메뉴 건너뛰기




Volumn 98, Issue 4, 1996, Pages 1034-1046

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant

Author keywords

acetaminophen; glycosylation; griseofulvin; liver; phosphorylation

Indexed keywords

GRISEOFULVIN; KERATIN; KERATIN 18; PARACETAMOL; UNCLASSIFIED DRUG;

EID: 0029789008     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118864     Document Type: Article
Times cited : (107)

References (53)
  • 1
    • 0020467073 scopus 로고
    • The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
    • Moll, R., W.W. Franke, D.L. Schiller, B. Geiger, and R. Krepler. 1982. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 31:11-24.
    • (1982) Cell , vol.31 , pp. 11-24
    • Moll, R.1    Franke, W.W.2    Schiller, D.L.3    Geiger, B.4    Krepler, R.5
  • 2
    • 0023951297 scopus 로고
    • Molecular and cellular biology of intermediate filaments
    • Steinert, P.M., and D.R. Roop. 1988. Molecular and cellular biology of intermediate filaments. Ann. Rev. Biochem. 57:593-625.
    • (1988) Ann. Rev. Biochem. , vol.57 , pp. 593-625
    • Steinert, P.M.1    Roop, D.R.2
  • 3
    • 0028283501 scopus 로고
    • Intermediate filaments: Structure, dynamics, function and disease
    • Fuchs, E., and Weber, K. 1994. Intermediate filaments: structure, dynamics, function and disease. Annu. Rev. Biochem. 63:345-382.
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 345-382
    • Fuchs, E.1    Weber, K.2
  • 4
    • 0026627851 scopus 로고
    • Of mice and men: Genetic skin diseases of keratin
    • Fuchs, E., and P.A. Coulombe. 1992. Of mice and men: genetic skin diseases of keratin. Cell. 69:899-902.
    • (1992) Cell , vol.69 , pp. 899-902
    • Fuchs, E.1    Coulombe, P.A.2
  • 5
    • 0027184893 scopus 로고
    • Genetic skin diseases caused by mutations in keratin intermediate filaments
    • Steinert, P.M., and S.J. Bale. 1993. Genetic skin diseases caused by mutations in keratin intermediate filaments. Trends Genet. 9:280-284.
    • (1993) Trends Genet. , vol.9 , pp. 280-284
    • Steinert, P.M.1    Bale, S.J.2
  • 6
    • 0027941548 scopus 로고
    • Cracks in the foundation: Keratin filaments and genetic disease
    • Fuchs, E., Y-M. Chan, A.S. Paller, and Q-C. Yu. 1994. Cracks in the foundation: keratin filaments and genetic disease. Trends Cell Biol. 4:321-326.
    • (1994) Trends Cell Biol. , vol.4 , pp. 321-326
    • Fuchs, E.1    Chan, Y.-M.2    Paller, A.S.3    Yu, Q.-C.4
  • 11
    • 0028844205 scopus 로고
    • Keratin 13 point mutation underlies the hereditary mucosal epithelia disorder white sponge nevus
    • Richard, G., V. De Laurenzi, B. Didona, S.J. Bale, and J.G. Compton. 1995. Keratin 13 point mutation underlies the hereditary mucosal epithelia disorder white sponge nevus. Nature Genet. 11:453-455.
    • (1995) Nature Genet. , vol.11 , pp. 453-455
    • Richard, G.1    De Laurenzi, V.2    Didona, B.3    Bale, S.J.4    Compton, J.G.5
  • 12
    • 0028001606 scopus 로고
    • Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerrosis
    • Figlewicz, D.A., A. Krizus, M.G. Martinoli, V. Meininger, M. Dib, G.A. Rouleau, and J.-P. Julien. 1994. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerrosis. Hum. Mol. Genet. 3:1757-1761.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 1757-1761
    • Figlewicz, D.A.1    Krizus, A.2    Martinoli, M.G.3    Meininger, V.4    Dib, M.5    Rouleau, G.A.6    Julien, J.-P.7
  • 13
    • 0025976155 scopus 로고
    • Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease
    • Vassar, R., P.A. Coulombe, L. Degenstein, K. Albers, and E. Fuchs. 1991. Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell. 64:365-380.
