메뉴 건너뛰기




Volumn 3, Issue 3, 2001, Pages 201-206

Gene therapy of severe combined immunodeficiencies

Author keywords

Clinical trials; Gene therapy of hematopoietic disorders; Hematopoietic stem cells; Primary immunodeficiencies; Retrovirus; Severe combined immunodeficiencies (SCID)

Indexed keywords

UNIDENTIFIED RETROVIRUS;

EID: 0035345136     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-2254(200105/06)3:3<201::AID-JGM195>3.0.CO;2-Z     Document Type: Review
Times cited : (46)

References (50)
  • 1
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: Units of development, units of regeneration, and units in evolution
    • Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000; 100: 157-168.
    • (2000) Cell , vol.100 , pp. 157-168
    • Weissman, I.L.1
  • 2
    • 0033152360 scopus 로고    scopus 로고
    • Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34+ cord blood cells after ex vivo expansion: Evidence for the amplification and self-renewal of repopulating stem cells
    • Piacibello W, Sanavio F, Severino A, et al. Engraftment in nonobese diabetic severe combined immunodeficient mice of human CD34+ cord blood cells after ex vivo expansion: evidence for the amplification and self-renewal of repopulating stem cells. Blood 1999; 93: 3736-3749.
    • (1999) Blood , vol.93 , pp. 3736-3749
    • Piacibello, W.1    Sanavio, F.2    Severino, A.3
  • 3
    • 0029977501 scopus 로고    scopus 로고
    • Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: Novel responses to Flt3-ligand and thrombopoietin
    • Petzer AL, Zandstra PW, Piret JM, et al. Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin. J Exp Med 1996; 183: 2551-2558.
    • (1996) J Exp Med , vol.183 , pp. 2551-2558
    • Petzer, A.L.1    Zandstra, P.W.2    Piret, J.M.3
  • 4
    • 0031157028 scopus 로고    scopus 로고
    • Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+CD38-) human bone marrow progenitor cells: Distinct and key interactions with the ligands for c -kit and Flt-3 and inhibitory effects of TGF-beta and TNF-alpha
    • Ramsfjell V, Borge OJ, Cui L, et al. Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive (CD34+CD38-) human bone marrow progenitor cells: distinct and key interactions with the ligands for c -kit and Flt-3 and inhibitory effects of TGF-beta and TNF-alpha. J Immunol 1997; 158: 5169-5177.
    • (1997) J Immunol , vol.158 , pp. 5169-5177
    • Ramsfjell, V.1    Borge, O.J.2    Cui, L.3
  • 6
    • 0034064779 scopus 로고    scopus 로고
    • Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
    • Kung C, Pingel JT, Heikinheimo M, et al. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med 2000; 6: 343-345.
    • (2000) Nat Med , vol.6 , pp. 343-345
    • Kung, C.1    Pingel, J.T.2    Heikinheimo, M.3
  • 7
    • 0031723552 scopus 로고    scopus 로고
    • Adenosine deaminase deficiency: Clinical expression, molecular basis and therapy
    • Hershfield MS. Adenosine deaminase deficiency: clinical expression, molecular basis and therapy. Semin Hematol 1998; 35: 291-298.
    • (1998) Semin Hematol , vol.35 , pp. 291-298
    • Hershfield, M.S.1
  • 8
    • 0026758198 scopus 로고
    • Insulin-dependent diabetes mellirus and severe atopic dermatitis in a child with adenosine deaminase deficiency
    • Notarangelo LD, Stoppoloni G, Toraldo R, et al. Insulin-dependent diabetes mellirus and severe atopic dermatitis in a child with adenosine deaminase deficiency. Eur J Pediatr 1992; 151: 811-814.
    • (1992) Eur J Pediatr , vol.151 , pp. 811-814
    • Notarangelo, L.D.1    Stoppoloni, G.2    Toraldo, R.3
  • 9
    • 0028807727 scopus 로고
    • T Lymphocyte-directed gene therapy for ADA-SCID: Initial trial results after 4 years
    • Blaese RM, Culver KW, Miller AD, et al. T Lymphocyte-directed gene therapy for ADA-SCID: initial trial results after 4 years. Science 1995; 270: 475-480.
    • (1995) Science , vol.270 , pp. 475-480
    • Blaese, R.M.1    Culver, K.W.2    Miller, A.D.3
  • 10
    • 9244243165 scopus 로고    scopus 로고
    • Bone marrow gene transfer in three patients with adenosine deaminase deficiency
    • Hoogerbrugge PM, Beusechem VW, Fischer A, et al. Bone marrow gene transfer in three patients with adenosine deaminase deficiency. Gene Ther 1996; 3: 179-183.
