) Circ Res , vol.34-35 , Issue.1 SUPPL. , pp. 1143-1145
    • Okamoto, K.1    Yamori, Y.2    Nagaoka, A.3
  • 7
    • 0017264890 scopus 로고
    • Pathogenic similarity of stroke in stroke-prone SHR and humans
    • Yamori, Y., Horie, R., Sato, M., Handa, H., Fukasa, M.: Pathogenic similarity of stroke in stroke-prone SHR and humans. Stroke. 1976; 7: 46-53.
    • (1976) Stroke , vol.7 , pp. 46-53
    • Yamori, Y.1    Horie, R.2    Sato, M.3    Handa, H.4    Fukasa, M.5
  • 8
    • 8244264903 scopus 로고
    • Renin-angiotensin system in stroke-prone spontaneously hypertensive rats
    • Shibota, M., Nagaoka, A., Shino, A., Fujita, T.: Renin-angiotensin system in stroke-prone spontaneously hypertensive rats. Am J Physiol. 1979; 236: H409-H416.
    • (1979) Am J Physiol , vol.236
    • Shibota, M.1    Nagaoka, A.2    Shino, A.3    Fujita, T.4
  • 9
    • 0024538697 scopus 로고
    • Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats
    • Stier, C.T, Jr, Benter, I.F., Ahmad, S., Zuo, H., Selig, N., Roethel, S., Levine, S., Itskovitz, H.D.: Enalapril prevents stroke and kidney dysfunction in salt-loaded stroke-prone spontaneously hypertensive rats. Hypertension. 1989; 13: 115-121.
    • (1989) Hypertension , vol.13 , pp. 115-121
    • Stier Jr., C.T.1    Benter, I.F.2    Ahmad, S.3    Zuo, H.4    Selig, N.5    Roethel, S.6    Levine, S.7    Itskovitz, H.D.8
  • 10
    • 0021804494 scopus 로고
    • Chronic effects of enalapril on blood pressure, stroke, plasma renin, urinary electrolytes and PGE2 excretion in stroke-prone spontaneously hypertensive rats
    • Watanabe, T., Kawashima, K., Sokabe, H.: Chronic effects of enalapril on blood pressure, stroke, plasma renin, urinary electrolytes and PGE2 excretion in stroke-prone spontaneously hypertensive rats. Jpn J Pharmacol. 1985; 38: 419-427.
    • (1985) Jpn J Pharmacol , vol.38 , pp. 419-427
    • Watanabe, T.1    Kawashima, K.2    Sokabe, H.3
  • 11
    • 9844239255 scopus 로고
    • Beneficial effects of cicletanide in stroke-prone hypertensive rats
    • Baranes, J., Hegarat, L.M.E., Thievant, P., Siou, G.: Beneficial effects of cicletanide in stroke-prone hypertensive rats. (abstract) Prostaglandins. 1984; 27(suppl): s71.
    • (1984) Prostaglandins , vol.27 , Issue.SUPPL.
    • Baranes, J.1    Hegarat, L.M.E.2    Thievant, P.3    Siou, G.4
  • 12
    • 0025034427 scopus 로고
    • Delapril prevents stroke, renal dysfunction and cardiac hypertrophy in stroke prone spontaneously hypertensive rats
    • Inada, Y., Itoh, K., Ojima, M., Shino, A., Nishikawa, K.: Delapril prevents stroke, renal dysfunction and cardiac hypertrophy in stroke prone spontaneously hypertensive rats. Jpn Pharmacol Ther. 1990; 18: 2199-2209.
    • (1990) Jpn Pharmacol Ther , vol.18 , pp. 2199-2209
    • Inada, Y.1    Itoh, K.2    Ojima, M.3    Shino, A.4    Nishikawa, K.5
  • 13
    • 0026099204 scopus 로고
    • Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats
    • Hajdu, M.A., Heistad, D.D., Baumbach, G.L.: Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats. Hypertension. 1991; 17: 308-316.
    • (1991) Hypertension , vol.17 , pp. 308-316
    • Hajdu, M.A.1    Heistad, D.D.2    Baumbach, G.L.3
  • 14
    • 0027509549 scopus 로고
    • Prophylactic effect of imidapril of stroke in stroke-prone spontaneously hypertensive rats
    • Ogiku, N., Sumikawa, H., Hashimoto, Y., Ishida, R., : Prophylactic effect of imidapril of stroke in stroke-prone spontaneously hypertensive rats. Stroke. 1993, 24;245-252.
