Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 1, 2000, Pages 43-50

  Dagan, Ron ^a   Leibovitz, Eugene ^a   Fliss, Dan M ^b   Leiberman, Alberto ^b   Jacobs, Michael R ^c   Craig, William ^d   Yagupsky, Pablo ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CEFACLOR;

ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; CHILD; DRUG EFFICACY; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OTITIS MEDIA; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

EID: 0033989601     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.1.43-50.2000     Document Type: Article

References (50)

1. Appelbaum, P. C. 1992. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin. Infect. Dis. 15:77-83.
2. Aronovitz, C. 1996. A multicenter open label trial of azithromycin vs. amoxicillin clavulanate for the management of acute otitis media in children. Pediatr. Infect. Dis. J. 15:S15-S19.
3. Austrian, R. 1976. The Quellung reaction, a neglected microbiologic technique. Mt. Sinai J. Med. 43:669-705.
4. Baquero, F., J. Martinez-Beltran, and R. Loza. 1991. A review of antibiotic resistance patterns of Streptococcus pneumoniae in Europe. J. Antimicrob. Chemother. 28 (Suppl. C):31-38.
5. Barnett, E. D., and J. O. Klein. 1995. The problem of resistant bacteria for the management of acute otitis media. Pediatr. Clin. N. Am. 42:509-517.
6. Bergeron, M. G., G. Ahronheim, J. E. Richard, K. Riding, C. Cron, D. Bryer, N. Macdonald, M. Bouchard, J. Young, and E. E. Dempsey. 1987. Comparative efficacies of erythromycin-sulfisoxazole and cefaclor in acute otitis media: a double bind randomized trial. Pediatr. Infect. Dis. J. 6:654-660.
7. Block, S., J. Hedrick, P. Wright, R. Finger, R. Leggiadro, M. Appleton, S. Kahn, and R. Hutcheson. 1994. Drug-resistant Streptococcus pneumoniae - Kentucky and Tennessee, 1993. Morbid. Mortal. Weekly Rep. 43:23-25.
8. Carlin, S. A., C. D. Marchant, P. A. Shurin, C. E. Johnson, D. M. Super, and J. M. Rehmus. 1991. Host factors and early therapeutic response in acute otitis media. J. Pediatr. 118:178-183.
9. Craig, W. A. 1997. Postantibiotic effects and the dosing of macrolides, azalides, and streptogramins. In S. H. Zinner, L. S. Young, J. F. Acar, and H. C. Neu (ed.), Expanding indications for the new macrolides, azalides, and streptogramins. Marcel Dekker, Inc., New York, N.Y.
10. Craig, W. A. 1998. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin. Infect. Dis. 26:1-10.
11. Craig, W. A., and D. Andes. 1996. Pharmacokinetics and pharmacodynamics of antibiotics in otitis media. Pediatr. Infect. Dis. J. 15:255-259.
12. Dagan, R., E. Leibovitz, D. Greenberg, P. Yagupsky, D. M. Fliss, and A. Leiberman. 1998. Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome. Pediatr. Infect. Dis. J. 17:776-782.
13. Dagan, R., O. Abramson, E. Leibovitz, R. Lang, S. Goshen, D. Greenberg, P. Yagupsky, A. Leiberman, and D. Fliss. 1996. Impaired bacteriologic response to oral cephalosporins in acute otitis media caused by pneumococci with intermediate resistance to penicillin. Pediatr. Infect. Dis. J. 15:980-985.
14. Dagan, R., O. Abramson, E. Leibovitz, D. Greenberg, R. Lang, S. Goshen, P. Yagupsky, A. Leiberman, and D. M. Fliss. 1997. Bacteriologic response to oral cephalosporins. Are established susceptibility breakpoints appropriate in the case of acute otitis media. J. Infect. Dis. 176:1253-1259.
