Phosphorylation of Sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation

Molecular Biology of the Cell

Volumn 9, Issue 9, 1998, Pages 2393-2405

  Nishizawa, Masafumi ^a   Kawasumi, Masaoki ^a   Fujino, Marie ^b   Toh e, Akio ^b  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; DNA; GLUTATHIONE TRANSFERASE; MUTANT PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPLICATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0031671237     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.9.2393     Document Type: Article

References (49)

1. Aerne, B.L., Johnson, A.L., Toyn, J.H., and Johnston, L.H. (1998). Swi5 controls a novel wave of cyclin synthesis in late mitosis. Mol. Biol. Cell 9, 945-956.
2. Cismowski, M.J., Laff, G.M., Solomon, M.J., and Reed, S.I. (1995). KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. Mol. Cell. Biol. 15, 2983-2992.
3. CDC28 (Cdc28p) in vitro. Proc. Natl. Acad. Sci. USA 92, 1182-1186.
4. Dirick, L., Bohm, T., and Nasmyth, K. (1995). Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14, 4803-4813.
5. Epstein, C.B., and Cross, F.R. (1992). CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev. 6, 1695-1706.
6. Espinoza, F.H., Ogas, J., Herskowitz, I., and Morgan, D.O. (1994). Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science 266, 1388-1391.
7. Feldman, R.M.R., Correll, C.C., Kaplan, K.B., and Deshaies, R.J. (1997). A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91, 221-230.
8. Fujino, M., Nishizawa, M., Yoon, S.-J., Oguchi, T., and Toh-e, A. (1994). Characterization of Pho85 kinase of Saccharomyces cerevisiae, In: Phosphate in Microorganisms: Cellular and Molecular Biology, ed. A. Torriani-Gorini, S. Silver, and E. Yagil, Washington, DC: American Society for Microbiology, 70-75.
9. Hartwell, L.H., Culotti, J., Pringle, J.R., and Reid, B.J. (1974). Genetic control of the cell division cycle in yeast. Science 183, 46-51.
10. Hereford, L.M. (1974). Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis. J. Mol. Biol. 84, 445-461.
11. Huang, D., Farkas, I., and Roach, P.J. (1996). Pho85p, a cyclin-dependent protein kinase, and the Snf1p protein kinase act antagonistically to control glycogen accumulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 4357-4365.
12. Johnston, M., and Davis, R.W. (1984). Sequences that regulate the divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae. Mol. Cell. Biol. 4, 1440-1448.
13. Kaffman, A., Herskowitz, I., Tjian, R., and O'Shea, E.K. (1994). Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science 263, 1153-1156.
14. Killander, G., and Zetterberg, A. (1965). A quantitative cytochemical investigation of the relationship between cell mass and initiation of DNA synthesis in mouse fibroblasts in vitro. Exp. Cell Res. 40, 12-20.
15. Kerch, C., Mountain, H.A., and Bystrom, A.S. (1991). Cloning, nucleotide sequence, and regulation of MET14, the gene encoding the APS kinase of Saccharomyces cerevisiae. Mol. Gen. Genet. 229, 96-108.
16. Liao, S.-M., Zhang, J., Jeffery, D.A., Koleske, A.J., Thompson, C.M., Chao, D.M., Viljoen, M., Vuuren, H.J.J.v., and Young, R.A. (1995). A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374, 193-196.
17. Measday, V., Moore, L., Ogas, J., Tyers, M., and Andrews, B. (1994). The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Science 266, 1391-1395.
18. Measday, V., Moore, L., Rernakaran, R., Lee, J., Donoviel, M., Neiman, A.M., and Andrews, B. (1997). A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol. Cell. Biol. 17, 1212-1223.
19. CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259, 216-219.
20. Morgan, D.O. (1995). Principles of CDK regulation. Nature 374, 131-134.
21. Nasmyth, K. (1993). Control of the yeast cell cycle. Curr. Opin. Cell Biol. 5, 166-179.
22. Nasmyth, K., and Dirick, L. (1991). The role of SW14 and SW16 in the activity of G1 cyclins in yeast. Cell 66, 995-1013.
23. Nigg, E.A. (1995). Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17, 471-480.