    • (1991) Cell , vol.64 , pp. 365-380
    • Vassar, R.1    Coulombe, P.A.2    Degenstein, L.3    Albers, K.4    Fuchs, E.5
  • 14
    • 0025861772 scopus 로고
    • Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analysis
    • Coulombe, P.A., M.E. Hutton, A. Letai, A. Hebert, A.S. Paller, and E. Fuchs. 1991. Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: Genetic and functional analysis. Cell. 66:1301-1311.
    • (1991) Cell , vol.66 , pp. 1301-1311
    • Coulombe, P.A.1    Hutton, M.E.2    Letai, A.3    Hebert, A.4    Paller, A.S.5    Fuchs, E.6
  • 15
    • 0027227464 scopus 로고
    • Mid-gestational lethality in mice lacking keratin 8
    • Baribault, H., R. Price, K. Miyai, and R.G. Oshima. 1993. Mid-gestational lethality in mice lacking keratin 8. Genes & Dev. 7:1191-1202.
    • (1993) Genes & Dev. , vol.7 , pp. 1191-1202
    • Baribault, H.1    Price, R.2    Miyai, K.3    Oshima, R.G.4
  • 16
    • 0028607055 scopus 로고
    • Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
    • Baribault, H., J. Penner, R.V. Iozzo, and M. Wilson-Heiner. 1994. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes & Dev. 8:2964-2973.
    • (1994) Genes & Dev. , vol.8 , pp. 2964-2973
    • Baribault, H.1    Penner, J.2    Iozzo, R.V.3    Wilson-Heiner, M.4
  • 17
    • 0027454775 scopus 로고
    • Ectopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production
    • Blessing, M., U. Ruther, and W.W. Franke. 1993. Ectopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production. J. Cell Biol. 120:743-755.
    • (1993) J. Cell Biol. , vol.120 , pp. 743-755
    • Blessing, M.1    Ruther, U.2    Franke, W.W.3
  • 18
    • 0028836521 scopus 로고
    • Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities
    • Albers, K.M., F.E. Davis, T.N. Perrone, E.Y. Lee, Y. Liu, and M. Vore. 1995. Expression of an epidermal keratin protein in liver of transgenic mice causes structural and functional abnormalities. J. Cell Biol. 128:157-169.
    • (1995) J. Cell Biol. , vol.128 , pp. 157-169
    • Albers, K.M.1    Davis, F.E.2    Perrone, T.N.3    Lee, E.Y.4    Liu, Y.5    Vore, M.6
  • 19
    • 0028865145 scopus 로고
    • Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant
    • Ku, N-O., S. Michie, R.G. Oshima, and M.B. Omary. 1995. Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant. J. Cell Biol. 131: 1303-1314.
    • (1995) J. Cell Biol. , vol.131 , pp. 1303-1314
    • Ku, N.-O.1    Michie, S.2    Oshima, R.G.3    Omary, M.B.4
  • 20
    • 0025076790 scopus 로고
    • A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice
    • Abe, M., and R.G. Oshima. 1990. A single human keratin 18 gene is expressed in diverse epithelial cells of transgenic mice. J. Cell Biol. 111:1197-1206.
    • (1990) J. Cell Biol. , vol.111 , pp. 1197-1206
    • Abe, M.1    Oshima, R.G.2
  • 21
    • 0029086094 scopus 로고
    • Heat stress or rotavirus infection of human epithelial cells generates a distinct hyperphosphorylated form of keratin 8
    • Liao, J., L.A. Lowthert, and M.B. Omary. 1995. Heat stress or rotavirus infection of human epithelial cells generates a distinct hyperphosphorylated form of keratin 8. Exp. Cell Res. 219:348-357.
    • (1995) Exp. Cell Res. , vol.219 , pp. 348-357
    • Liao, J.1    Lowthert, L.A.2    Omary, M.B.3
  • 22
    • 0027506091 scopus 로고
    • Mitotic-arrest associated enhancement of O-linked glycosylation and phosphorylation of human keratins 8 and 18
    • Chou, C-F., and M.B. Omary. 1993. Mitotic-arrest associated enhancement of O-linked glycosylation and phosphorylation of human keratins 8 and 18. J. Biol. Chem. 268:4465-4472.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4465-4472