    • (1996) Gene Ther , vol.3 , pp. 179-183
    • Hoogerbrugge, P.M.1    Beusechem, V.W.2    Fischer, A.3
  • 11
    • 0028789792 scopus 로고
    • Gene therapy in peripheral blood lymphocytes and bone marrow for ADA immunodeficient patients
    • Bordignon C, Notarangelo LD, Nobili N, et al. Gene therapy in peripheral blood lymphocytes and bone marrow for ADA immunodeficient patients. Science 1995; 270: 470-475.
    • (1995) Science , vol.270 , pp. 470-475
    • Bordignon, C.1    Notarangelo, L.D.2    Nobili, N.3
  • 12
    • 0346498974 scopus 로고    scopus 로고
    • Successful long-term PBL gene therapy for ADA deficient SCID in the absence of PEG-ADA
    • Bordignon C, Bali P, Hershfield M, et al. Successful long-term PBL gene therapy for ADA deficient SCID in the absence of PEG-ADA. J Gene Med 2000; 2 (Suppl.): 5-26.
    • (2000) J Gene Med , vol.2 , Issue.SUPPL. , pp. 5-26
    • Bordignon, C.1    Bali, P.2    Hershfield, M.3
  • 13
    • 0028864561 scopus 로고
    • Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency
    • Kohn DB, Weinberg KI, Nolta JA, et al. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nat Med 1995; 1: 1017-1023.
    • (1995) Nat Med , vol.1 , pp. 1017-1023
    • Kohn, D.B.1    Weinberg, K.I.2    Nolta, J.A.3
  • 14
    • 0031593688 scopus 로고    scopus 로고
    • T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA deficient SCID neonates
    • Kohn DB, Hershfield MS, Carbonaro D, et al. T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA deficient SCID neonates. Nat Med 1998; 4: 775-780.
    • (1998) Nat Med , vol.4 , pp. 775-780
    • Kohn, D.B.1    Hershfield, M.S.2    Carbonaro, D.3
  • 15
    • 0023442485 scopus 로고
    • Close linkage of the locus for X chromosome linked severe combined immunodeficiency to polymorphic DNA markers in Xq 11-Xq 113
    • de Saint Basile G, Arveiler B, Oberle I, et al. Close linkage of the locus for X chromosome linked severe combined immunodeficiency to polymorphic DNA markers in Xq 11-Xq 113. Proc Natl Acad Sci U S A 1987; 84: 7576-7579.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 7576-7579
    • De Saint Basile, G.1    Arveiler, B.2    Oberle, I.3
  • 16
    • 0027403374 scopus 로고
    • Interleukin-2 receptor gamma c chain mutation results in X-linked severe combined immunodeficiency in humans
    • Noguchi M, Yi H, Rosenblatt HM, et al. Interleukin-2 receptor gamma c chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993; 73: 147-157.
    • (1993) Cell , vol.73 , pp. 147-157
    • Noguchi, M.1    Yi, H.2    Rosenblatt, H.M.3
  • 17
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000; 408: 57-63.
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1    Dillon, S.R.2    Nelson, A.3
  • 18
    • 0029414787 scopus 로고
    • Common cytokine receptor gamma chain (gamma c)-dependent cytokines understanding in vivo functions by gene targeting
    • Di Santo JP, Kühn R, Muller W. Common cytokine receptor gamma chain (gamma c)-dependent cytokines understanding in vivo functions by gene targeting. Immunol Rev 1995; 148: 19-34.
    • (1995) Immunol Rev , vol.148 , pp. 19-34
    • Di Santo, J.P.1    Kühn, R.2    Muller, W.3
  • 19
    • 0029850719 scopus 로고    scopus 로고
    • Role of interleukin-2 (IL-2), IL-7 and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency - X1 bone marrow cells
    • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, et al. Role of interleukin-2 (IL-2), IL-7 and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency - X1 bone marrow cells. Blood 1996; 88: 3901-3909.
    • (1996) Blood , vol.88 , pp. 3901-3909
    • Cavazzana-Calvo, M.1    Hacein-Bey, S.2    De Saint Basile, G.3
  • 20
    • 0001765799 scopus 로고    scopus 로고
    • γc Gene transfer into SCID XI patients B-cell lines restores normal high-affinity IL2 receptor expression and function
    • Hacein-Bey S, Cavazzana-Calvo M, Le Deist F, et al. γc Gene transfer into SCID XI patients B-cell lines restores normal high-affinity IL2 receptor expression and function. Blood 1996; 87: 6108-6116.