    • (1993) Stroke , vol.24 , pp. 245-252
    • Ogiku, N.1    Sumikawa, H.2    Hashimoto, Y.3    Ishida, R.4
  • 15
    • 9844253785 scopus 로고
    • Renal and vascular lesions in rats with deoxycorticosterone hypertension
    • Masson, G.M.C., Corcoran, A.C., Page, I.H.: Renal and vascular lesions in rats with deoxycorticosterone hypertension. Arch Pathol. 1952; 53:217-225.
    • (1952) Arch Pathol , vol.53 , pp. 217-225
    • Masson, G.M.C.1    Corcoran, A.C.2    Page, I.H.3
  • 16
    • 0005733982 scopus 로고
    • Experimental vascular disease caused by aldosterone and renin
    • Masson, G.M.C., Mikasa, A., Yasuda, H.: Experimental vascular disease caused by aldosterone and renin. Endocrinology. 1962. 71: 505-512.
    • (1962) Endocrinology , vol.71 , pp. 505-512
    • Masson, G.M.C.1    Mikasa, A.2    Yasuda, H.3
  • 17
    • 0000871114 scopus 로고
    • Hypertensive vascular disease produced by homologous renin
    • Masson, G.M.C., Kashii, C., Matsunaga, M., Page, I.H.: Hypertensive vascular disease produced by homologous renin. Science. 1964; 145: 178-180.
    • (1964) Science , vol.145 , pp. 178-180
    • Masson, G.M.C.1    Kashii, C.2    Matsunaga, M.3    Page, I.H.4
  • 18
    • 0015209239 scopus 로고
    • Acute renal failure, tubular necrosis and myocardial infarction induced in the rabbit by intravenous angiotensin II
    • Gavras, H., Lever, A.F., Brown, J.J., Macadam, R.F., Robertson, I.J.: Acute renal failure, tubular necrosis and myocardial infarction induced in the rabbit by intravenous angiotensin II. Lancet. 1971; ii: 19-22.
    • (1971) Lancet , vol.2 , pp. 19-22
    • Gavras, H.1    Lever, A.F.2    Brown, J.J.3    Macadam, R.F.4    Robertson, I.J.5
  • 20
    • 0015333482 scopus 로고
    • Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease
    • Laragh, J.H., Baer, L., Brunner, H.R., Buhler, F.R., Sealey, J.E., Vaughan, E.D. Jr.: Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med. 1972; 52: 633-652.
    • (1972) Am J Med , vol.52 , pp. 633-652
    • Laragh, J.H.1    Baer, L.2    Brunner, H.R.3    Buhler, F.R.4    Sealey, J.E.5    Vaughan Jr., E.D.6
  • 22
    • 0025794059 scopus 로고
    • Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
    • Alderman, M.H., Madhavan, S., Ooi, W.L., Cohen, H., Sealey, J.E., Laragh, J.H.: Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. N Engl J Med. 1991; 324: 1098-1104.
    • (1991) N Engl J Med , vol.324 , pp. 1098-1104
    • Alderman, M.H.1    Madhavan, S.2    Ooi, W.L.3    Cohen, H.4    Sealey, J.E.5    Laragh, J.H.6
  • 23
    • 0027327826 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids
    • Kubo, K., Kohara, Y., Yoshimura, Y., Inada, Y., Shibouta, Y., Furukawa, Y., Kato, T., Nishikawa, K., Naka, T.: Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids. J. Med. Chem. 1993; 36: 2343-2349.