24. Nishizawa, M., Taga, S., and Matsubara, A. (1994). Positive and negative transcriptional regulation by the yeast GAL11 protein depends on the structure of the promoter and a combination of cis elements. Mol. Gen. Genet. 245, 301-312.
25. Ogas, J., Andrews, B.J., and Herskowitz, I. (1991). Transcriptional activation of CLN1, CLN2 and a putative new G1 cyclin (HCS26) by SW14, a positive regulator of G1-specific transcription. Cell 66, 1015-1026.
26. Ogawa, N., Noguchi, K., Sawai, H., Yamashita, Y., Yompakdee, C., and Oshima, Y. (1995). Functional domains of Pho81p, an inhibitor of Pho85p protein kinase, in the transcription pathway of Pi signals in Saccharomyces cerevisiae. Mol. Cell. Biol. 15, 997-1004.
27. O'Neill, E.M., Kaffman, A., Jolly, E.R., and O'Shea, E.K. (1996). Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Science 271, 209-212.
28. 2. Genes Dev. 6, 2021-2034.
29. Richardson, H.E., Wittenberg, C., Cross, F., and Reed, S.I. (1989). An essential G1 function for cyclin-like proteins in yeast. Cell 59, 1127-1133.
30. Rose, M.D., Winston, F., and Hieter, P. (1990). Methods in Yeast Genetics. A Laboratory Course Manual, Cold Spring Harbor, NY: Cold Harbor Spring Laboratory.
31. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning, A Laboratory Manual, 2nd ed., Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
32. Schneider, B.L., Yang, Q.H., and Futcher, A.B. (1996). Linkage of replication to start by the Cdk inhibitor Sic1. Science 272, 560-562.
33. SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244.
34. Schwob, E., and Nasmyth, K. (1993). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7, 1160-1175.
35. Skowyra, D., Craig, K.L., Tyers, M., Elledge, S.J., and Harper, J.W. (1997). F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219.
36. Stuart, D., and Wittenberg, C. (1995). CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells. Genes Dev. 9, 2780-2794.
37. Studier, F.W., Rosenberg, A.H., Dunn, J.J., and Dubendorf, J.W. (1990). Use of T7 RNA polymerase to direct the expression of cloned genes. Methods Enzymol. 185, 60-89.
38. Surana, U., Robitsch, H., Price, C., Schuster, T., Fitch, I., Futcher, B., and Nasmyth, K. (1991). The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65, 145-161.
39. Tanaka, K., Nakafuku, M., Tamanoi, F., Kajiro, Y., Matsumoto, K., and Toh-e, A. (1990). IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol. Cell. Biol. 10, 4303-4313.
40. Toh-e, A., Ueda, Y., Kakimoto, S., and Oshima, Y. (1973). Isolation and characterization of acid phosphatase mutants in Saccharomyces cerevisiae. J. Bacteriol. 113, 727-738.
41. Tyers, M. (1996). The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start. Proc. Natl. Acad. Sci. USA 93, 7772-7776.
42. Tyers, M., Tokiwa, G., and Futcher, B. (1993). Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12, 1955-1968.
43. Uesono, Y., Tanaka, K., and Toh-e, A. (1987). Negative regulators of the PHO system in Saccharomyces cerevisiae: isolation and structural characterization of PHO85. Nucleic Acids Res. 15, 10299-10309.
44. Valay, J.G., Simon, M., Dubois, M.F., Bensaude, O., Facca, C., and Faye, G. (1995). The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rbp1p CTD. J. Mol. Biol. 249, 535-544.
45. Valey, J.G., Simon, M., and Faye, G. (1993). The Kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae. J. Mol. Biol. 234, 307-310.
46. Verma, R., Annan, R.S., Huddleston, M.J., Carr, S.A., Reynard, G., and Deshaies, R.J. (1997a). Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278, 455-460.
47. Verma, R., Feldman, R.M.R., and Deshaies, R.J. (1997b). Sic1 is ubiquitinated in vitro by a pathway that requires Cdc4, Cdc34, and cyclin/Cdk activities. Mol. Biol. Cell 8, 1427-1437.
48. Willems, A.R., Lanker, S., Patton, E.E., Craig, K.L., Nason, T.F., Mathias, N., Kobayashi, R., Wittenberg, C., and Tyers, M. (1996). Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86, 453-463.
49. Wittenberg, C., and Reed, S.I. (1988). Control of the yeast cell cycle is associated with assembly/disassembly of the Cdc28 protein kinase complex. Cell 54, 1061-1072.