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1
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0031559401
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Unified nomenclature for Eph family receptors and their ligands, the ephrins
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of special interest. An important reference, which explains the new nomenclature for Eph receptors and ligands.
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Unified nomenclature for Eph family receptors and their ligands, the ephrins. of special interest Cell. 90:1997;403-404 An important reference, which explains the new nomenclature for Eph receptors and ligands.
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(1997)
Cell
, vol.90
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2
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0030929986
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The Eph receptor family: Axonal guidance by contact repulsion
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Orioli D, Klein R. The Eph receptor family: axonal guidance by contact repulsion. Trends Genet. 13:1997;354-359.
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Trends Genet
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Orioli, D.1
Klein, R.2
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3
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0029041253
-
Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases
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Brambilla R, Schnapp A, Casagranda F, Labrador JP, Bergemann AD, Flanagan JG, Pasquale EB, Klein R. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J. 14:1995;3116-3126.
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Brambilla, R.1
Schnapp, A.2
Casagranda, F.3
Labrador, J.P.4
Bergemann, A.D.5
Flanagan, J.G.6
Pasquale, E.B.7
Klein, R.8
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4
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15844429889
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Eph receptors and ligands comprise two major specificity subclasses, and are reciprocally compartmentalized during embryogenesis
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of outstanding interest. A comprehensive study of receptor - ligand-binding interactions that establishes the idea of two major specificity subclasses, and demonstrates reciprocal domains of corresponding receptor and ephrin expression compartmentalising the embryo.
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Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, et al. Eph receptors and ligands comprise two major specificity subclasses, and are reciprocally compartmentalized during embryogenesis. of outstanding interest Neuron. 17:1996;9-19 A comprehensive study of receptor - ligand-binding interactions that establishes the idea of two major specificity subclasses, and demonstrates reciprocal domains of corresponding receptor and ephrin expression compartmentalising the embryo.
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(1996)
Neuron
, vol.17
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Gale, N.W.1
Holland, S.J.2
Valenzuela, D.M.3
Flenniken, A.4
Pan, L.5
Henkemeyer, M.6
Strebhardt, K.7
Hirai, H.8
Wilkinson, D.G.9
Pawson, T.10
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5
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0030874979
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The Eph family of receptros
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Pasquale EB. The Eph family of receptros. Curr Opin Cell Biol. 9:1997;608-615.
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Pasquale, E.B.1
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6
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0028110068
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Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
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Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science. 266:1994;816-819.
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Davis, S.1
Gale, N.W.2
Aldrich, T.H.3
Maisonpierre, P.C.4
Lhotak, V.5
Pawson, T.6
Goldfarb, M.7
Yancopoulos, G.D.8
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7
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0030962317
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The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling
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Labrador JP, Brambilla R, Klein R. The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling. EMBO J. 16:1997;3889-3897.
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EMBO J
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Labrador, J.P.1
Brambilla, R.2
Klein, R.3
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8
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0029867243
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A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn
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of special interest. The first analysis of Eph receptor in vitro autophosphorylation sites and demonstration of association of Src family kinases with Eph receptors.
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Ellis C, Kasmi F, Ganju P, Walls E, Panayotou G, Reith AD. A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. of special interest Oncogene. 17:1996;1727-1736 The first analysis of Eph receptor in vitro autophosphorylation sites and demonstration of association of Src family kinases with Eph receptors.
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(1996)
Oncogene
, vol.17
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Ellis, C.1
Kasmi, F.2
Ganju, P.3
Walls, E.4
Panayotou, G.5
Reith, A.D.6
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9
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0031001812
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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
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dok and Nck is dependent on conserved EphB2 juxtamembrane tyrosine residues.
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dok and Nck is dependent on conserved EphB2 juxtamembrane tyrosine residues.
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EMBO J
, vol.16
, pp. 3877-3888
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Holland, S.J.1
Gale, N.W.2
Gish, G.D.3
Roth, R.A.4
Songyang, Z.5
Cantley, L.C.6
Henkemeyer, M.7
Yancopoulos, G.D.8
Pawson, T.9
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10
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0028104680
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Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity
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Pandey A, Lazar DF, Saltiel AR, Dixit VM. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem. 269:1994;30154-30157.
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J Biol Chem
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Pandey, A.1
Lazar, D.F.2
Saltiel, A.R.3
Dixit, V.M.4
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11
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0029813872
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Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
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Stein E, Cerretti DP, Daniel TO. Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. J Biol Chem. 271:1996;23588-23593.