15. Ednie, L. M., M. A. Visalli, M. R. Jacobs, and P. C. Appelbaum. 1996. Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. Antimicrob. Agents Chemother. 40:1950-1952.
16. Fasola, E. L., S. Bajaksouzian, P. C. Appelbaum, and M. R. Jacobs. 1997. Variation in erythromycin and clindamycin susceptibilities of Streptococcus pneumoniae by four test methods. Antimicrob. Agents Chemother. 41:129-134.
17. Foulds, G., R. M. Shepard, and R. B. Johnson. 1990. The pharmacokinetics of azithromycin in human serum and tissues. J. Antimicrob. Chemother. 25(Suppl. A):73-82.
18. Geslin, P., A. Buu-Hoï, A. Frémaux, and J. F. Acar. 1992. Antimicrobial resistance in Streptococcus pneumoniae: an epidemiological survey in France, 1970-1990. Clin. Infect. Dis. 15:95-98.
19. Girard, A. E., C. R. Cimochowski, and J. A. Faiella. 1996. Correlation of increased azithromycin concentrations with phagocyte infiltration into sites of localized infection. J. Antimicrob. Chemother. 37(Suppl. C):9-19.
20. Gladue, R. P., G. M. Bright, R. E. Isaacson, and M. F. Newborg. 1989. In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob. Agents Chemother. 33:277-282.
21. Goldbart, A., P. Yagupsky, N. Markus, D. Fraser, and R. Dagan. 1997. Prevalence of antimicrobial resistance among pneumococcal isolates from children with otitis media in southern Israel. Pediatr. Infect. Dis. J. 16:521-523.
22. Hoberman, A., J. L. Paradise, D. J. Burch, W. A. Valinski, J. A. Hedrick, G. H. Aronovitz, M. A. Drehobl, and J. A. Rogers. 1997. Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin/clavulanate potassium (Augmentin®) for treatment of acute otitis media in children. Pediatr. Infect. Dis. J. 16:463-470.
23. Howie, V. M., and J. H. Ploussard. 1969. The "in vivo sensitivity test" - bacteriology of middle ear exudate. Pediatrics 44:940-944.
24. Howie, V. M., and J. H. Ploussard. 1972. Efficacy of fixed combination antibiotics versus separate components in otitis media. Clin. Pediatr. 11:205-214.
25. Howie, V. M., and M. J. Owen. 1987. Bacteriologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Pediatr. Infect. Dis. J. 6:989-991.
26. Howie, V. M., R. Dillard, and B. Lawrence. 1985. In vivo sensitivity test in otitis media: efficacy of antibiotics. Pediatrics 75:8-13.
27. Howie, V. M. 1992. Eradication of bacterial pathogens from middle ear infection. Clin. Infect. Dis. 14(Suppl. 2):209-210.
28. Jackson, M. A., S. Shelton, J. D. Nelson, and G. H. McCracken. 1984. Relatively penicillin-resistant pneumococcal infections in pediatric patients. Pediatr. Infect. Dis. J. 3:129-132.
29. Kam, K. M., K. Y. Luey, S. M. Fung, P. P. Yiu, T. J. Harden, and M. M. Cheung. 1995. Emergence of multiple-antibiotic-resistant Streptococcus pneumoniae in Hong Kong. Antimicrob. Agents Chemother. 39:2667-2670.
30. Khurana, C. M. 1996. A multicenter, randomized, open label comparison of azithromycin and amoxicillin/clavulanate in acute otitis media among children attending day care or school. Pediatr. Infect. Dis. J. 15:S24-S29.
31. Klugman, K. P. 1990. Pneumococcal resistance to antibiotics. Clin. Microbiol. Rev. 3:171-196.
32. Leibovitz, E., L. Piglansky, S. Raiz, D. Greenberg, P. Yagupsky, J. Press, D. M. Fliss, A. Leiberman, and R. Dagan. 1998. Bacteriologic efficacy of a three-day intramuscular ceftriaxone regimen in nonresponsive acute otitis media. Pediatr. Infect. Dis. J. 17:1126-1131.
