Increased levels of keratin 16 alter epithelialization potential of mouse skin keratinocytes in vivo and ex vivo

Molecular Biology of the Cell

Volumn 12, Issue 11, 2001, Pages 3439-3450

  Wawersik, M J ^a   Mazzalupo, S ^a   Nguyen, D ^a   Coulombe, P A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL MIGRATION; EPITHELIZATION; GENETIC ORGANIZATION; INTERMEDIATE FILAMENT; KERATINOCYTE; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; SKIN INJURY; WOUND HEALING;

ANIMALIA; MUS MUSCULUS;

EID: 0035196621     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.11.3439     Document Type: Article

References (55)

1. Epidermal cell migration and wound repair
2. Perfect wound healing in the keratin 8 deficient mouse embryo
3. Programming gene expression in developing epidermis
4. Epidermal growth factor (EGF) promotes keratinocyte locomotion on collagen by increasing the α2 integrin subunit
5. Expression of complete keratin filaments in mouse L cells augments cell migration and invasion
6. Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma cells augments motility
7. Mechanisms of cutaneous wound repair
8. Models of wound healing
9. The cellular and molecular biology of keratins: Beginning a new era
10. Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia
11. Overexpression of human keratin 16 produces a distinct phenotype in transgenic mouse skin
12. Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts
13. Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields
14. A structural scaffolding of intermediate filaments in health and disease
15. Intermediate filaments: Structure, dynamics, function, and disease
16. Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout mice
17. Fate of human keratinocytes during reepithelialization in an organotypic culture model
18. Wound repair, keratinocyte activation and integrin modulation
19. Functional differences between keratins of stratified and simple epithelia
20. Mechanisms of epithelial fusion and repair
21. Neurofilament functions in health and disease
22. A pattern of epidermal cell migration during wound healing
23. Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant
24. Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice
25. Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant
26. Mutation of human keratin 18 in association with cryptogenic cirrhosis
27. Cellular interactions of interactions of integrin alpha3-betal with laminin-5 promotes gap junctional communication
28. A 'hot-spot' mutation alters the mechanical properties of keratin filament networks
29. Activated keratinocytes in the epidermis of hypertrophic scars
30. Lessons from keratin 18 knockout mice: Formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates
31. Changes in keratinocyte maturation during wound healing
32. Wound healing - Aiming for the perfect skin regeneration
33. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during mouse skin development
34. The wound repair associated keratins 6, 16, and 17: Insights into the role of intermediate filaments in specifying cytoarchitecture
35. Acidic fibroblast growth factor accelerates dermal wound healing in diabetic mice
36. The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression
37. Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation
38. The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16
39. Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: Defining a potential role for keratin 16
40. Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
41. Keratinocyte collagenase-1 expression requires an epidermal growth factor receptor autocrine mechanism
42. cDNA cloning, expression, and assembly characteristics of mouse keratin 16
43. Antibody markers of basal cells in complex epithelia
44. + dendritic epidermal cell depletion effects on allograft rejection
45. Quantitative determination of EGF-R during epidermal wound healing
46. A transgenic mouse model with an inducible skin blistering disease phenotype
47. Defining a region of the human keratin 6a gene that confers inducible expression in stratified epithelia of transgenic mice
48. Using transgenic models to study the pathogenesis of keratin-based inherited diseases
49. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin
50. The two functional type II keratin 6 genes of mouse show a differential regulation and evolved independently from their human orthologs
51. Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes
52. A proline residue in the a-helical rod domain of type I keratin 16 destabilizes keratin heterotetramers and influences incorporation into filaments
53. Delayed wound healing in keratin 6a knockout mice
54. Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form mallory bodies