Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats

Human Gene Therapy

Volumn 10, Issue 9, 1999, Pages 1545-1551

  Engelmann, Carsten ^a,d   Panis, Yves ^d,e   Bolard, Jacques ^b   Diquet, Bertrand ^a,c   Fabre, Monique ^f   Nagy, Helena ^a,d   Soubrane, Olivier ^d   Houssin, Didier ^d   Klatzmann, David ^a,b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c Serv Pharm Pharmacies P

^d Lab de Recherche Chirurgicale Hôpital Cochin ^*  (France)

^e HÔPITAL LARIBOISIÈRE   (France)

^f BICÊTRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; LIPOSOME; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; ENCAPSULATION; GENE TARGETING; GENE THERAPY; HERPES SIMPLEX VIRUS 1; LIVER TUMOR; NONHUMAN; RAT; SUICIDE GENE; TISSUE DISTRIBUTION; TUMOR VOLUME;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 1;

EID: 0033542386     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017879     Document Type: Article

References (36)

1. ALLEN, D. M., and SMUCKLER, E. (1985). Liver pathology accompanying chronic liposome administration in mouse. Res. Commun. Chem. Pathol. Pharmacol. 50, 281.
2. ANONYMUS (1997). List of approved gene therapy trials. Hum. Gene Ther. 8, 2031-2038.
3. BAKKER-WOUDENBERG, I., LOKERSE, A., and KATE, M. (1990). Increased efficacy of ganciclovir and foscarnet inhibition of cytomegalovirus replication in vitro by encapsulation in liposomes. Scand. J. Infect. Dis. 74(Suppl.), 54-57.
4. BOULIEU, R., BLEYZAC, N., and FERRY, S. (1991). High performance liquid chromatographic determination of ganciclovir in plasma. J. Chromatogr. 567(2), 481-484.
5. CARMICHAEL, J., DE GRAFF, W. G., GAZDAR, A. F., MINNA, J. D., and MITCHELL, J. B. (1987). Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity. Cancer Res. 47(4), 943-946.
6. CARUSO, M., PANIS, Y., GAGANDEEP, S., HOUSSIN, D., SALZMANN, J. L., and KLATZMANN, D. (1993). Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. U.S.A. 90, 7024-7028.
7. ELSHAMI, A., COOK, J. W., AMIN, K., CHOI, H., PARK, J. Y., COONROD, L., SUN, J., MOLNAR-KIMBER, K., WILSON, J., KAISER, L., and ALBELDA, S. (1997). The effect of promoter strength in adenoviral vectors containing herpes simplex virus thymidine kinase on cancer gene therapy in vitro and in vivo. Cancer Gene Ther. 4(4), 213-221.
8. FAULDS, D., and HEEL, C. (1990). Ganciclovir. Drugs 39(4), 597-638.
9. FREEMAN, S. M., RAMESH, R., and MARROGHI, A. J. (1997). Immune system in suicide gene therapy. Lancet 349, 2-3.
10. GABIZON, A., CHISIN, R., AMSELM, S., DRUCKMANN, S., COHEN, R., GOREN, D., FROMER, I., PERETZ, T., SULKES, A., and BARENHOLTZ, Y. (1991). Pharmacokinetic and imaging studies in patients receiving a formulation of liposome associated Adriamycin. Br. J. Cancer 64, 1125-1132.
11. HAFENRICHTER, D. G., WU, X., RETTINGER, S. D., KENNEDY, S. C., FUGE, M. W., and PONDER, K. P. (1994). Quantitative evaluation of liver specific promoters from retroviral vectors after in vivo transduction of hepatocytes. Blood 84(10), 3394-3404.
12. HARAN, G., COHEN, R., BAR, L., and BARENHOLZ, Y. (1993). Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipatic weak bases. Biochim. Biophys. Acta 1151, 201-215.
13. HARASHIMA, H., SAKATA, K., and KIWADA, H. (1993). Distinction between the depletion of opsonins and the saturation of uptake in the dose-dependent hepatic uptake of liposomes. Pharm. Res. 10, 606-610.
14. HARASHIMA, H., SAKATA, K., FUNATO, K., and KIWADA, H. (1994). Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes. Pharm. Res. 11(3), 402-406.
15. HENDERSON, G., HU, Z., YANG, Y., PEREZ, T., DEVI, B., FROSTO, T. A., and SCHENKER, S. (1993). Ganciclovir transfer by human placenta and its effects on rat fetal cells. Am. J. Med. Sci. 306(3), 151-156.
