The role of SRC-CAS interactions in cellular transformation: Ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation

Molecular Carcinogenesis

Volumn 26, Issue 1, 1999, Pages 20-31

  Burnham, Mary Rose ^a   Harte, Mary T ^a,b   Bouton, Amy H ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Crk associated substrate; Phosphotyrosine; Src; Src substrates; Transformation

Indexed keywords

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL TRANSFORMATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ACTINS; ANIMALS; CELL ADHESION; CELL TRANSFORMATION, NEOPLASTIC; ONCOGENE PROTEIN PP60(V-SRC); PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RATS; SRC-FAMILY KINASES; TYROSINE; UBIQUITIN-PROTEIN LIGASES;

EID: 0032850790     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199909)26:1<20::AID-MC3>3.0.CO;2-M     Document Type: Article

References (63)

1. src with two tyrosine-phosphorylated cellular proteins. Mol Cell Biol 1989;9: 3951-3958.
2. src direct stable association with tyrosine phosphorylated proteins p 130 and p110. EMBO J 1991;10:1689-1698.
3. Sakai R, Iwamatsu A, Hirano N, et al. A novel signaling molecule, p 130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J 1994;13:3748-3756.
4. Sakai R, Iwamatsu A, Hirano N, et al. Characterization, partial purification, and peptide sequencing of p130, the main phosphoprotein associated with v-Crk oncoprotein. J Biol Chem 1994;269:32740-32746.
5. Zachary I, Sinnett-Smith J, Rozengurt E. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. J Biol Chem 1992; 267:19031-19034.
6. FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells. J Biol Chem 1994;269:9345-9351.
7. CAS, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J Biol Chem 1995;270: 15398-15402.
8. Petch LA, Buckholt SM, Bouton AH, Parsons JT, Burridge K. Adhesion-induced tyrosine phosphorylation 7f the p130 src substrate. J Cell Sci 1995;108:1371-1379.
9. CAS and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J Biol Chem 1995;270: 22259-22262.
10. CAS-binding proteins and their role in cellular transformation. Oncogene 1996; 12:2467-2472.
11. CAS. Biochem Biophys Res Comm 1996;222:338-343.
12. CAS, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J Biol Chem 1996;271:13649-13655.
13. CAS in PC-12 cells. J Biol Chem 1996;271:7375-7380.
14. CAS signaling complex formation upon integrinmediated cell adhesion: A role for Src family kinases. Mol Cell Biol 1995;16:2606-2613.
15. CAS as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions. EMBO J 1997;16: 2730-2744.
16. CAS and FAK, and the associated accumulation of these proteins in peripheral focal adhesions. EMBO J 1997;16:2307-2318.
17. CAS in differentiating neuroblastoma cells. J Biol Chem 1998;273: 2336-2343.
18. Klemke RL, Leng J, Molander R, Brooks PC, Vuori K, Cheresh DA. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. J Cell Biol 1998;140:961-972.
19. CAS is involved in actin organization in osteoclasts. J Biol Chem 1998;273:11144-11149.
20. CAS. Proc Natl Acad Sci USA 1995;92:10678-10682.
21. CAS. J Biol Chem 1997;272:228-232.
22. CAS to SH2 and SH3 domains of Src kinase. J Biol Chem 1996;271: 8959-8965.
23. gag-crk, to a broad range of phosphotyrosine-containing proteins. Science 1990;248: 1537-1539.
24. Matsuda M, Mayer BJ, Hanafusa H. Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. Mol Cell Biol 1991;11:1607-1613.
25. Mayer BJ, Hanafusa H. Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. Proc Natl Acad Sci USA 1990; 87:2638-2642.
26. CAS, and Nck adaptor proteins. Mol Cell Biol 1997;17:1702-1713.
27. CAS as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol Cell Biol 1996;16:6408-6418.
28. CAS. J Biol Chem 1996;271: 31290-31295.
29. CAS. Nat Genet 1998;19:361-365.
30. CAS. Mol Cell Biol 1995;15: 6513-6525.
