Peptide inhibitors expressed in vivo

Current Opinion in Chemical Biology

Volumn 5, Issue 1, 2001, Pages 74-77

  Kamb, Alexander ^a   Caponigro, Giordano ^a  

^a Arcaris Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC SCREENING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN ISOLATION; REVIEW;

ANIMALS; GENE TRANSFER TECHNIQUES; HUMANS; PEPTIDE LIBRARY; PEPTIDES; PROTEINS;

ESCHERICHIA COLI;

EID: 0035252859     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00160-5     Document Type: Review

References (26)

1. Drug target validation: Lethal infection blocked by inducible peptide
2. Isolation of peptide aptamers that inhibit intracellular process
3. 'Mutagensis' by peptide aptamers identifies genetic network members and pathway connections
4. Genetic selection of peptide inhibitors of biological pathways
5. Transdominant genetic analysis of a growth control pathway
6. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
7. Targeting cyclin-dependent kinases in Drosophila with peptide aptamers
8. An artificial cell-cycle inhibitor isolated from a combinatorial library
9. Retroviral delivery of peptide modulators of cellular functions
10. Functional inactivation of genes by dominant negative mutations
11. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA
12. Identification of p53 genetic suppressor elements which confer resistance to cisplatin
13. Reversible transdominant inhibition of a metabolic pathway. In vivo evidence of interaction between two sequential tricarboxylic acid cycle enzymes in yeast
14. ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
15. Design of a synthetic Mdm2-binding mini protein that activates response in vivo
16. Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E
17. Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1
18. A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: Affinity, stoichiometry, and thermodynamics
19. Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
20. A novel genetic system to detect protein-protein interactions
21. Protein-peptide interactions analyzed with the yeast two-hybrid system
22. Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2
23. Finding prospective partners in the library: The two-hybrid system and phage display find a match
24. Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity
25. Gene therapy: Beyond 2000
26. Therapeutic peptides and peptidomimetics