33. Leibovitz, E., S. Raiz, L. Piglansky, D. Greenberg, P. Yagupsky, D. M. Fliss, and A. Leiberman. 1998. Resistance pattern of middle ear fluid isolates in acute otitis media recently treated with antibiotics. Pediatr. Infect. Dis. J. 17:463-469.
34. Marchant, C. D., P. A. Shurin, V. A. Turczyk, J. C. Feinstein, C. E. Johnson, D. E. Wasikowski, L. J. Knapp, and M. A. Tutihasi. 1984. A randomized controlled trial of cefaclor compared with trimethoprim-sulfamethoxazole for treatment of acute otitis media. J. Pediatr. 105:633-638.
35. Marchant, C. D., S. A. Carlin, C. E. Johnson, and P. A. Shurin. 1992. Measuring the comparative efficacy of antibacterial agents for acute otitis media; the "Polyanna phenomenon." J. Pediatr. 120:72-77.
36. McCarty, J. 1996. A multicenter, open label trial of azithromycin for the treatment of children with acute otitis media. Pediatr. Infect. Dis. J. 15:S10-S14.
37. McLinn, S. E. 1980. Cefaclor in treatment of otitis media and pharyngitis in children. Am. J. Dis. Child. 134:560-563.
38. National Committee for Clinical Laboratory Standards. 1995. Performance standards for antimicrobial susceptibility testing: sixth informed supplement, vol. 15, no. 14. Document M100-S6. National Committee for Clinical Laboratory Standards, Wayne, Pa.
39. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
40. Owen, M. J., R. Anwar, H. K., Nguyen, P. R. Swank, E. R. Bannister, and V. M. Howie. 1993. Efficacy of cefixime in the treatment of acute otitis media in children. Am. J. Dis. Child. 147:81-86.
41. Patel, J. A., B. Reisner, N. Vizirinia, M. Owen, T. Chonmaitree, and V. Howie. 1995. Bacteriologic failure of amoxicillin-clavulanate in treatment of acute otitis media caused by nontypeable Haemophilus influenzae. J. Pediatr. 126:799-806.
42. Pichichero, M. E., S. McLinn, G. Aronovitz, R. Fiddes, J. Blumer, K. Nelson, B. Dashefsky. 1997. Cefprozil treatment of persistent and recurrent acute otitis media. Pediatr. Infect. Dis. J. 16:471-478.
43. Piipo, T., S. Stefansson, T. Pitkäjärvi, and C. Lundberg. 1991. Double-blind comparison of cefixime and cefaclor in the treatment of acute otitis media in children. Scand. J. Infect. Dis. 23:459-465.
44. Principi, N. 1995. Multicentre comparative study of the efficacy and safety of azithromycin compared with amoxicillin/clavulanic acid in the treatment of paediatric patients with otitis media. Eur. J. Clin. Microbiol. Infect. Dis. 14:669-676.
45. Reed, M. D., and J. L. Blumer. 1997. Azithromycin: a critical review of the first azilide antibiotic and its role in pediatric practice. Pediatr. Infect. Dis. J. 16:1069-1083.
46. Rodriguez, A. F. 1996. An open study to compare azithromycin with cefaclor in the treatment of children with acute otitis media. J. Antimicrob. Chemother. 37(Suppl. C):63-69.
47. Scaglione, F. 1997. Predicting the clinical efficacy of antibiotics: toward definitive criteria. Pediatr. Infect. Dis. J. 16:S56-S59.
48. Schreiber, J. R., and M. R. Jacobs. 1995. Antibiotic-resistant pneumococci. Pediatr. Clin. N. Am. 42:519-537.
49. Spika, J. S., R. R. Facklam, B. D. Plikaytis, M. J. Oxtboy, and the Pneumococcal Surveillance Working Group. 1991. Antimicrobial resistance of Streptococcus pneumoniae in the United States. 1973-1987. J. Infect. Dis. 163: 1273-1278.
50. Sutcliffe, J., T. Grebe, A. Tait-Kamradt, and L. Wondrack. 1996. Detection of erythromycin resistant determinants by PCR. Antimicrob. Agents Chemother. 40:2562-2566.