    • (1996) Blood , vol.87 , pp. 6108-6116
    • Hacein-Bey, S.1    Cavazzana-Calvo, M.2    Le Deist, F.3
  • 21
    • 0032237804 scopus 로고    scopus 로고
    • γc Gene transfer in the presence of stem cell factor, FLT-3L, interleukin-7 (IL-7), IL-1, and IL-15 cytokines restores T cell differentiation from gamma c (-) X-linked severe combined immunodeficient hematopoietic progenitor cells in murine fetal thymic organ cultures
    • Hacein-Bey S, de Saint Basile G, Lemerle J, Fischer A, Cavazzana-Calvo M. γc Gene transfer in the presence of stem cell factor, FLT-3L, interleukin-7 (IL-7), IL-1, and IL-15 cytokines restores T cell differentiation from gamma c (-) X-linked severe combined immunodeficient hematopoietic progenitor cells in murine fetal thymic organ cultures. Blood 1998; 92: 4090-4097.
    • (1998) Blood , vol.92 , pp. 4090-4097
    • Hacein-Bey, S.1    De Saint Basile, G.2    Lemerle, J.3    Fischer, A.4    Cavazzana-Calvo, M.5
  • 22
    • 0034657369 scopus 로고    scopus 로고
    • Stable and functional lymphoid reconstitution common cytokine receptor gamma chain deficient mice by retroviral-mediated gene transfer
    • Soudais C, Shiho T, Sharara LI, et al. Stable and functional lymphoid reconstitution common cytokine receptor gamma chain deficient mice by retroviral-mediated gene transfer. Blood 2000; 95: 3071-3077.
    • (2000) Blood , vol.95 , pp. 3071-3077
    • Soudais, C.1    Shiho, T.2    Sharara, L.I.3
  • 23
    • 0029962080 scopus 로고    scopus 로고
    • The interleukin-2 receptor gamma chain: Its role in the multiple cytokine receptor complexes and T cell development in X SCID
    • Sugamura K, Asao H, Kondo M, et al. The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in X SCID. Annu Rev Immunol 1996; 14: 179-205.
    • (1996) Annu Rev Immunol , vol.14 , pp. 179-205
    • Sugamura, K.1    Asao, H.2    Kondo, M.3
  • 24
    • 0030008035 scopus 로고    scopus 로고
    • Retroviral-mediated gene correction for X-linked severe combined immunodeficiency
    • Candotti F, Johnston JA, Puck JM, et al. Retroviral-mediated gene correction for X-linked severe combined immunodeficiency. Blood 1996; 87: 3097-3102.
    • (1996) Blood , vol.87 , pp. 3097-3102
    • Candotti, F.1    Johnston, J.A.2    Puck, J.M.3
  • 25
    • 0029866741 scopus 로고    scopus 로고
    • Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene
    • Taylor N, Uribe L, Smith S, et al. Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene. Blood 1996; 87: 3103-3107.
    • (1996) Blood , vol.87 , pp. 3103-3107
    • Taylor, N.1    Uribe, L.2    Smith, S.3
  • 26
    • 0034724857 scopus 로고    scopus 로고
    • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
    • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000; 288: 669-672.
    • (2000) Science , vol.288 , pp. 669-672
    • Cavazzana-Calvo, M.1    Hacein-Bey, S.2    De Saint Basile, G.3
  • 27
    • 0345868211 scopus 로고    scopus 로고
    • Stem cell gene therapy for X-Iinked severe combined immunodeficiency mice expressing a truncated common gamma chain
    • 25-29 September
    • Otsu M, Sugamura K, Candotti F, et al. Stem cell gene therapy for X-Iinked severe combined immunodeficiency mice expressing a truncated common gamma chain. Paper presented at the Cold Spring Harbor Meeting on Gene Therapy, 25-29 September 2000.
    • (2000) Cold Spring Harbor Meeting on Gene Therapy
    • Otsu, M.1    Sugamura, K.2    Candotti, F.3
  • 28
    • 0035835375 scopus 로고    scopus 로고
    • Optimization of retroviral gene transfer protocol to maintain the lymphoid potential of progenitor cells
    • Hacein-Bey S, Gross F, Nusbaum P, et al. Optimization of retroviral gene transfer protocol to maintain the lymphoid potential of progenitor cells. Hum Gene Ther 2001; 12: 291-301.