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Stein, E.1
Cerretti, D.P.2
Daniel, T.O.3
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12
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0031022602
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SAM as a protein interaction domain involved in developmental regulation
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Schultz J, Ponting CP, Hofmann K, Bork P. SAM as a protein interaction domain involved in developmental regulation. Protein Sci. 6:1997;249-253.
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Protein Sci
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Schultz, J.1
Ponting, C.P.2
Hofmann, K.3
Bork, P.4
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0030728938
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Ephrins and their receptors: A repulsive topic
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Gale NW, Yancopoulos GD. Ephrins and their receptors: a repulsive topic. Cell Tissue Res. 290:1997;227-241.
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Gale, N.W.1
Yancopoulos, G.D.2
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14
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0029851690
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Bidirectional signalling through the Eph-family receptor Nuk and its transmembrane ligands
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of outstanding interest. With [51], this paper illustrates that B class ephrins become tyrosine phosphorylated upon binding of the ectodomain of their cognate receptors, bio-chemically demonstrating the possibility of an intrinsic signalling function for transmembrane ephrins.
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Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T. Bidirectional signalling through the Eph-family receptor Nuk and its transmembrane ligands. of outstanding interest Nature. 383:1996;722-725 With [51], this paper illustrates that B class ephrins become tyrosine phosphorylated upon binding of the ectodomain of their cognate receptors, bio-chemically demonstrating the possibility of an intrinsic signalling function for transmembrane ephrins.
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(1996)
Nature
, vol.383
, pp. 722-725
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Holland, S.J.1
Gale, N.W.2
Mbamalu, G.3
Yancopoulos, G.D.4
Henkemeyer, M.5
Pawson, T.6
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15
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0029082312
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In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases
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Drescher U, Kremoser C, Handwerker C, Loschinger J, Noda M, Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
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(1995)
Cell
, vol.82
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Drescher, U.1
Kremoser, C.2
Handwerker, C.3
Loschinger, J.4
Noda, M.5
Bonhoeffer, F.6
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16
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0029086140
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Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map
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Cheng H-J, Nakamoto M, Bergemann AD, Flanagan JG. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell. 82:1995;371-381.
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Cell
, vol.82
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Cheng H-J1
Nakamoto, M.2
Bergemann, A.D.3
Flanagan, J.G.4
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17
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0030572695
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Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo
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of outstanding interest. An elegant study in which modification of axonal projections in the retinotectal topographic map are demonstrated in vivo upon ectopic expression of ephrin-A2 in the optic tectum.
-
Nakamoto M, Cheng H-J, Friedman GC, McLaughlin T, Hansen MJ, Yoo CH, O'Leary DDM, Flanagan JG. Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. of outstanding interest Cell. 86:1996;755-766 An elegant study in which modification of axonal projections in the retinotectal topographic map are demonstrated in vivo upon ectopic expression of ephrin-A2 in the optic tectum.
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(1996)
Cell
, vol.86
, pp. 755-766
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-
Nakamoto, M.1
Cheng H-J2
Friedman, G.C.3
McLaughlin, T.4
Hansen, M.J.5
Yoo, C.H.6
O'Leary, D.D.M.7
Flanagan, J.G.8
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18
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0030890656
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Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
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of special interest. The authors demonstrate that B class ephrins are able to mediate repulsive responses in axons, and, with [22], show that trunk neural crest cells are repelled by transmembrane ephrins.
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Wang HU, Anderson DJ. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. of special interest Neuron. 18:1997;383-396 The authors demonstrate that B class ephrins are able to mediate repulsive responses in axons, and, with [22], show that trunk neural crest cells are repelled by transmembrane ephrins.
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(1997)
Neuron
, vol.18
, pp. 383-396
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Wang, H.U.1
Anderson, D.J.2
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19
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0030957996
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Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors
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of special interest. The authors demonstrate aberrant migration of EphA8-expressing axons upon mutation of the EphA8 gene.
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Park S, Frisen J, Barbacid M. Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. of special interest EMBO J. 16:1996;3106-3114 The authors demonstrate aberrant migration of EphA8-expressing axons upon mutation of the EphA8 gene.
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(1996)
EMBO J
, vol.16
, pp. 3106-3114
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Park, S.1
Frisen, J.2
Barbacid, M.3
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20
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0344816258
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Nuk controls pathfinding of commissural axons in the mammalian central nervous system
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of outstanding interest. This is the first report of targetted mutation of an Eph receptor gene, demonstrating specific axonal guidance defects. In addition, the paper provides genetic evidence for transmembrane ephrin signalling.
