T-cell signaling - Effect of age

Experimental Gerontology

Volumn 37, Issue 1, 2001, Pages 33-39

  Chakravarti, Bulbul ^a  

^a ROCHESTER INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aging; T cell signaling

Indexed keywords

ADAPTOR PROTEIN; CD28 ANTIGEN; CYTOKINE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

AGING; ANTIGEN EXPRESSION; CELL CYCLE PHASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME SUBSTRATE; HUMAN; IMMUNOLOGY; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RODENT; SHORT SURVEY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

AGING; ANIMALS; HUMANS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

RODENTIA;

EID: 0035216026     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00175-9     Document Type: Short Survey

References (32)

1. Aging and T-cell mediated immunity
2. Effect of age on mitogen induced protein tyrosine phosphorylation in human T-cell and its subsets: Down-regulation of tyrosine phosphorylation of ZAP-70
3. Costimulatory mechanisms in the elderly
4. Age-related impairment of p56lck and ZAP-70 activities in human T lymphocytes activated through the TCR/CD3 complex
5. Increased ZAP-70 association with CD3 zeta in CD4 T cells from old mice
6. Single-cell analyses reveal two defects in peptide-specific activation of T cells from aged mice
7. Rapid tyrosine phosphorylation of Grb2 and Shc in T cells exposed to anti-CD3, anti-CD4, and anti-CD45 stimuli: Differential effects of aging
8. Age-related changes of signal transduction in T cells
9. Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: Effect of age
10. Age-sensitive and insensitive pathways leading to JNK activation mouse CD4(+) T-cells
11. Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes
12. Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging
13. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR complex and costimulatory signals
14. Early activation defects in T lymphocytes from aged mice
15. Adapter proteins in lymphocyte antigen-receptor signaling
16. Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells
17. Influence of aging and caloric restriction on activation of Ras/MAPK, calcineurin, and CaMK-IV activities in rat T cells
18. Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats
19. The JNK and p38 MAP kinase signaling pathways in T cell-mediated immune response
20. Resistance to apoptosis in human CD8 + T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation
21. Age-dependent alterations in the assembly of signal transudation complexes at the site of T cell/PAC interaction
22. Decreased association of p56lck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging
23. Current status and perspectives of proteomics in aging research
24. Impairment of signal transduction in T cells from old mice
25. Modulation of CD28 expession: Distinct regulatory pathways during activation and replicative senescence
26. Functional disruption of the CD28 gene transcriptional initiator in senescent T cells
27. Functional properties of CD4 + CD28 - T cells in the aging immune system
28. Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex
29. Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through T cell receptor (TCR)/CD3 complex
30. Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans
31. Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylation of zeta-chains and p59fyn/p56lck in human T cells
32. Cluster formation by protein kinase C theta during murine T cell activation: Effect of age