    • (2001) Hum Gene Ther , vol.12 , pp. 291-301
    • Hacein-Bey, S.1    Gross, F.2    Nusbaum, P.3
  • 29
    • 0034663151 scopus 로고    scopus 로고
    • A ligand-receptor signaling threshold model of stem cell differentiation control: A biologically conserved mechanism applicable to hematopoiesis
    • Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis. Blood 2000; 96: 1215-1222.
    • (2000) Blood , vol.96 , pp. 1215-1222
    • Zandstra, P.W.1    Lauffenburger, D.A.2    Eaves, C.J.3
  • 30
    • 16044366110 scopus 로고    scopus 로고
    • Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells
    • Hanenberg H, Xiao XL, Dilloo D, et al. Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nat Med 1996; 2: 876-882.
    • (1996) Nat Med , vol.2 , pp. 876-882
    • Hanenberg, H.1    Xiao, X.L.2    Dilloo, D.3
  • 31
    • 0033229710 scopus 로고    scopus 로고
    • Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach
    • Lo M, Bloom ML, Imada K, et al. Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach. Blood 1999; 94: 3027-3036.
    • (1999) Blood , vol.94 , pp. 3027-3036
    • Lo, M.1    Bloom, M.L.2    Imada, K.3
  • 32
    • 0032170429 scopus 로고    scopus 로고
    • Retroviral marking of canine bone marrow: Long-term, high-level expression of human interleukin-2 receptor common gamma chain in canine lymphocytes
    • Whitwam T, Haskins ME, Henthorn PS, et al. Retroviral marking of canine bone marrow: long-term, high-level expression of human interleukin-2 receptor common gamma chain in canine lymphocytes. Blood 1998; 92: 1565-1575.
    • (1998) Blood , vol.92 , pp. 1565-1575
    • Whitwam, T.1    Haskins, M.E.2    Henthorn, P.S.3
  • 33
    • 0010394482 scopus 로고    scopus 로고
    • Gene therapy of human severe combined immunodeficiency (SCID)-X 1 disease
    • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, et al. Gene therapy of human severe combined immunodeficiency (SCID)-X 1 disease. Blood 2000; 96 (Suppl. 11): 590.
    • (2000) Blood , vol.96 , Issue.11 SUPPL. , pp. 590
    • Cavazzana-Calvo, M.1    Hacein-Bey, S.2    De Saint Basile, G.3
  • 34
    • 0034232490 scopus 로고    scopus 로고
    • γ Chain required for naive CD4+ T cell survival but not for antigen proliferation
    • Lantz O, Grandjean I, Matzinger P, et al. γ Chain required for naive CD4+ T cell survival but not for antigen proliferation. Nat Immunol 2000; 1: 54-58.
    • (2000) Nat Immunol , vol.1 , pp. 54-58
    • Lantz, O.1    Grandjean, I.2    Matzinger, P.3
  • 35
    • 0034604048 scopus 로고    scopus 로고
    • Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency
    • Patel DD, Gooding ME, Parrott RE, et al. Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med 2000; 342: 1325-1332.
    • (2000) N Engl J Med , vol.342 , pp. 1325-1332
    • Patel, D.D.1    Gooding, M.E.2    Parrott, R.E.3
  • 36
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi P, Villa A, Gillani S, et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 1995; 377: 65-68.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Gillani, S.3
  • 37
    • 0031740732 scopus 로고    scopus 로고
    • Defective IL-7 R expression in T (-) B (+) NK (+) severe combined immunodeficiency
    • Puel A, Ziegler SF, Buckley RH, et al. Defective IL-7 R expression in T (-) B (+) NK (+) severe combined immunodeficiency. Nat Genet 1998; 20: 394-397.
    • (1998) Nat Genet , vol.20 , pp. 394-397
    • Puel, A.1    Ziegler, S.F.2    Buckley, R.H.3
  • 38
    • 0031890632 scopus 로고    scopus 로고
    • Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer
    • Bunting KD, Sangster MY, Ihle JN, et al. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nat Med 1998; 4: 58-64.
    • (1998) Nat Med , vol.4 , pp. 58-64
    • Bunting, K.D.1    Sangster, M.Y.2    Ihle, J.N.3
  • 39
    • 10144253125 scopus 로고    scopus 로고
    • RAG mutations in human B cell-negative SCID
    • Schwarz K, Gauss GH, Ludwig L, et al. RAG mutations in human B cell-negative SCID. Science 1996; 274: 97-99.
