A regulatory role for Src homology 2 domain-containing inositol 5′-phosphatase (SHIP) in phagocytosis mediated by Fcγ receptors and complement receptor 3 (αMβ2; CD11b/CD18)

Journal of Experimental Medicine

Volumn 193, Issue 1, 2001, Pages 61-71

  Cox, D ^a   Dale, B M ^a   Kashiwada, M ^a   Helgason, C D ^a   Greenberg, S ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Actin; Integrin; Leukocyte; Macrophage; Phosphatidylinositol 3 kinase

Indexed keywords

ACTIN; CD11B ANTIGEN; CD18 ANTIGEN; COMPLEMENT RECEPTOR; FC RECEPTOR; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE P60;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CYTOSKELETON; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; COS CELLS; CYTOSKELETON; MACROPHAGE-1 ANTIGEN; MICE; MICE, KNOCKOUT; PHAGOCYTOSIS; PHAGOSOMES; PHOSPHORIC MONOESTER HYDROLASES; RECEPTORS, IGG; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 0035188021     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.1.61     Document Type: Article

References (57)

1. A requirement for phosphatidylinositol 3-kinase in pseudopod extension
2. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
3. The role of SHIP in growth factor induced signalling
4. Structure, function, and biology of SHIP proteins
5. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
6. SHIP modulates immune receptor responses by regulating membrane association of BTK
7. 3)/Tec kdnase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
8. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fcγ RIIB
9. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation
10. The SH2-containing 5′-inositol phosphatase (SHIP) is tyrosine phosphorylated after Fcγ receptor clustering in monocytes
11. The human high-affinity immunoglobulin G receptor activates SH2-containing inositol phosphatase (SHIP)
12. i flux in Fcγ RIIA signaling
13. Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cb1 in Fcγ receptor signaling
14. Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc∈R1 cross-linking
15. Complement receptor, adhesion, and phagocytosis
16. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
17. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTP-ases
18. Involvement of phosphatidylinositol 3-kinase in Fcγ receptor signaling
19. 2 integrin engagement triggers actin polymerization and phosphatidylinositol trisphosphate formation in non-adherent human neutrophils
20. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages
21. Evidence for the involvement of phosphatidylinositol 4, 5-bisphosphate 3-kinase in CD18-mediated adhesion of human neutrophils to fibrinogen
22. 2 avidity in polymorphonuclear neutrophils
23. αLβ2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule
24. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
25. 2+ levels
26. A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
27. SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase
28. 3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
29. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis
30. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages
31. A wortmannin sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids
32. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
33. Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
34. Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling
35. T lymphocyte activation: The role of tyrosine phosphorylation
36. Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
37. Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation
38. IL-2 induces β2-integrin adhesion via a wortmannin/LY294002-sensitive, rapamycin resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with induction of adhesion, but not mitogenesis
39. Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and phosphatidylinositol 3-kinase
40. Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2
41. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling
42. Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP
43. The SH2 domain-containing inositol 5′-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcγRIIb1-mediated inhibition of B cell receptor signaling
44. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
45. Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
46. Identification and analysis of PH domaincontaining targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
47. Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase
48. Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice
49. Biphasic formation of inositol phosphates in opsonized zymosan-stimulated human neutrophils
50. Role of the C2B domain of synaptotagmin in vesicular release and recycling as determined by specific antibody injection into the squid giant synapse preterminal
51. Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetra-kisphosphate binding to synaptotagmins III, V, and X
52. v-SNARE-dependent secretion is required for phagocytosis
53. Mutation of the pleckstrin homology, domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity
54. m. Determination of the inositol 1,3,4,5-tetrakisphophate-binding domain
55. Differences in the mode of phagocytosis with Fc and C3 receptors in macrophages
56. The SH2-containing inositol-5′-phosphatase enhances LFA-1-mediated cell adhesion and defines two signaling pathways for LFA-1 activation
57. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span