Conversion of Threonine 757 to Valine Enhances Stat5a Transactivation Potential

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10485-10491

  Gowri, P Mangala ^a   Ganguly, Tanmoy C ^a,c   Cao, Jingsong ^a   Devalaraja, Madhav N ^a,d   Groner, Bernd ^b   Vore, Mary ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIMERS; DNA; GENES; HORMONES; PROTEINS;

BINDING ABILITY;

BIOCHEMISTRY;

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ASPARTIC ACID; CYTOKINE; DNA; GROWTH HORMONE; LIGAND; LUCIFERASE; PROLACTIN; PROTEIN SERINE THREONINE KINASE; STAT5 PROTEIN; STAT5A PROTEIN; THREONINE; TYROSINE; UNCLASSIFIED DRUG; VALINE; BETA GALACTOSIDASE; DNA BINDING PROTEIN; MILK PROTEIN; STAT5A PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; CELL LINE; CELL NUCLEUS; CHEMISTRY; DOSE RESPONSE; GENETIC TRANSFECTION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PLASMID; PROTEIN TERTIARY STRUCTURE; TIME; WESTERN BLOTTING;

ASPARTIC ACID; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; DNA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; LUCIFERASES; MILK PROTEINS; PHOSPHORYLATION; PLASMIDS; PROLACTIN; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; THREONINE; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; VALINE;

EID: 0035971162     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007156200     Document Type: Article

References (39)

1. Ihle, J. N. (1996) Cell 4, 331-334
2. Schindler, C., and Darnell, J. E., Jr. (1995) Annu. Rev. Biochem. 64, 621-651
3. Darnell, J. E. (1997) Science 277, 1630-1635
4. Briscoe, J., Kohlhuber, F., and Muller, M. (1996) Trends Cell Biol. 6, 336-340
5. Wen, Z., Zhong, A., and Darnell, J. E., Jr. (1995) Cell 82, 241-250
6. Morrigl, R., Gouilleux-Gruart, V., Jahne, R., Berchtold, S., Gartmann, C., Liu, X., Hennighausen, L., Sotriropoulos, A., Groner, B., and Gouilleux, F. (1996) Mol. Cell. Biol. 16, 5691-5700
7. Li, S., and Rosen, J. M. (1995) Mol. Cell. Biol. 15, 2063-2070
8. Burdon, T. G., Maitland, K. A., Clark, A. J., Wallace, R., and Watson, C. J. (1994) Mol. Endocrinol. 8, 1528-1536
9. Groner, B., and Gouilleux, F. (1995) Curr. Opin. Gen. Dev. 5, 587-594
10. Waxman, D. J., Ram, P. A., Park, S.-H., and Choi, H. K. (1995) J. Biol. Chem. 270, 13262-13270
11. Ram, P. A., Park, S.-H., Choi, H. K., and Waxman, D. J. (1996) J. Biol. Chem. 271, 5929-5940
12. Galsgaard, E. D., Gouilleux, F., Groner, B., Serup, P., Neilson, J. H., and Billestrup, N. (1996) Mol. Endocrinol. 10, 652-660
13. Kordula, T., Ripperger, J., Morella, K., Travis, J., and Baumann, H. (1996) J. Biol. Chem. 271, 6752-6757
14. Verdier, F., Rabionet, R., Gouilleux, F., Beisenherz-Huss, C., Varlet, P., Muller, O., Mayeux, P., Lacombe, C., Gisselbrecht, S., and Chretien, S. (1998) Mol. Cell. Biol. 18, 5852-5860
15. Ganguly, T. C., O'Brien, M. L., Karpen, S. J., Hyde, J. F., Suchy, F. J., and Vore, M. (1997) J. Clin. Invest. 99, 2906-2914
16. Gebert, C., Park, S.-H., and Waxman, D. J. (1997) Mol. Endocrinol. 11, 400-414
17. Azam, M., Erdjument-Bromage, H., Kreider, B. L., Xia, M., Quelle, F., Basu, R., Saris, C., Tempst, P., Ihle, J. N., and Schindler, C. (1995) EMBO J. 14, 1402-1411
18. Kazasky, A. V., Raught, B., Lindsey, M., Wang, Y., and Rosen, J. M. (1995) Mol Endocrinol 9, 1598-1609
19. Liu, X., Robinson, G. W., Gouilleux, F., Groner, B., and Hennighausen, L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 8831-8835
20. Rippberger, J. A., Fritz, S., Richter, K., Hocke, G. M., Lottspeich, F., and Fey, G. H. (1995) J. Biol. Chem. 270, 29998-30006
21. Beuvink, I., Hess, D., Flotow, H., Jofsteenge, J., Groner, B., and Hynes, N. E. (2000) J. Biol. Chem. 275, 10247-10255
22. Marini, F., Naeem, A., and Lapeyre, J. N. (1993) Nucleic Acids Res. 9, 2277-2278
23. O'Brien, M., Rangwala, S. M., Henry, K. W., Weiberger, C., Crick, D. C., Waechter, C. J., Feller, D. R., and Noonan, D. J. (1996) Carcinogenesis 17, 185-190
24. Morrigl, R., Berchtold, S., Friedrich, K., Standke, G. J. R., Kammer, W., Heim, M., Stockin, E., Gouilleux, F., and Groner, B. (1997) Mol. Cell. Biol. 17, 3663-3678
25. Lowry, O. H., Rosenbrough, N. J., Farr, A. J., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
26. Gouilleux, F. H., Wakao, M., Mundt, M., and Groner, B. (1994) EMBO J. 13, 4361-4369
27. Engh, R. A., Girod, A., Kinzel, V., Huber, R., and Bossemeyer, D. (1996) J. Biol. Chem. 271, 26157-26164
28. Xu, X., Sun, Y.-L., and Hoey, T. (1996) Science 273, 794-797
29. Deleted in proof.
30. Wang, D., Stravopodis, D., Teglund, S., Kitazawa, J., and Ihle, J. N. (1996) Mol. Cell. Biol. 16, 6141-6148
31. Sims, S. H., Cha, Y., Romine, M. F., Gao, P.-Q., Gottlieb, K., and Deisseroth, A. B. (1993) Mol. Cell. Biol. 13, 690-702
32. Ram, P. A., and Waxman, D. J. (1997) J. Biol. Chem. 272, 17694-17702
33. Wartmann, M., Cella, N., Hofer, P., Groner, B., Liu, X., Henighausen, L., Hynes, N. F. (1996) J. Biol. Chem. 271, 31863-31868
34. Kirken, R. A., Malabarba, M. G., Xu, J., Liu, X., Farrar, W. L., Hennighausen, L., Larner, A. C., Grimleey, P. M., and Rui, H. (1997) J. Biol. Chem. 272, 14098-14103
35. Kirken, R. A., Malabarba, M. G., Xu, J., DaSilva, L., Erwin, R. A., Liu, X., Hennighausen, L., Rui, H., and Farrar, W. L. (1997) J. Biol. Chem. 272, 15459-15465
36. Starr, R., and Hilton, D. J. (1999) Bioessays 21, 47-52
37. Pfitzner, E., Jahne, R., Wissler, M., Stoecklin, E., and Groner, B. (1998) Mol. Endocrinol. 12, 1582-1593
38. Milocco, L., Haslam, J. A., Rosen, J., and Seidel, H. M. (1999) Mol. Cell. Biol. 19, 2913-2920
39. Callus, B. A., and Mathey-Prevot, B. (2000) J. Biol. Chem. 275, 16954-16962