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Henkemeyer M, Orioli D, Henderson JT, Saxton T, Roder J, Pawson T, Klein R. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. of outstanding interest Cell. 86:1996;35-46 This is the first report of targetted mutation of an Eph receptor gene, demonstrating specific axonal guidance defects. In addition, the paper provides genetic evidence for transmembrane ephrin signalling.
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(1996)
Cell
, vol.86
, pp. 35-46
-
-
Henkemeyer, M.1
Orioli, D.2
Henderson, J.T.3
Saxton, T.4
Roder, J.5
Pawson, T.6
Klein, R.7
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21
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0029858435
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Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation
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of special interest. This paper genetically demonstrates redundancy in Eph receptor function in vivo and also describes a non-neuronal phenotype of Eph receptor inactivation.
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Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. of special interest EMBO J. 15:1996;6035-6049 This paper genetically demonstrates redundancy in Eph receptor function in vivo and also describes a non-neuronal phenotype of Eph receptor inactivation.
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(1996)
EMBO J
, vol.15
, pp. 6035-6049
-
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Orioli, D.1
Henkemeyer, M.2
Lemke, G.3
Klein, R.4
Pawson, T.5
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22
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0031213749
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The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
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of outstanding interest. An elegant study that demonstrates the role of Eph receptors and transmembrane ephrins in neural crest stream migration by manipulation of Xenopus embryos.
-
Smith A, Robinson V, Patel K, Wilkinson DG. The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. of outstanding interest Curr Biol. 7:1997;561-570 An elegant study that demonstrates the role of Eph receptors and transmembrane ephrins in neural crest stream migration by manipulation of Xenopus embryos.
-
(1997)
Curr Biol
, vol.7
, pp. 561-570
-
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Smith, A.1
Robinson, V.2
Patel, K.3
Wilkinson, D.G.4
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23
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0031214537
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Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
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of special interest. The authors use in vitro and whole trunk explant assays to demonstrate a role for ephrin-B1 in segmental neural crest cell migration in chick embryos.
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Krull CE, Lansford R, Gale NW, Collazo A, Marcelle C, Yancopoulos GD, Fraser SE, Bronner-Fraser M. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. of special interest Curr Biol. 7:1997;571-580 The authors use in vitro and whole trunk explant assays to demonstrate a role for ephrin-B1 in segmental neural crest cell migration in chick embryos.
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(1997)
Curr Biol
, vol.7
, pp. 571-580
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-
Krull, C.E.1
Lansford, R.2
Gale, N.W.3
Collazo, A.4
Marcelle, C.5
Yancopoulos, G.D.6
Fraser, S.E.7
Bronner-Fraser, M.8
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24
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0028989595
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Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation
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Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F, et al. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14:1995;973-981.
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(1995)
Neuron
, vol.14
, pp. 973-981
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-
Winslow, J.W.1
Moran, P.2
Valverde, J.3
Shih, A.4
Yuan, J.Q.5
Wong, S.C.6
Tsai, S.P.7
Goddard, A.8
Henzel, W.J.9
Hefti, F.10
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25
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0031057545
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AL-1-induce growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeleton
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of special interest. Together with [26], this paper represents an initial characterisation of growth cone collapse initiated by A and B class ephrins.
-
Meima L, Kljavin IJ, Moran P, Shih A, Winslow JW, Caras IW. AL-1-induce growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeleton. of special interest Eur J Neurosci. 9:1997;177-188 Together with [26], this paper represents an initial characterisation of growth cone collapse initiated by A and B class ephrins.
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(1997)
Eur J Neurosci
, vol.9
, pp. 177-188
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-
Meima, L.1
Kljavin, I.J.2
Moran, P.3
Shih, A.4
Winslow, J.W.5
Caras, I.W.6
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26
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0030833727
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Lerk2 (Ephrin-B1) is a collapsing factor for a subset of growth cones and acts by a mechanism different from AL-1 (Ephrin-A5)
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of special interest. See annotation [25].
-
Meima L, Moran P, Matthews W, Caras IW. Lerk2 (Ephrin-B1) is a collapsing factor for a subset of growth cones and acts by a mechanism different from AL-1 (Ephrin-A5). of special interest Mol Cell Neurosci. 9:1997;314-328 See annotation [25].
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(1997)
Mol Cell Neurosci
, vol.9
, pp. 314-328
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Meima, L.1
Moran, P.2
Matthews, W.3
Caras, I.W.4
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27
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0030933742
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Tyrosine phosphorylation of L1 family adhesion molecules: Implication of the Eph kinase Cek5
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Zisch AH, Stallcup WB, Chong LD, Dahlin-Huppe K, Voshol J, Schachner M, Pasquale EB. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. J Neurosci Res. 47:1997;655-665.
