Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma

Cancer Research

Volumn 56, Issue 6, 1996, Pages 1315-1323

  Hoganson, Diana K ^a   Batra, Raj K ^a   Olsen, John C ^a   Boucher, Richard C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; CYTOSINE DEAMINASE; DEOXYCYTIDINE KINASE; THYMIDINE KINASE; VIRUS VECTOR;

ARTICLE; CANCER GROWTH; CELL GROWTH; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GROWTH INHIBITION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ANTIMETABOLITES; CELL DIVISION; CYTOMEGALOVIRUS; CYTOSINE DEAMINASE; DEOXYCYTIDINE KINASE; ENZYME INDUCTION; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNOTOXINS; LUNG NEOPLASMS; NUCLEOSIDE DEAMINASES; PHOSPHORYLATION; PLEURAL NEOPLASMS; PRODRUGS; SIMPLEXVIRUS; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0029923506     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Beckett, W. S. Epidemiology and etiology of lung cancer. Clin. Chest Med., 14: 1-15, 1993.
2. Pass, H. I. Treatment of metastatic pleural and pericardial effusions. In V. T DeVita (ed ), Cancer Principles and Practice of Oncology, pp 2246-2255 Philadelphia, PA. J B Lippincott Co., 1989
3. Sahn, S. A. Pleural effusion in lung cancer. Clin. Chest Med., 14: 189-200, 1993.
4. Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res., 46: 5276-5281, 1986.
5. Moolten, F L., Wells, J. M., Heyman, R. A., and Evans, R. M. Lymphoma regression induced by ganciclovir in mice bearing a herpes thymidine kinase transgene. Hum. Gene Ther., 1. 125-134, 1990.
6. Smythe, W. R., Hwang, H. C., Amin, K. M., Eck, S. L., Davidson, B. L., Wilson, J. M , Kaiser, L R., and Albelda, S M Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms. an effective in vitro drug sensitization system. Cancer Res., 54: 2055-2059, 1994.
7. Ram, Z., Walbridge, S , Shawker, T., Culver, K. W., Blaese, R M., and Oldfield, E H. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J. Neurosurg., 81: 256-260, 1994.
8. Mullen, C. A., Kilstrup, M , and Blaese, R. M. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine a negative selection system. Proc. Natl. Acad. Sci. USA, 89: 33-37, 1992.
9. Huber, B. E., Austin, E A., Richards, C. A., Davis, S. T , and Good, S. S. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. USA, 91. 8302-8306, 1994.
10. Chottiner, E. G., Shewach, D S., Datta, N. S , Ashcraft, E., Gribbin, D , Ginsburg, D , Fox, I. H., and Mitchell, B S Cloning and expression of human deoxycytidine kinase cDNA Proc. Natl. Acad. Sci. USA, 88: 1531-1535, 1991.
11. Mancini, W R The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3′-amino-2′,3′-dideoxycytidine and cytosine arabinoside. Cancer Chemother. Pharmacol , 30 139-144, 1992
12. Bi, W. L., Parysek, L. M , Warnick, R., and Stambrook, P. J. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther., 4: 725-731, 1993.
13. Kufe, D W., and Major, P. P. Studies on the mechanism of action of cytosine arabinoside. Med. Pediatr. Oncol., 1 (Suppl.): 49-67, 1982.
14. Ram, Z., Culver, K W., Walbridge, S., Blaese, R. M., and Oldfield, E. H. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res., 53: 83-88, 1993.
15. Miller, D. G., Adam, M. A., and Miller, A D Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol., 10: 4239-4242, 1990
16. Miller, A. D , and Rosman, G. J Improved retroviral vectors for gene transfer and expression Biotechniques, 7: 980-990, 1989.
17. Adam, M. A., Ramesh, N., Miller, A. D., and Osborne, W. R Internal initiation of translation in retroviral vectors carrying picornavirus 5′ nontranslated regions. J. Virol., 65: 4985-4990, 1991.