    • (1993) J. Med. Chem. , vol.36 , pp. 2343-2349
    • Kubo, K.1    Kohara, Y.2    Yoshimura, Y.3    Inada, Y.4    Shibouta, Y.5    Furukawa, Y.6    Kato, T.7    Nishikawa, K.8    Naka, T.9
  • 24
    • 0027431141 scopus 로고
    • Pharmacological profile of a highly potent and long-acting angiotensin H receptor antagonist, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl]-1 H-benzimidazole-7-carboxylic acid (CV-11974) and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′- (1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116)
    • Shibouta, Y., Inada, Y., Ojima, M., Wada, T., Noda, M., Sanada, T., Kubo, K., Kohara, Y., Naka, T., Nishikawa, K.: Pharmacological profile of a highly potent and long-acting angiotensin H receptor antagonist, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1 H-benzimidazole-7-carboxylic acid (CV-11974) and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole- 7-carboxylate (TCV-116). J Pharmacol Exp Ther. 1993; 266: 114-120.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 114-120
    • Shibouta, Y.1    Inada, Y.2    Ojima, M.3    Wada, T.4    Noda, M.5    Sanada, T.6    Kubo, K.7    Kohara, Y.8    Naka, T.9    Nishikawa, K.10
  • 26
    • 0028194874 scopus 로고
    • Antihypertensive effects of a highly potent and long acting angiotensin II subtype-1 receptor antagonist, (±) - 1 -(cyclohexyloxycarbonyloxy) ethyl 2 - ethoxy -1 - [[2′- (1 H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats
    • Inada, Y., Wada, T., Shibouta, Y., Ojima, M., Sanada, T., Ohtsuki, K., Itoh, K., Kubo, K., Kohara, Y., Naka, T., Nishikawa, K.: Antihypertensive effects of a highly potent and long acting angiotensin II subtype-1 receptor antagonist, (±) - 1 -(cyclohexyloxycarbonyloxy) ethyl 2 - ethoxy -1 - [[2′- (1 H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116), in various hypertensive rats. J Pharmacol Exp Ther. 1994; 268: 1540-1547.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1540-1547
    • Inada, Y.1    Wada, T.2    Shibouta, Y.3    Ojima, M.4    Sanada, T.5    Ohtsuki, K.6    Itoh, K.7    Kubo, K.8    Kohara, Y.9    Naka, T.10    Nishikawa, K.11
  • 27
    • 0028903406 scopus 로고
    • Effects of the non-peptide angiotensin II receptor antagonist TCV-116 on systemic and renal hemodynamics in dogs with renal hypertension
    • Ito, K., Shiomi, M., Kito, G.: Effects of the non-peptide angiotensin II receptor antagonist TCV-116 on systemic and renal hemodynamics in dogs with renal hypertension. Hypertens Res. 1995; 18: 69-75.
    • (1995) Hypertens Res , vol.18 , pp. 69-75
    • Ito, K.1    Shiomi, M.2    Kito, G.3
  • 28
    • 0028956159 scopus 로고
    • Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats
    • Wada, T., Kanagawa, R., Ishimura, Y., Inada, Y., Nishikawa, K.: Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats. J Hypertens. 1995; 13: 113-122.
    • (1995) J Hypertens , vol.13 , pp. 113-122
    • Wada, T.1    Kanagawa, R.2    Ishimura, Y.3    Inada, Y.4    Nishikawa, K.5
  • 29
    • 0019226195 scopus 로고
    • Acceleration of hypertension and development of stroke in the spontaneously hypertensive rat by unilateral ureteral obstruction
    • Inada, Y., Terashita, Z., Shibouta, Y., Nishikawa, K., Shino, A., Kikuchi, S., Shimamoto, K.: Acceleration of hypertension and development of stroke in the spontaneously hypertensive rat by unilateral ureteral obstruction. Clin Exp Hypertens. 1980; 2: 139-152.
    • (1980) Clin Exp Hypertens , vol.2 , pp. 139-152
    • Inada, Y.1    Terashita, Z.2    Shibouta, Y.3    Nishikawa, K.4    Shino, A.5    Kikuchi, S.6    Shimamoto, K.7
  • 30
    • 0026671341 scopus 로고
    • Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method
    • Iwai, N., Inagami, T.: Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method. J Hypertens. 1992; 10: 717-724.
    • (1992) J Hypertens , vol.10 , pp. 717-724
    • Iwai, N.1    Inagami, T.2
  • 31
    • 0026794976 scopus 로고
    • Intracardiac detection of angiotensinogen and renin: A localized renin-angiotensin system in neonatal rat heart
    • Dostal, D.E., Rothblum, K.N., Chemin, M.I., Cooper, G.R., Baker, K.M.: Intracardiac detection of angiotensinogen and renin: a localized renin-angiotensin system in neonatal rat heart. Am J Physiol. 1992; 263: C838-C850.
