Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice

Journal of Cell Biology

Volumn 143, Issue 7, 1998, Pages 2023-2032

  Ku, Nam On ^a,b   Michie, Sara A ^a,b   Soetikno, Roy M ^a,b   Resurreccion, Evelyn Z ^a,b   Broome, Rosemary L ^a,b   Bishr Omary, M ^a,b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Intermediate filaments; Keratins; Liver; Phosphorylation; Transgenic mice

Indexed keywords

CYANOGINOSIN; GRISEOFULVIN; KERATIN; TOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERMEDIATE FILAMENT; LIVER INJURY; LIVER TOXICITY; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSGENIC MOUSE;

3T3 CELLS; AMINO ACID SUBSTITUTION; ANIMALS; GENETIC PREDISPOSITION TO DISEASE; GRISEOFULVIN; HEPATECTOMY; HEPATITIS, TOXIC; HUMANS; INTERMEDIATE FILAMENTS; KERATINS; LIVER REGENERATION; MICE; MICE, TRANSGENIC; MICROCYSTINS; MICROFILAMENTS; OKADAIC ACID; PEPTIDES, CYCLIC; PHOSPHORYLATION; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL;

ANIMALIA; MUS MUSCULUS;

EID: 0032576580     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.7.2023     Document Type: Article

References (11)

1. Abe, M., and R.G. Oshima. 1990. A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice. J. Cell Biol. 111:1197-1206.
2. Achtstaetter, T., M. Hatzfeld, R.A. Quinlan, D.C. Parmelee, and W.W. Franke. 1986. Separation of cytokeratin polypeptides by gel electrophoretic and chromatographic techniques and their identification by immunoblotting. Methods Enzymol. 134:355-371.
3. Albers, K.M., F.E. Davis, T.N. Perrone, E.Y. Lee, Y. Liu, and M. Vore. 1995. Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities. J. Cell Biol. 128:157-169.
4. Baribault, H., J. Penner, R.V. lozzo, and M. Wilson-Heiner. 1994. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev. 8:2964-2973.
5. Baribault, H., J. Price, K. Miyai, and R.G. Oshima. 1993. Mid-gestational lethality in mice lacking keratin 8. Genes Dev. 7:1191-1202.
6. Bonifas, J.M., A.L. Rothman, and E.H. Epstein, Jr. 1991. Epidermolysis bullosa simplex: evidence in two familes for keratin gene abnormalities. Science. 254:1202-1205.
7. Boyle, W.J., P. Van Der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin layer cellulose plates. Methods Enzymol. 201:110-149.
8. Caulin, C, G.S. Salvesen, and R.G. Oshima. 1997. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J. Cell Biol. 138:1379-1394.
9. Chiprut, R.O., A. Viteri, C. Jamroz, and W.P. Dyck. 1976. Intrahepatic cholestasis after griseofulvin administration. Gastroenterology. 70:1141-1143.
10. Chou, C.-F., and M.B. Omary. 1993. Mitotic-arrest associated enhancement of O-linked glycosylation and phosphorylation of human keratins 8 and 18. J. Biol. Chem. 268:4465-4472.
11. Chou, C.-F., A.J. Smith, and M.B. Omary. 1992. Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. J. Biol. Chem. 267:3901-3906.