Alcohol-xenobiotics interactions. Role of cytochrome P450 2E1;Interactions alcool-xénobiotiques. Rôle du cytochrome P450 2E1

Pathologie Biologie

Volumn 49, Issue 9, 2001, Pages 696-702

  Meskar, A ^a   Plee Gautier, E ^a   Amet, Y ^a   Berthou, F ^a   Lucas, D ^a  

^a FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

Author keywords

Alcohol; CYP2E1; Cytochromes; P450; Toxicity; Xenobiotics

Indexed keywords

ALCOHOL; BENZENE DERIVATIVE; CARBON TETRACHLORIDE; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; ENFLURANE; HALOTHANE; NITROSAMINE; PARACETAMOL; TOBACCO SMOKE; TRICHLOROETHYLENE; XENOBIOTIC AGENT;

ALCOHOL CONSUMPTION; ALCOHOL OXIDATION; ALCOHOL TOLERANCE; ALCOHOLISM; ARTICLE; DRUG TOLERANCE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HUMAN; LIVER CELL; MOLECULAR INTERACTION; OXIDATION;

ACETAMINOPHEN; CARCINOGENS; CYTOCHROME P-450 CYP2E1; DRUG INTERACTIONS; ENZYME INDUCTION; ETHANOL; HUMANS; MICROSOMES, LIVER; NITROSAMINES; OXIDATION-REDUCTION; SOLVENTS; XENOBIOTICS;

EID: 0035183321     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0369-8114(01)00235-8     Document Type: Article

References (45)

1. Le métabolisme de l'alcool et ses variations au cours de l'alcoolisme aigu et de l'alcoolisme chronique
2. Ethanol oxidation by hepatic microsomes: Adaptative increase after ethanol feeding
3. Respective roles of human cytochrome P450 2E1, 1A2 and 3A4 in the hepatic microsomal ethanol oxidizing system
4. Role of metabolism in chemical toxicity
5. Oxidation of toxic and carcinogenic chemicals by human cytochrome P450 enzymes
6. Interactions alcool-médicaments. II. Spécificités selon les classes thérapeutiques
7. P450 superfamily: Update on new sequences, gene mapping, accession numbers, and nomenclature
8. Oxidative and reductive metabolism by cytochrome P450 2E1
9. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450
10. Hepatic microsomal ethanol metabolism (MEOS); metabolic and clinical aspects
11. Le métabolisme de l'éthanol: Hépatotoxicité et interaction avec les médicaments, les carcinogènes et les vitamines
12. Cytochrome P450 2E1 in rat liver, kidney and lung microsomes after chronic administration of ethanol either orally or by inhalation
13. Effects of dietary fat consumption on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 in the liver of rats chronically fed ethanol
14. Diet and risk of ethanol-induced hepatotoxicity: Carbohydrate-fat relationships in rats
15. Induction of cytochrome P450 2E1 during ethanol exposure occurs via transcription of the CYP2E1 gene when blood concentrations are high
16. Modulation of cytochrome P450 isozymes in human liver by ethanol and drug intake
17. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450 IIE1
18. Human lymphocyte cytochrome P450 2E1, a putative marker of alcohol-mediated changes in hepatic chlorzoxazone activity
19. Decrease in cytochrome P4502E1 as assessed by the rate of chlorzoxazone hydroxylation in alcoholics during the withdrawal phase
20. Microsomal Ethanol-oxidizing system (MEOS): The first 30 years (1968-1998) - A review
21. Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans
22. Multiple mechanisms in the regulation of ethanol-inducible cytochrome P450 IIE1
23. Rapid changes in cytochrome P4502E1 (CYP2E1) activity and other P450 isozymes following ethanol withdrawal in rats
24. Induction of P4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA
25. Genetic polymorphism in the 5′-flanking region change transcriptional regulation of the human cytochrome P450 IIE1 gene
26. Cytochrome P4502E1 genotype and chlorzoxazone metabolism in healthy and alcoholic caucasian subjects
27. Urinary 6β-hydroxycortisol excretion in patients with alcoholic liver diseases
28. Impact of long-term ethanol consumption on CYP1A2 activity
29. Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol
30. Clinical and toxicological consequences of the inductive potential of ethanol
31. Ethanol interaction with other cytochrome P450 substrates including drugs, xenobiotics and carcinogens
32. Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics
33. CYP2E1 activity in patients with alcoholic liver disease
34. Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans
35. Induction of human drug-metabolizing enzymes
36. Mechanism by which ethanol diminishes the hepatotoxicity of acetaminophen
37. Alcohol-mediated increases in acetaminophen hepatotoxicity - Role of CYP2E and CYP3A
38. Bioactivation of halogenated hydrocarbons by cytochrome P450 2E1
39. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression
40. Metabolism of N-nitrosodialkylamines by human liver microsomes
41. Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes
42. Cytochrome P450 IIE1: Roles in nitrosamine metabolism and mechanisms of regulation
43. Ethanol-inducible cytochrome P-450: Assessment of substrates specific chemical probes in rat liver microsomes
44. Alcohol-related cancer risk: A toxicokinetic hypothesis
45. Nitrosamine carcinogenesis: Rodent assays, quantitative structure activity relationships, and human risk assessment