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J Neurosci Res
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Zisch, A.H.1
Stallcup, W.B.2
Chong, L.D.3
Dahlin-Huppe, K.4
Voshol, J.5
Schachner, M.6
Pasquale, E.B.7
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28
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0030296507
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Disruption of cell adhesion in Xenopus embryos by Pagliaccio, an Eph-class receptor tyrosine kinase
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Winning RS, Scales JB, Sargent TG. Disruption of cell adhesion in Xenopus embryos by Pagliaccio, an Eph-class receptor tyrosine kinase. Dev Biol. 179:1996;309-319.
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Winning, R.S.1
Scales, J.B.2
Sargent, T.G.3
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29
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0029036501
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Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis
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Pandey A, Shao H, Marks RM, Polverini PJ, Dixit VM. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science. 268:1995;567-569.
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Pandey, A.1
Shao, H.2
Marks, R.M.3
Polverini, P.J.4
Dixit, V.M.5
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0027493163
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Biological and biochemical activities of a chimeric epidermal growth factor-elk receptor tyrosine kinase
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Lhotak V, Pawson T. Biological and biochemical activities of a chimeric epidermal growth factor-elk receptor tyrosine kinase. Mol Cell Biol. 13:1993;7071-7079.
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Lhotak, V.1
Pawson, T.2
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0028863477
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Making the connection: Cytoskeletal rearrangements during growth cone guidance
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Tanaka E, Sabry J. Making the connection: cytoskeletal rearrangements during growth cone guidance. Cell. 83:1995;171-176.
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Tanaka, E.1
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0028829750
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The rho's progress: A potential role during neuritogenesis for the rho family of GTPases
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Makay DJG, Nobes CD, Hall A. The rho's progress: a potential role during neuritogenesis for the rho family of GTPases. Trends Neurosci. 18:1995;497-501.
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Trends Neurosci
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Makay, D.J.G.1
Nobes, C.D.2
Hall, A.3
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Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
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Nobes CD, Hall A. Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81:1995;53-62.
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Nobes, C.D.1
Hall, A.2
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0026654125
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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
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Ridley A, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70:1992;401-410.
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Hall, A.5
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0026778133
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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
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Ridley A, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 70:1992;389-399.
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Ridley, A.1
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Rac1 mediates collapsin-1-induced growth cone collapse
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Jin Z, Strittmatter SM. Rac1 mediates collapsin-1-induced growth cone collapse. J Neurosci. 17:1997;6256-6263.
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Jin, Z.1
Strittmatter, S.M.2
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0028021308
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Inhibition of lysophosphatidate- And thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein rho
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Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S, Moolenaar WH. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein rho. J Cell Biol. 126:1994;801-810.
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Jalink, K.1
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Hengeveld, T.3
Morii, N.4
Narumiya, S.5
Moolenaar, W.H.6
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38
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0028086441
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Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
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Luo L, Liao J, Jan LY, Jan YN. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8:1994;1787-1802.
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Luo, L.1
Liao, J.2
Jan, L.Y.3
Jan, Y.N.4
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39
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0030866898
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Role of a new Rho family member in cell migration and axon guidance in C. elegans
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of outstanding interest. This paper provides genetic evidence for Rho function in axon guidance. The authors identify several mutations in a C. elegans Rho family member, mig-2, and demonstrate that a subset of these lead to misguided axon trajectories, showing that Rho family GTPases can couple guidance cues to process outgrowth.
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Zipkin ID, Kindt RM, Kenyon CJ. Role of a new Rho family member in cell migration and axon guidance in C. elegans. of outstanding interest Cell. 90:1997;883-894 This paper provides genetic evidence for Rho function in axon guidance. The authors identify several mutations in a C. elegans Rho family member, mig-2, and demonstrate that a subset of these lead to misguided axon trajectories, showing that Rho family GTPases can couple guidance cues to process outgrowth.
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(1997)
Cell
, vol.90
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Zipkin, I.D.1
Kindt, R.M.2
Kenyon, C.J.3
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40
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0029095073
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Characterisation of a novel src-like adapter protein that associates with the Eck receptor tyrosine kinase
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Pandey A, Duan H, Dixit VM. Characterisation of a novel src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem. 270:1995;19201-19204.
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J Biol Chem
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Pandey, A.1
Duan, H.2
Dixit, V.M.3
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41
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