Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections

Journal of Antimicrobial Chemotherapy

Volumn 48, Issue 5, 2001, Pages 677-689

  Ioannidis, John P A ^a,b   Contopoulos Ioannidis, Despina G ^a,c   Chew, Priscilla ^b   Lau, Joseph ^b  

^a UNIVERSITY OF IOANNINA   (Greece)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZITHROMYCIN; BETA LACTAMASE INHIBITOR; CEFACLOR; CEPHALOSPORIN; CLARITHROMYCIN; COTRIMOXAZOLE; DIRITHROMYCIN; ERYTHROMYCIN; MACROLIDE; PENICILLIN G; ROXITHROMYCIN; JOSAMYCIN;

ARTICLE; BACTERIOLOGY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COST; DRUG EFFICACY; DRUG INDICATION; DRUG SAFETY; DRUG TOXICITY; DRUG WITHDRAWAL; HUMAN; MAJOR CLINICAL STUDY; META ANALYSIS; OTITIS MEDIA; OUTCOMES RESEARCH; PHARYNGITIS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SIDE EFFECT; SINUSITIS; TREATMENT FAILURE; ADVERSE DRUG REACTION; BACTERIAL PNEUMONIA; BRONCHITIS; CHRONIC BRONCHITIS; DISEASE EXACERBATION; GASTROINTESTINAL SYMPTOM; HYPERKINESIA; LOWER RESPIRATORY TRACT INFECTION; PARESTHESIA; PNEUMONIA; RASH; STATISTICAL ANALYSIS; URTICARIA; VIRUS PNEUMONIA;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BRONCHITIS; CHI-SQUARE DISTRIBUTION; CHRONIC DISEASE; COMMUNITY-ACQUIRED INFECTIONS; CONFIDENCE INTERVALS; HUMANS; ODDS RATIO; PNEUMONIA; RANDOMIZED CONTROLLED TRIALS; RESPIRATORY TRACT INFECTIONS;

EID: 0035183051     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/48.5.677     Document Type: Article

References (78)

