Transcriptional activation: Risky business

Genes and Development

Volumn 15, Issue 9, 2001, Pages 1045-1050

  Tansey, W P ^a  

^a Watson School of Biological Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA POLYMERASE; RNA POLYMERASE II;

GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; HUMANS; PROTEIN KINASES; RNA POLYMERASE II; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0035336896     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.896501     Document Type: Review

References (39)

1. Monitoring the Gcn4 protein-mediated response in the yeast Saccharomyces cerevisiae
2. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase
3. Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
4. TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74
5. The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex
6. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
7. Negative effect of the transcriptional activator GAL4
8. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway
9. Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
10. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast
11. Association of an activator with an RNA polymerase II holoenzyme
12. Evidence for translational regulation of the activator of general amino acid control in yeast
13. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8
14. Ubiquitin-dependent protein degradation
15. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
16. Regulation of interferon-γactivated STAT1 by the ubiquitin-proteasome pathway
17. Regulated degradation of the transcription factor Gcn4
18. An activator binding module of yeast RNA polymerase II holoenzyme
19. A kinase-cyclin pair in the RNA polymerase II holoenzyme
20. Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
21. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)
22. Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex
23. Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo
24. Multiple upstream AUG codons mediate translational control of GCN4
25. How eukaryotic transcriptional activators work
26. Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: Implications for activation of the protein kinase GCN2
27. Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
28. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis
29. The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae
30. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex [see comments]
31. The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous
32. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
33. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
34. Degradation of c-Fos by the 265 proteasome is accelerated by c-Jun and multiple protein kinases
35. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
36. Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase
37. The ubiquitin system
38. A small amphipathic α-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5
39. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor microphthalmia