31. src function. J Virol 1988;62: 1898-1906.
32. src. Mol Cell Biol 1990; 10:1254-1258.
33. CAS using a panel of monoclonal antibodies. Hybridoma 1997;16:403-411.
34. Kanner SB, Reynolds AB, Vines RR, Parsons JT. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci USA 1990;87:3328-3332.
35. src substrate. Mol Cell Biol 1993;13:7892-7900.
36. Olson MF, Pasteris NG, Gorski JL, Hall A. Faciogenital dysplsia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr Biol 1996;6: 1628-1633.
37. Jove R, Hanafusa H. Cell transformation by the viral src oncogene. Ann Rev Cell Biol 1987;3:31-56.
38. Parsons JT, Weber MJ. Genetics of src: Structure and functional organization of a protein tyrosine kinase. Curr Top Microbiol Immunol 1989;147:79-95.
39. Guappone AC, Flynn DC. The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src. Mol Cell Biochem 1997;175:243-252.
40. Guappone AC, Weimer T, Flynn DC. Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. Mol Carcinog 1998;22:110-119.
41. Boschek CB, Jockusch BM, Friis RR, Back R, Grundmann E, Bauer H. Early changes in the distribution and organization of microfilament proteins during cell transformation. Cell 1981;24:175-184.
42. Tarone G, Cirillo D, Giancotti FG, Comoglio PM, Marchisio PC. Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes. Exp Cell Res 1985;159:141-157.
43. Marchisio PC, Cirillo D, Teti A, Zambonin-Zallone A, Tarone G. Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions. Exp Cell Res 1987;169: 202-214.
44. Xu W, Harrison SC, Eck MJ. Three-dimensional structure of the tyrosine kinase c-Src. Nature 1997;385:595-602.
45. c-src. Cell 1987;49:75-82.
46. Reynolds AB, Vila J, Lansing TJ, Potts WM, Weber MJ, Parsons JT. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J 1987;6:2359-2364.
47. Cobb BS, Payne DM, Reynolds AB, Parsons JT. Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527). Mol Cell Biol 1991;11:5832-5838.
48. Cobb BS, Parsons JT. Regulation of the cellular src protein tyrosine kinase: Interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527. Oncogene 1993;8:2897-2903.
49. src. Mol Cell Biol 1994;14:1680-1688.
50. CAS-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae. Mol Cell Biol 1996;16:3327-3337.
51. Brugge JS. Casting light on focal adhesions. Nat Genet 1998;19:309-311.
52. Cas as a mediator of focal adhesion kinase-promoted cell migration. J Cell Biol 1998;140:211-221.
53. cas to focal adhesions. Mol Cell Biol 1997;17:3884-3897.
54. FAK. FEBS Lett 1998;432:197-201.
55. Cas to the guanine nucleotide exchange factor C3G. J Biol Chem 1998;273:25673-25679.
56. Ichiba T, Kuraishi Y, Sakai O, et al. Enhancement of guaninenucleotide exchange activity of C3G for Rap 1 by the expression of Crk, CrkL, and Grb2. J Biol Chem 1997; 272:22215-22220.
57. Bos JL. All in the family? New insights and questions regarding interconnectivity of Ras, Rap 1 and RaI. EMBO J 1998;17:6776-6782.
58. Aftab DT, Kwan J, Martin GS. Ras-independent transformation by v-Src. Proc Natl Acad Sci USA 1997;94: 3028-3033.
59. Oldham SM, Cox AD, Reynolds ER, Sizemore NS, Coffey JR, Der CJ. Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade Oncogene 1998;16:2565-2573.
60. Smith MR, DeGudicibus SJ, Stacey DW. Requirement for c-ras proteins during viral oncogene transformation. Nature 1986;320:540-543.
61. Stacey DW, Roudebush M, Day R, Mosser SD, Gibbs JB. Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. Oncogene 1991;6:2297-2304.
62. DeClue JE, Zhang K, Redford P, Vass WC, Lowy DR. Suppression of src transformation by overexpression of fulllength GTPase-activating protein (GAP) or of the GAP C terminus. Mol Cell Biol 1991;11:2819-2825.
63. Nori M, Vogel US, Gibbs JB, Weber MJ. Inhibition of v-src-induced transformation by a GTPase-activating protein. Mol Cell Biol 1991;11:2812-2818.