The angiotensin AT2 receptor down-regulates neurofilament M in PC12W cells

Neuroscience Letters

Volumn 227, Issue 1, 1997, Pages 29-32

  Gallinat, Stefan ^a,b   Csikos, Tamas ^a,b   Meffert, Simone ^a,b   Herdegen, Thomas ^a   Stoll, Monika ^a,b   Unger, Thomas ^a,b  

^a UNIVERSITY OF KIEL   (Germany)

^b German Institute for High Blood Pressure Research   (Germany)

Author keywords

Angiotensin; AT2 receptors; Losartan; Nerve growth factor (NGF); Neurite extension; PC12W cells; PD123177

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; NERVE GROWTH FACTOR; NEUROFILAMENT PROTEIN; PROTEIN SUBUNIT; ANGIOTENSIN RECEPTOR; BIPHENYL DERIVATIVE; IMIDAZOLE DERIVATIVE; LOSARTAN; TETRAZOLE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; MOLECULAR DYNAMICS; NERVE CELL CULTURE; NERVE FIBER GROWTH; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; ANIMAL; CELL DIFFERENTIATION; CELL STRAIN; DOWN REGULATION; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; METABOLISM; METHODOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RAT; STATISTICAL MODEL;

ANIMALS; BIPHENYL COMPOUNDS; CELL DIFFERENTIATION; DOWN-REGULATION; IMIDAZOLES; LINEAR MODELS; LOSARTAN; NEUROFILAMENT PROTEINS; PC12 CELLS; POLYMERASE CHAIN REACTION; RATS; RECEPTORS, ANGIOTENSIN; TETRAZOLES; TRANSCRIPTION, GENETIC;

EID: 0030610222     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00291-7     Document Type: Article

References (18)

1. Bleuel A., de Gasparo M., Whitebread S., Puttner I., Monard D. Regulation of protease nexin-1 expression in cultured Schwann cells is mediated by angiotensin II receptors. J. Neurosci. 15:1995;750-761.
2. 2 receptor stimulates phosphotyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem. Biophys. Res. Commun. 183:1992;206-211.
3. Estus S., Zaks W.J., Freeman R.S., Gruda M., Bravo R., Johnson E.M. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127:1994;1717-1727.
4. Goldstein M.E., Sternberger N.H., Sternberger L.A. Phosphorylation protects neurofilaments against proteolysis. J. Neuroimmunol. 14:1987;149-160.
5. 2 receptors in the developing rat fetus. J. Clin. Invest. 88:1991;921-933.
6. Hoffman P.N., Cleveland D.W. Neurofilament and tubulin expression recapitulates the development program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc. Natl. Acad. Sci. USA. 85:1988;4530-4533.
7. 2 receptors in NG108-15 cells. J. Biol. Chem. 271:1996;22729-22735.
8. Lee V., Trojanowski J.Q., Schlaepfer W.W. Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor. Brain Res. 238:1982;169-180.
9. Lee M.K., Cleveland D.W. Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease. Curr. Opin. Cell Biol. 6:1994;34-40.
10. Lindenbaum M.H., Carbonetto S., Grosveld F., Flavell D., Mushynski W.E. Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC12 cells. J. Biol. Chem. 263:1988;5662-5667.
11. 2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol. Cell. Endocrinol. 122:1996;59-67.
12. Napolitano E.W., Chin S.S.M., Colman D.R., Liem R.K.H. Complete amino acid sequence and in vitro expression of rat NF-M, the middle molecular weight neuro-filament protein. J. Neurosci. 7:1987;2590-2599.
13. Ponte P., Ng S.Y., Engel J., Gunning P., Kedes L. Evolutionary conservation in the untranslated region of actin mRNAs. Nucleic Acids Res. 12:1984;1687-1696.
14. Solomon F. Direct identification of microtubule-associated proteins by selective extraction of cultured cells. Methods Enzymol. 134:1986;139-147.
15. 2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 95:1995;651-657.
16. Timmermans P.B.M.W.M., Wong P.C., Chiu A.T., Herblin W.F., Benfield P., Carini D.J., Lee R.J., Wexler R.R., Saye J.A.M., Smith R.D. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45:1993;205-251.
17. 125I]CGP42112 binding site in healing wounds of rat brain. Brain Res. 658:1994;265-270.
18. Yamada T., Horiuchi M., Dzau V.J. Angiotensin II type 2 receptor mediates programmed cell death. Proc. Natl. Acad. Sci. USA. 93:1996;156-160.