    • Chou, C.-F.1    Omary, M.B.2
  • 23
    • 0028360655 scopus 로고
    • Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's
    • Chou, C-F., and M.B. Omary. 1994. Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's. J. Cell Sci. 107:1833-1843.
    • (1994) J. Cell Sci. , vol.107 , pp. 1833-1843
    • Chou, C.-F.1    Omary, M.B.2
  • 24
    • 0028853614 scopus 로고
    • Dynamics of human keratin 18 phosphorylation: Polarized distribution of phosphorylated keratins in simple epithelial tissues
    • Liao, J., L.A. Lowthert, N-O. Ku, R. Fernandez, and M.B. Omary. 1995. Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues. J. Cell Biol. 131:1291-1301.
    • (1995) J. Cell Biol. , vol.131 , pp. 1291-1301
    • Liao, J.1    Lowthert, L.A.2    Ku, N.-O.3    Fernandez, R.4    Omary, M.B.5
  • 25
    • 0002646734 scopus 로고
    • Cirrhosis of the liver. Five different types of lesions from which it may arise
    • Mallory, F.B. 1911. Cirrhosis of the liver. Five different types of lesions from which it may arise. Bull. Johns Hopkins Hosp. 22:69-75.
    • (1911) Bull. Johns Hopkins Hosp. , vol.22 , pp. 69-75
    • Mallory, F.B.1
  • 26
    • 0016593197 scopus 로고
    • Hepatocellular hyalin (Mallory bodies) in long term griseofulvin-treated mice: A new experimental model for the study of hyalin formation
    • Denk, H., F. Gschnait, and K. Wolff. 1975. Hepatocellular hyalin (Mallory bodies) in long term griseofulvin-treated mice: a new experimental model for the study of hyalin formation. Lab. Invest. 32:773-776.
    • (1975) Lab. Invest. , vol.32 , pp. 773-776
    • Denk, H.1    Gschnait, F.2    Wolff, K.3
  • 27
    • 0002472712 scopus 로고
    • Toxic liver damage in mice after prolonged intake of elevated doses of griseofulvin
    • Barich, L.L., J. Schwarz, D.J. Barich, and M.G. Horowitz. 1961. Toxic liver damage in mice after prolonged intake of elevated doses of griseofulvin. Antibiot. Chemother. 11:566-571.
    • (1961) Antibiot. Chemother. , vol.11 , pp. 566-571
    • Barich, L.L.1    Schwarz, J.2    Barich, D.J.3    Horowitz, M.G.4
  • 28
    • 84980113075 scopus 로고
    • Protoporphyrin, cirrhosis and hepatomata in the livers of mice given griseofulvin
    • Weston Hurst, E., and G.E. Paget. 1963. Protoporphyrin, cirrhosis and hepatomata in the livers of mice given griseofulvin. Br. J. Dermatol. 75:105-112.
    • (1963) Br. J. Dermatol. , vol.75 , pp. 105-112
    • Weston Hurst, E.1    Paget, G.E.2
  • 29
    • 0028021248 scopus 로고
    • Post-translational events involved in griseofulvin-induced keratin cytoskeleton alterations
    • Salmhofer, H., I. Rainer, K. Zatloukal, and H. Denk. 1994. Post-translational events involved in griseofulvin-induced keratin cytoskeleton alterations. Hepatology. 20:731-740.
    • (1994) Hepatology , vol.20 , pp. 731-740
    • Salmhofer, H.1    Rainer, I.2    Zatloukal, K.3    Denk, H.4
  • 31
    • 0000380274 scopus 로고
    • Drug metabolism and hepatotoxicity
    • N. Kaplowitz, editor. Williams and Wilkins, Baltimore, MD
    • Kaplowitz, N. Drug metabolism and hepatotoxicity. 1992. In Liver and Biliary Diseases. N. Kaplowitz, editor. Williams and Wilkins, Baltimore, MD.
    • (1992) Liver and Biliary Diseases
    • Kaplowitz, N.1
  • 34
    • 0028817867 scopus 로고
    • Drug-induced hepatotoxicity
    • Lee, W.M. Drug-induced hepatotoxicity. 1995. N. Engl. J. Med. 17: 1118-1127.
    • (1995) N. Engl. J. Med. , vol.17 , pp. 1118-1127
    • Lee, W.M.1
  • 35
    • 0026662974 scopus 로고
    • Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18
    • Chou, C-F., A.J. Smith, and M.B. Omary. 1992. Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18. J. Biol. Chem. 267:3901-3906.