    • (1992) Am J Physiol , vol.263
    • Dostal, D.E.1    Rothblum, K.N.2    Chemin, M.I.3    Cooper, G.R.4    Baker, K.M.5
  • 32
    • 0026653005 scopus 로고
    • Two distinct pathways in the down-regulation of type-1 angiotensin II receptor gene in rat glomerular mesangial cells
    • Makita, N., Iwai, N., Inagami, T., Badr, K.F.: Two distinct pathways in the down-regulation of type-1 angiotensin II receptor gene in rat glomerular mesangial cells. Biochem Biophys Res Commun. 1992; 185: 142-146.
    • (1992) Biochem Biophys Res Commun , vol.185 , pp. 142-146
    • Makita, N.1    Iwai, N.2    Inagami, T.3    Badr, K.F.4
  • 33
    • 0026441234 scopus 로고
    • Differential gene expression and regulation of type-1 angiotensin II receptor subtype in the rat
    • Kitami, Y., Okura, T., Marumoto, K., Wakamiya, R., Hiwada, K.: Differential gene expression and regulation of type-1 angiotensin II receptor subtype in the rat. Biochem Biophys Res Commun. 1992; 188: 446-452.
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 446-452
    • Kitami, Y.1    Okura, T.2    Marumoto, K.3    Wakamiya, R.4    Hiwada, K.5
  • 34
    • 0017118963 scopus 로고
    • Genetic predisposition to stroke in spontaneously hypertensive rats
    • Nagaoka, A., Iwatsuka, H., Suzuoki, Z., Okamoto, K.: Genetic predisposition to stroke in spontaneously hypertensive rats. Am J Physiol. 1976; 230: 1354-1359.
    • (1976) Am J Physiol , vol.230 , pp. 1354-1359
    • Nagaoka, A.1    Iwatsuka, H.2    Suzuoki, Z.3    Okamoto, K.4
  • 35
    • 0016799197 scopus 로고
    • Plasma renin and hypertensive vascular complications: An observation in the stroke-prone spontaneously hypertensive rats
    • Matsunaga, M., Yamamoto, J., Hara, A., Yamori, Y., Ogino, K., Okamoto, K.: Plasma renin and hypertensive vascular complications: an observation in the stroke-prone spontaneously hypertensive rats. Jpn. Circ. J. 1975; 39: 1305-1311.
    • (1975) Jpn. Circ. J. , vol.39 , pp. 1305-1311
    • Matsunaga, M.1    Yamamoto, J.2    Hara, A.3    Yamori, Y.4    Ogino, K.5    Okamoto, K.6
  • 36
    • 0017813168 scopus 로고
    • Antihypertensive activity in rats of SQ14.225, an orally active inhibitor of angiotensin I-converting enzyme
    • Laffan, R.J., Goldberg, M.E., High, J.P., Schaeffer, T., Waugh, M.H., Rubin, B.: Antihypertensive activity in rats of SQ14.225, an orally active inhibitor of angiotensin I-converting enzyme. J Pharmacol Exp Ther. 1978; 204: 281-288.
    • (1978) J Pharmacol Exp Ther , vol.204 , pp. 281-288
    • Laffan, R.J.1    Goldberg, M.E.2    High, J.P.3    Schaeffer, T.4    Waugh, M.H.5    Rubin, B.6
  • 37
    • 0019422994 scopus 로고
    • Antihypertensive activity of N-[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor
    • Sweet, C.S., Gross, D.M., Arbegast, P.T., Gaul, S.L., Britt, P.M., Ludden, C.T., Weitz, D., Stone, C.A.: Antihypertensive activity of N-[(s)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-Ala-L-Pro (MK-421), an orally active converting enzyme inhibitor. J Pharmacol Exp Ther. 1981; 216: 558-566.
    • (1981) J Pharmacol Exp Ther , vol.216 , pp. 558-566
    • Sweet, C.S.1    Gross, D.M.2    Arbegast, P.T.3    Gaul, S.L.4    Britt, P.M.5    Ludden, C.T.6    Weitz, D.7    Stone, C.A.8
  • 38
    • 0022443525 scopus 로고
    • Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models
    • Inada, Y., Tanabe, M., Shibouta, Y., Kawazoe, K., Nishikawa, K., Kikuchi, S.: Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986; 42: 1-8.