    • (1996) Science , vol.274 , pp. 97-99
    • Schwarz, K.1    Gauss, G.H.2    Ludwig, L.3
  • 41
    • 0034724676 scopus 로고    scopus 로고
    • Three-dimensional clustering of human RAG 2 gene mutations in severe combined immune deficiency
    • Corneo B, Moshous D, Callebaut I, et al. Three-dimensional clustering of human RAG 2 gene mutations in severe combined immune deficiency. J Biol Chem 2000; 275: 12672-12675.
    • (2000) J Biol Chem , vol.275 , pp. 12672-12675
    • Corneo, B.1    Moshous, D.2    Callebaut, I.3
  • 42
    • 10544250248 scopus 로고    scopus 로고
    • Reconstitution of T cell receptor signaling in ZAP-70 deficient cells by retroviral transduction of the ZAP-70 gene
    • Taylor N, Bacon KB, Smith S, et al. Reconstitution of T cell receptor signaling in ZAP-70 deficient cells by retroviral transduction of the ZAP-70 gene. J Exp Med 1996; 184: 2031-2036.
    • (1996) J Exp Med , vol.184 , pp. 2031-2036
    • Taylor, N.1    Bacon, K.B.2    Smith, S.3
  • 43
    • 0031787859 scopus 로고    scopus 로고
    • Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice
    • Brown MP, Topham DJ, Sangster MY, et al. Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice. Nat Med 1998; 11: 1253-1260.
    • (1998) Nat Med , vol.11 , pp. 1253-1260
    • Brown, M.P.1    Topham, D.J.2    Sangster, M.Y.3
  • 44
    • 0343628721 scopus 로고    scopus 로고
    • Therapeutic haemoglobin synthesis in β-thalassemic mice expressing lentivirus-encoded human β-globin
    • May C, Rivella S, Callegari J, et al. Therapeutic haemoglobin synthesis in β-thalassemic mice expressing lentivirus-encoded human β-globin. Nature 2000; 406: 82-84.
    • (2000) Nature , vol.406 , pp. 82-84
    • May, C.1    Rivella, S.2    Callegari, J.3
  • 45
    • 0030669613 scopus 로고    scopus 로고
    • Gene transfer into marrow repopulating cells: Comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons
    • Kiem HP, Heyward S, Winkler A, et al. Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive repopulation assay in baboons. Blood 1997; 90: 4638-4645.
    • (1997) Blood , vol.90 , pp. 4638-4645
    • Kiem, H.P.1    Heyward, S.2    Winkler, A.3
  • 46
    • 0033120735 scopus 로고    scopus 로고
    • One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-liter vesicular stomatitis virus G protein pseudotyped retrovirus
    • Rebel VI, Tanaka M, Lee JS, et al. One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-liter vesicular stomatitis virus G protein pseudotyped retrovirus. Blood 1999; 93: 2217-2224.
    • (1999) Blood , vol.93 , pp. 2217-2224
    • Rebel, V.I.1    Tanaka, M.2    Lee, J.S.3
  • 47
    • 0000244929 scopus 로고    scopus 로고
    • Multilineage transduction of non-human primate CD34+ hematopoietic cells using RD-1 14 pseudotyped oncoretroviruses
    • Kelly PF, Bonifacinot AC, Vandergriff JA. Multilineage transduction of non-human primate CD34+ hematopoietic cells using RD-1 14 pseudotyped oncoretroviruses. Mol Ther 2000; 1 (Suppl.): 125.
    • (2000) Mol Ther , vol.1 , Issue.SUPPL. , pp. 125
    • Kelly, P.F.1    Bonifacinot, A.C.2    Vandergriff, J.A.3
  • 48
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 49
    • 0034646513 scopus 로고    scopus 로고
    • HIV-1 genome nuclear import is mediated by a central DNa flap
    • Zennou V, Petit C, Guetard D, et al. HIV-1 genome nuclear import is mediated by a central DNA flap. Cell 2000; 101: 173-185.
    • (2000) Cell , vol.101 , pp. 173-185
    • Zennou, V.1    Petit, C.2    Guetard, D.3
  • 50
    • 0033613827 scopus 로고    scopus 로고
    • Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors
    • Miyoshi H, Smith KA, Mosier DE, et al. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Science 1999; 283: 682-686.
    • (1999) Science , vol.283 , pp. 682-686
    • Miyoshi, H.1    Smith, K.A.2    De Mosier3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.