16. JANKNEGT, R., DE MARIE, S., BAKKER-WOUDENBERG, A. J. M., and CROMMELIN, D. J. A. (1992). Liposomal and lipid formulations of amphotericin B. Clin. Pharmacokinet. 23, 279-281.
17. JOHANSEN, M. J., NEWMAN, R. A., and MADDEN, T. (1997). The use of microdialysis in pharmacokinetics and pharmacodynamics. Pharmacotherapy 17(3), 464-481.
18. KIANMANESH, A. R., PERRIN, H., PANIS, Y., FABRE, M., NAGY, H. J., HOUSSIN, D., and KLATZMANN, D. (1997). A "distant" bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distinct transduced tumor. Hum. Gene Ther. 8, 1807-1814.
19. KONNO, H., MARUO, H., MATSUDA, I., NAKAMURA, S., and BABA, S. (1995). Intra-arterial liposomal Adriamycin for metastatic adenocarcinoma of the liver. Eur. Surg. Res. 27, 301-306.
20. LE BOURLAIS, C., CHEVANN, F., ROPERT, P., BRETAGNE, G., ACAR, L., ZIA, H., SASO, P. A., NEEDHAM, T., and LEVERGE, R. (1996). Release kinetics of liposome-encapsulated ganciclovir after intravitreal injection in rabbits. J. Microencapsulation 13, 473-480.
21. LITZINGER, D., BUITING, A. M., ROOIJEN, N., and HUANG, L. (1994). Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylen-glycol)-containing liposomes. Biochim. Biophys. Acta 1190, 99-107.
22. MAHONY, W., DOMIN, B., and ZIMMERMANN, T. (1991). Ganciclovir permeation of the human erythrocyte membrane. Biochem. Pharmacol. 41, 263-271.
23. MAYER, D., BALLY, M. B., HOPE, M. J., and CULLIS, P. (1985). Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential. Biochim. Biophys. Acta 816, 294-302.
24. MAYER, D., BALLY, B., and CULLIS, P. (1986). Uptake of Adriamycin into large unillamellar vesicles in response to a pH gradient. Biochim. Biophys. Acta 857, 123-126.
25. MAYER, L. D., HOPE, M. J., CULLIS, P. R., and JANOFF, A. S. (1985). Solute distributions and trapping efficiencies observed in freeze thawed multilamellar vesicles. Biochim. Biophys. Acta 817, 193-196.
26. MOOLTEN, F. L. (1986). Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46, 5276-5281.
27. NAGY, H., PANIS, Y., FABRE, M., PERRIN, H., KLATZMANN, D., and HOUSSIN, D. (1998). Are hepatomas a good target for gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene. Surgery 123, 19-24.
28. NEW, R. C. (1997). Liposomes, 4th Ed. (Oxford University Press, Oxford) pp. 131-133.
29. NICHOLAS, A. R., and JONES, M. N. (1986). The absorption of phospholipid vesicles by perfused rat liver depends on vesicle surface charge. Biochim. Biophys. Acta 860, 600-607.
30. PANIS, Y., CARUSO, M., and HOUSSIN, D. (1992). Traitement de tumeurs hépatiques expérimentales par transfert de gène suicide in vivo chez le rat. C.R. Acad. Sci. (Paris) 315, 541.
31. ROUGIER, P., DUCREUX, M., ELIAS, D., and LASSER, P. (1996). Hepatic metastases of colorectal cancers: Intra-arterial chemotherapy. Value and indications. Presse Med. 25, 1683-1688.
32. SHIMIZU, H., KOICHIRO, K., UYAMA. I., SHIBATA, S., TAGAWA, T., NAGAIKE, K., YASUNDA, T., KITAJIMA, M., and TADAKUMA, T. (1996). Improvement of pharmacokinetics and antitumor activity against human hepatoma cell line by using Adriamycin-entrapped stealth liposomes. J. Surg. Oncol. 62, 186-193.
33. 4. Anal. Biochem. 104, 10.
34. SZOKA, F., and PAPAHADJOPOULOS, D. (1978). Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc. Natl. Acad. Sci. U.S.A. 75, 4194-4198.
35. UPTON, R. A. (1975). Simple and reliable method for serial sampling of blood from rat. J. Pharm. Sci. 64, 112-114.
36. YACHI, K., SUZUKI, N., TANAKA, N., OKADA, K., MITSUI, I., KAWATO, Y., KOMAGATA, Y., KOMIYAMA, K., and KIKUCHI, H. (1996). The effect of Adriamycin against a liver metastatic model by encapsulation in liposomes. Biopharm. Drug Dispos. 17, 699-715.