    • (1986) Jpn J Pharmacol , vol.42 , pp. 1-8
    • Inada, Y.1    Tanabe, M.2    Shibouta, Y.3    Kawazoe, K.4    Nishikawa, K.5    Kikuchi, S.6
  • 39
    • 0020035802 scopus 로고
    • SA446, a new oralfy active converting enzyme inhibitor: Antihypertensive action and comparison with captopril in stroke-prone spontaneously hypertensive rats
    • Unger, T., Yukimura, T., Marin-Grez, M., Lang, R.E., Rascher, W., Ganten, D.: SA446, a new oralfy active converting enzyme inhibitor: antihypertensive action and comparison with captopril in stroke-prone spontaneously hypertensive rats. Eur J Pharmacol. 1982; 78: 411-420.
    • (1982) Eur J Pharmacol , vol.78 , pp. 411-420
    • Unger, T.1    Yukimura, T.2    Marin-Grez, M.3    Lang, R.E.4    Rascher, W.5    Ganten, D.6
  • 40
    • 0022238142 scopus 로고
    • Effects of enalapril and captopril on urinary excretion of kinins and electrolytes in stroke-prone spontaneously hypertensive rats
    • Kawashima, K., Kimura, M., Watanabe, TX., Sokabe, H., Kobayashi, Y.: Effects of enalapril and captopril on urinary excretion of kinins and electrolytes in stroke-prone spontaneously hypertensive rats. Jpn J Pharmacol. 1985; 39: 415-417.
    • (1985) Jpn J Pharmacol , vol.39 , pp. 415-417
    • Kawashima, K.1    Kimura, M.2    Watanabe, T.X.3    Sokabe, H.4    Kobayashi, Y.5
  • 41
    • 0022972562 scopus 로고
    • Antihypertensive action and inhibition of tissue converting enzyme (CE) by three prodrug CE inhibitors, enalapril, ramipril and perindopril in stroke-prone spontaneously hypertensive rats
    • Moursi, M.G., Ganten, D., Lang, R.E., Unger, T.: Antihypertensive action and inhibition of tissue converting enzyme (CE) by three prodrug CE inhibitors, enalapril, ramipril and perindopril in stroke-prone spontaneously hypertensive rats. J Hypertens. 1986; 4 (Suppl. 3): S495.
    • (1986) J Hypertens , vol.4 , Issue.3 SUPPL.
    • Moursi, M.G.1    Ganten, D.2    Lang, R.E.3    Unger, T.4
  • 42
    • 0020056898 scopus 로고
    • Angiotensin converting enzyme inhibition in tissue from spontaneously hypertensive rats after treatment with captopril or MK-421
    • Cohen, M.L., Kurz, K.D.: Angiotensin converting enzyme inhibition in tissue from spontaneously hypertensive rats after treatment with captopril or MK-421. J Pharmacol Exp Ther. 1982; 220: 63-69.
    • (1982) J Pharmacol Exp Ther , vol.220 , pp. 63-69
    • Cohen, M.L.1    Kurz, K.D.2
  • 43
    • 0021338073 scopus 로고
    • Vascular angiotensin-converting enzyme activity in man and other species
    • Miyazaki, M., Okunishi, H., Nishimura, K., Toda, N.: Vascular angiotensin-converting enzyme activity in man and other species. Clin Sci. 1984; 66: 39-45.
    • (1984) Clin Sci , vol.66 , pp. 39-45
    • Miyazaki, M.1    Okunishi, H.2    Nishimura, K.3    Toda, N.4
  • 44
    • 9844262686 scopus 로고
    • Converting enzyme inhibitors: Antihypertensive drugs with unexpected mechanisms
    • Unger, T., Ganten, D., Lang, R.E.: Converting enzyme inhibitors: antihypertensive drugs with unexpected mechanisms. Trends Pharmacol Sci. 1983; 4: 514-519.
    • (1983) Trends Pharmacol Sci , vol.4 , pp. 514-519
    • Unger, T.1    Ganten, D.2    Lang, R.E.3
  • 45
    • 0002162477 scopus 로고
    • Effects of angiotensin on the renal circulation
    • Page IH, Bumpus FM (eds) Springer-Verlag, New York
    • Navar, L.G., Langford, H.G.: Effects of angiotensin on the renal circulation. In: Page IH, Bumpus FM (eds) Angiotensin. Springer-Verlag, New York, 1974, p. 455.