18. Wagner, M J , Sharp, J. A , and Summers, W C Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA, 78: 1441-1445, 1981.
19. Miller, A. D., and Buttimore, C. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production Mol Cell. Biol., 6: 2895-2902, 1986
20. Olsen, J C., Johnson, L G , Stutts, M J., Sarkadi, B , Yankaskas, J. R., Swanstrom, R., and Boucher, R. C Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer Hum Gene Ther., 3 253-266, 1992.
21. Olsen, J. C , and Sechelski, J. Use of sodium butyrate to enhance production of retroviral vectors expressing CFTR cDNA Hum. Gene Ther., 6: 1195-1202, 1995.
22. Arner, E. S J , Spasoloulotskaja, T , and Eriksson, S. Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues Biochem. Biophys. Res Commun., 188: 712-718, 1992.
23. Richards, C A , Austin, E A , and Huber, B E Transcriptional regulatory sequences of carcineoembryonic antigen: identification and use of cytosine deaminase for tumor-specific gene therapy Hum Gene Ther., 6: 881-893, 1995.
24. Sugimoto, Y , Aksentijevich, I , Gottesman, M M , and Pastan, I. Efficient expression of drug-selectable genes in retroviral vectors under control on an internal ribosome entry site BioTechnology, 12 694-698, 1994
25. Freeman, S M., Abboud, C N , Whartenby, K. A., Packman, C. H., Koeplin, D. S , Moolten, F. L , and Abraham, G. N The "bystander effect." Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53: 5274-5283, 1993
26. Culver, K W., Ram, Z , Wallbridge, S , Ishii, H , Oldfield, E. H., and Blaese, R. M In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors Science (Washington DC), 256: 1550-1552, 1992.
27. Tang, D. C., and Taylor, M W. Memory of butyrate induction by the Moloney murine sarcoma virus enhancer-promoter element. Biochem. Biophys. Res. Commun , 189: 141-147, 1991.
28. Yeivin, A., Tang, D. C., and Taylor, M. W. Sodium butyrate selectively induces transcription of promoters adjacent to the MoMSV viral enhancer. Gene (Amst.), 116: 159-164, 1992.
29. Palmer, T. D., Rosman, G. J , Osborne, W. R. A., and Miller A. D Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc. Natl. Acad Sci. USA, 88: 1330-1334, 1991.
30. Boshart, M., Weber, F., Jahn, G , Dorsch-Hasler, K., Fleckenstein, B , and Schaffner, W. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell, 41 521-530, 1985.
31. Scharfmann, R , Azelrod, J. H., and Verma, I. M. Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc. Natl. Acad. Sci. USA, 88: 4626-4630, 1991
32. Mikulits, W , and Mullner, E. W. Post-transcriptional repression of thymidine kinase expression during cell cycle and growth stimulation. FEBS Lett., 345: 172-176, 1994.
33. Kawasaki, H., Carrera, C. J , Piro, L. D., Saven, A., Kipps, T J , and Carson, D. A Relationship of deoxycytidine kinase and cytoplasmic 5′-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine. Blood, 81: 597-601, 1993
34. Preisler, H. D., Rustum, Y., and Priore, R. L. Relationship between leukemic cell retention of cytosine arabinoside triphosphate and the duration of remission in patients with acute nonlymphocytic leukemia. Eur. J. Cancer & Clin. Oncol., 21: 23-30, 1985.
35. Wu, J. K., Cano, W. G., Meylaerts, S. A. G , Qi, P., Vrionis, F , and Cherington, V Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery, 35: 1094-1103, 1994.
36. Mullen, C. A., Coale, M. M., Lowe, R., and Blaese, R. M. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor Cancer Res., 54: 1503-1506, 1994.
37. Moolten, F. L., and Wells, J. M. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J. Natl. Cancer Inst , 82: 297-300, 1990.