1. Spectrum and mode of action of azithromycin, a new 15-membered ring macrolide with improved potency against Gram-negative organisms
2. Are amoxycillin and folate inhibitors as effective as other antibiotics for acute sinusitis? A meta-analysis
3. Primary-care based randomised placebo-controlled trial of antibiotic treatment in acute maxillary sinusitis
4. The end of antibiotic treatment in adults with acute sinusitis-like complaints in general practice? A placebo-controlled double-blind randomized doxycycline trial
5. Is amoxicillin more effective than placebo in treating acute otitis media in children younger than 2 years?
6. Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years
7. Co-amoxiclav in recurrent acute otitis media: Placebo controlled study
8. Randomized controlled trial of 3 vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis
9. Treatment of acute otitis media with a shortened course of antibiotics: A meta-analysis
10. Single-dose ceftriaxone versus 10 days cefaclor for otitis media
11. Single-dose intramuscular ceftriaxone for acute otitis media in children
12. Intramuscular ceftriaxone compared with oral amoxicillin-clavulanate for treatment of acute otitis media in children
13. Comparison of ceftriaxone and trimethoprim-sulfamethoxazole for acute otitis media
14. Short-term treatment of streptococcal tonsillitis with ceftriaxone
15. Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infections
16. Quantitative synthesis in systematic reviews
17. Statistical aspects of the analysis of data from retrospective studies of disease
18. Meta-analysis in clinical trials
19. Recursive cumulative meta-analysis: A diagnostic for the evolution of total randomized evidence from group and individual patient data
20. An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis in clinical trials
21. Comparative trial of 3 days azithromycin versus 10-day amoxicillin/clavulanate potassium in the treatment of children with acute otitis media with effusion
22. Comparative trial of 3 days of azithromycin versus 10 days of clarithromycin in the treatment of children with acute otitis media with effusion
23. A multicenter, open label trial of azithromycin vs. amoxicillin/clavulanate for the management of acute otitis media in children
24. Comparison of azithromycin, amoxicillin/clavulanic acid and cefaclor in the treatment of acute ear, nose throat infections
25. Economic analysis of antibiotic regimens used in the treatment of pharyngitis: A prospective comparison of azithromycin versus roxithromycin
26. Azithromycin and amoxicillin in the treatment of acute maxillary sinusitis
27. A comparison of the efficacy, tolerability and safety of azithromycin and co-amoxiclav in the treatment of sinusitis in adults
28. Azithromycin versus cefaclor in the treatment of pediatric patients with acute group a beta-hemolytic streptococcal tonsillopharyngitis
29. Open comparative study of the efficacy and tolerability of azithromycin versus amoxicillin in the treatment of acute rhinosinusitis
30. Bacteriologic and clinical efficacy of amoxicillin/clavulanate vs. azithromycin in acute otitis media
31. Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children
32. Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome
33. Comparison of azithromycin and co-amoxiclav in the treatment of otitis media in children
34. A comparison of azithromycin and penicillin V for the treatment of streptococcal pharyngitis and tonsillitis in children
35. Short-course treatment of sinusitis and other upper respiratory tract infections with azithromycin: A comparison with erythromycin and amoxycillin
36. Azithromycin: 3-day versus 5-day course in the treatment of respiratory tract infections in children
37. Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: Azithromycin versus ceftibuten
38. Increased carriage of resistant non-pneumococcal alpha-hemolytic streptococci after antibiotic therapy
39. Multicentre evaluation of azithromycin and penicillin V in the treatment of acute streptococcal pharyngitis and tonsillitis in children
40. Azithromycin versus placebo in acute infectious rhinitis with clinical symptoms but without radiological signs of maxillary sinusitis
41. Efficacy and safety of azithromycin versus phenoxymethylpenicillin in the treatment of acute maxillary sinusitis
42. A comparison of azithromycin and penicillin V for the treatment of streptococcal pharyngitis
43. Clinical safety and tolerance of azithromycin in children
44. Comparative trial of 3-day azithromycin versus 10-day coamoxiclav course efficacy in acute sinusitis
45. A multicenter, randomized, open label comparison of azithromycin and amoxicillin/clavulanate in acute otitis media among children attending day care or school
46. Streptococcal pharyngitis: Alternative treatments
47. Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis
48. Clinical comparative study of azithromycin versus erythromycin in the treatment of acute respiratory tract infections in children
49. A multicenter, double blind comparison of azithromycin and amoxicillin/clavulanate for the treatment of acute otitis media in children
50. A comparative study of azithromycin and amoxycillin in paediatric patients with acute otitis media
51. An open comparative study of azithromycin and roxithromycin in the treatment of acute upper respiratory tract infections
52. Comparison of azithromycin versus clarithromycin in the treatment of patients with upper respiratory tract infections
53. An open comparative study of azithromycin versus cefaclor in the treatment of patients with upper respiratory tract infections
54. Azithromycin versus penicillin V in the treatment of paediatric patients with acute streptococcal pharyngitis/tonsillitis
55. Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children
56. Comparison of clarithromycin and azithromycin for treatment of streptococcal pharyngotonsillitis in children
57. Azithromycin in upper respiratory tract infections: A clinical trial in children with otitis media
58. Multicentre comparative study of the efficacy and safety of azithromycin compared with amoxicillin/clavulanic acid in the treatment of paediatric patients with otitis media
59. Comparative safety and efficacy of clarithromycin and azithromycin suspensions in the short course treatment of children with acute otitis media
60. An open study to compare azithromycin with cefaclor in the treatment of children with acute otitis media
61. Interpretation of middle ear fluid concentrations of antibiotic: Comparison between ceftibuten, cefixime and azithromycin
62. Evaluation of the efficacy, safety and toleration of azithromycin vs. penicillin V in the treatment of acute streptococcal pharyngitis in children: Results of a multicenter, open comparative study
63. Multicentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children
64. Azithromycin compared with clarithromycin for the treatment of streptococcal pharyngitis in children
65. Multicentre comparison of azithromycin versus erythromycin in the treatment of paediatric pharyngitis or tonsillitis caused by group A streptococci
66. Claims of equivalence in medical research: Are they supported by the evidence?
67. Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis
68. State of the evidence: Current status and prospects of meta-analysis in infectious diseases
69. Antibiotics for persistent nasal discharge (rhinosinusitis) in children
70. Antibiotics for acute maxillary sinusitis
71. One dose ceftriaxone vs ten days of amoxicillin/clavulanate therapy for acute otitis media: Clinical efficacy and change in nasopharyngeal flora
72. Two versus seven days penicillin treatment for acute otitis media. A placebo controlled trial in children
73. Streptococcal pharyngitis: Current therapy and criteria for evaluation of new agents
74. Five versus ten days treatment of group A streptococcal pharyngotonsillitis: A randomized controlled clinical trial with phenoxymethylpenicillin and cefadroxil
75. Completeness of safety reporting in randomized trials: An evaluation of 7 medical areas
76. Reporting of safety data from randomised trials
77. Serum and WBC pharmacokinetics of 1500 mg of azithromycin when given either as a single dose or over a 3 day period in healthy volunteers
78. A controlled trial of a single dose of azithromycin for the treatment of chlamydia urethritis and cervicitis