    • (1974) Angiotensin , pp. 455
    • Navar, L.G.1    Langford, H.G.2
  • 46
    • 0023893548 scopus 로고
    • Cilazapril prevents the development of cardiac hypertrophy and the decrease of coronary vascular reserve in spontaneously hypertensive rats
    • Clozel, J.-P., Hefti, F.: Cilazapril prevents the development of cardiac hypertrophy and the decrease of coronary vascular reserve in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1988; 11: 568-572.
    • (1988) J Cardiovasc Pharmacol , vol.11 , pp. 568-572
    • Clozel, J.-P.1    Hefti, F.2
  • 47
    • 0040437788 scopus 로고
    • Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat
    • Pfeffer, J.M., Pfeffer, M.A., Mirsky, I., Braunwald, E.: Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acad Sci. USA. 1989; 79: 3310-3314.
    • (1989) Proc Natl Acad Sci USA , vol.79 , pp. 3310-3314
    • Pfeffer, J.M.1    Pfeffer, M.A.2    Mirsky, I.3    Braunwald, E.4
  • 48
    • 0020700931 scopus 로고
    • Regression of myocardial hypertrophy and influence of adrenergic system
    • Sen, S., Tarazi, C.: Regression of myocardial hypertrophy and influence of adrenergic system. Am J Physiol. 1983; 244: H97-H101.
    • (1983) Am J Physiol , vol.244
    • Sen, S.1    Tarazi, C.2
  • 49
    • 0024448370 scopus 로고
    • Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy
    • Linz, W., Scholkens, B.A., Ganten, D.: Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy. Clin Exp Hypertens. 1989; 11: 1325-1350.
    • (1989) Clin Exp Hypertens , vol.11 , pp. 1325-1350
    • Linz, W.1    Scholkens, B.A.2    Ganten, D.3
  • 50
    • 0015516389 scopus 로고
    • Role of blood pressure in the development of congestive heart failure. The Framingham Study
    • Kannel, W.B., Castelli, W.P., McNamara, P.M., McKee, P.A., Fenleib, M.: Role of blood pressure in the development of congestive heart failure. The Framingham Study. N Engl J Med. 1972; 287: 781-787.
    • (1972) N Engl J Med , vol.287 , pp. 781-787
    • Kannel, W.B.1    Castelli, W.P.2    McNamara, P.M.3    McKee, P.A.4    Fenleib, M.5
  • 51
    • 0026409556 scopus 로고
    • Differential regulation of angiotensin peptide levels in plasma and kidney of the rat
    • Campbell, D.J., Lawrence, A.C., Towrie, A., Kladis, A., Valentiju, A.J.: Differential regulation of angiotensin peptide levels in plasma and kidney of the rat Hypertension. 1991; 18: 763-773.
    • (1991) Hypertension , vol.18 , pp. 763-773
    • Campbell, D.J.1    Lawrence, A.C.2    Towrie, A.3    Kladis, A.4    Valentiju, A.J.5
  • 52
    • 0023279363 scopus 로고
    • Plasma angiotensins and blood pressure during converting enzyme inhibition
    • Mento, P.F., Wilkes, B.M.: Plasma angiotensins and blood pressure during converting enzyme inhibition. Hypertension. 1987; 9 [Suppl III]: 42-48.
    • (1987) Hypertension , vol.9 , Issue.3 SUPPL. , pp. 42-48
    • Mento, P.F.1    Wilkes, B.M.2
  • 53
    • 0025239660 scopus 로고
    • Angiotensin II-forming pathways in normal and failing human hearts
    • Urata, H., Healy, B., Stewart, RW., Bumpus, FM, Husain, A.: Angiotensin II-forming pathways in normal and failing human hearts. Circ Res. 1990; 60:883-890.
    • (1990) Circ Res , vol.60 , pp. 883-890
    • Urata, H.1    Healy, B.2    Stewart, R.W.3    Bumpus, F.M.4    Husain, A.5
  • 54
    • 0025176910 scopus 로고
    • Conversion of angiotensin I to angiotensin H in dog isolated renal artery: Role of two different angiotensin II-generating enzymes
    • Okamura, T., Okunishi, H., Ayajiki, K. and Toda, N.: Conversion of angiotensin I to angiotensin H in dog isolated renal artery: role of two different angiotensin II-generating enzymes. J Cardiovasc Pharmacol. 1990; 15:353-359.
    • (1990) J Cardiovasc Pharmacol , vol.15 , pp. 353-359
    • Okamura, T.1    Okunishi, H.2    Ayajiki, K.3    Toda, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.