    • (1992) J. Biol. Chem. , vol.267 , pp. 3901-3906
    • Chou, C.-F.1    Smith, A.J.2    Omary, M.B.3
  • 36
    • 0026571064 scopus 로고
    • S-Adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models
    • Bray, G.P., J.M. Tredger, and R. Williams. 1992. S-Adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models. Hepatology. 15:297-301.
    • (1992) Hepatology , vol.15 , pp. 297-301
    • Bray, G.P.1    Tredger, J.M.2    Williams, R.3
  • 38
    • 0028209107 scopus 로고
    • Proliferating cell nuclear antigen (PCNA) expression in regenerating rat liver after partial hepatectomy
    • Theocharis, S.E., A.S. Skopelitou, A.P. Margeli, K.J. Pavlaki, and C. Kittas. 1994. Proliferating cell nuclear antigen (PCNA) expression in regenerating rat liver after partial hepatectomy. Dig. Dis. Sci. 39:245-252.
    • (1994) Dig. Dis. Sci. , vol.39 , pp. 245-252
    • Theocharis, S.E.1    Skopelitou, A.S.2    Margeli, A.P.3    Pavlaki, K.J.4    Kittas, C.5
  • 40
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
    • (1970) Nature (Lond.) , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 41
    • 0029063952 scopus 로고
    • Identification and mutational analysis of the glycosylation sites of human keratin 18
    • Ku, N-O., and M.B. Omary. 1995. Identification and mutational analysis of the glycosylation sites of human keratin 18. J. Biol. Chem. 270:11820-11827.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11820-11827
    • Ku, N.-O.1    Omary, M.B.2
  • 42
    • 0028829588 scopus 로고
    • Liver regeneration
    • Steer, C.J. 1995. Liver regeneration. FASEB J. 9:1396-1400.
    • (1995) FASEB J. , vol.9 , pp. 1396-1400
    • Steer, C.J.1
  • 43
    • 0001276586 scopus 로고
    • Experimental pathology of the liver
    • Higgins, G.M., and R.M. Anderson. 1931. Experimental pathology of the liver. Arch. Path. 12:186-202.
    • (1931) Arch. Path. , vol.12 , pp. 186-202
    • Higgins, G.M.1    Anderson, R.M.2
  • 45
    • 0028106972 scopus 로고
    • Identification of the major physiologic phosphorylation site of human keratin 18: Potential kinases and a role in filament reorsanization
    • Ku, N-O., and M.B. Omary. 1994. Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorsanization. J. Cell Biol. 127:161-171.
    • (1994) J. Cell Biol. , vol.127 , pp. 161-171
    • Ku, N.-O.1    Omary, M.B.2
  • 46
    • 0027327669 scopus 로고
    • The genetic basis of Weber-Cockayne epidermolysis bullosa simplex
    • Chan, Y.-M., Q.-C Yu, J.-D Fine, and E. Fuchs. 1993. The genetic basis of Weber-Cockayne epidermolysis bullosa simplex. Proc. Natl. Acad. Sci. USA. 90:7414-7418.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7414-7418
    • Chan, Y.-M.1    Yu, Q.-C.2    Fine, J.-D.3    Fuchs, E.4
  • 48
    • 0029111799 scopus 로고
    • Oxidative stress by acute acetaminophen administration in mouse liver
    • Arnaiz, S.L., S. Llesuy, J.C. Cutrin, and A. Boveris. 1995. Oxidative stress by acute acetaminophen administration in mouse liver. Free Radic. Biol. Med. 19:303-310.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 303-310
    • Arnaiz, S.L.1    Llesuy, S.2    Cutrin, J.C.3    Boveris, A.4
  • 49
    • 0017622946 scopus 로고
    • Alteration of hepatic microsomal enzymes by griseofulvin treatment of mice
    • Denk, H., R. Eckerstorfer, R.E. Talcott, and J.B. Schenkman. 1977. Alteration of hepatic microsomal enzymes by griseofulvin treatment of mice. Biochem. Pharmacol. 26:1125-1130.
    • (1977) Biochem. Pharmacol. , vol.26 , pp. 1125-1130
    • Denk, H.1    Eckerstorfer, R.2    Talcott, R.E.3    Schenkman, J.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.