A multicenter, double blind comparison of azithromycin and amoxicillin/clavulanate for the treatment of acute otitis media in children

Pediatric Infectious Disease Journal

Volumn 15, Issue 9 SUPPL., 1996, Pages

  McLinn, Samuel ^a  

^a Scottsdale Pediatric Center   (United States)

Author keywords

amoxicillin clavulanate; azithromycin; otitis media; Pediatric

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AZITHROMYCIN;

ADOLESCENT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NEUROTOXICITY; OTITIS MEDIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN TOXICITY; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; AMOXICILLIN; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CHILD; CHILD, PRESCHOOL; CLAVULANIC ACIDS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HUMANS; INFANT; OTITIS MEDIA;

EID: 0029791058     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-199609000-00001     Document Type: Article

References (20)

1. Hopkins S. Clinical safety and tolerance of azithromycin in children. J Antimicrob Chemother 1993;31(Suppl E):111-7.
2. Retsema J, Girard A, Schelkly W, et al. Spectrum and mode of action of azithromycin (CP-62 993), a new 15-membered-ring macrolide with improved potency against Gram-negative organisms. Antimicrob Agents Chemother 1987;31:1939-47.
3. Dunkin KT, Jones S, Howard AJ. The in-vitro activity of CP-62 993 against Haemophilus influenzae, Branhamella catarrhalis, staphylococci and streptococci. J Antimicrob Chemother 1988;21:405-11.
4. Dark D. Multicenter evaluation of azithromycin and cefaclor in acute lower respiratory tract infections. Am J Med 1991; 91(Suppl 3A):31S-35S.
5. Hooton TM. A comparison of azithromycin and penicillin V for the treatment of streptococcal pharyngitis. Am J Med 1991;91(Suppl 3A):23S-26S.
6. Kinasewitz G, Wood RG. Azithromycin versus cefaclor in the treatment of acute bacterial pneumonia. Eur J Clin Microbiol Infect Dis 1991;10:872-7.
7. Mallory SB. Azithromycin compared with cephalexin in the treatment of skin and skin structure infections. Am J Med 1991;91(Suppl 3A):36S-39S.
8. Kiani R. Double-blind, double-dummy comparison of azithromycin and cephalexin in the treatment of skin and skin structure infections. Eur J Clin Microbiol Infect Dis 1991;10:880-4.
9. Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990;25(Suppl A):73-82.
10. Retsema JA, Bergeron JM, Girard D, Milisen WB, Girard AE. Preferential concentration of azithromycin in an infected mouse thigh model. J Antimicrob Chemother 1993;31(Suppl E):5-16.
11. Nahata MC, Koranyi KI, Gadgil SD, Hilligoss DM, Fouda HG, Gardner MJ. Pharmacokinetics of azithromycin in pediatric patients after oral administration of multiple doses of suspension. Antimicrob Agents Chemother 1993;37:314-6.
12. Mohs E, Rodriguez-Solares A, Rivas E, El Hoshy Z. A comparative study of azithromycin and amoxycillin in paediatric patients with acute otitis media. J Antimicrob Chemother 1993;31(Suppl E):73-9.
13. Manfredi R, Jannuzzi C, Mantero E, et al. Clinical comparative study of azithromycin versus erythromycin in the treatment of acute respiratory tract infections in children. J Chemother 1992;4:364-70.
14. Pestalozza G, Cioce C, Facchini M. Azithromycin in upper respiratory tract infections: a clinical trial in children with otitis media. Scand J Infect Dis Suppl 1992;83:22-5.
15. Schaad UB. Multicentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children. J Antimicrob Chemother 1993;31(Suppl E):81-8.
16. Daniel RR. Comparison of azithromycin and co-amoxiclav in the treatment of otitis media in children. J Antimicrob Chemother 1993;31(Suppl E):65-71.
17. Bergman AB, Werner RJ. Failure of children to receive penicillin by mouth. N Engl J Med 1963;268:1334-8.
18. Cockburn J, Gibberd RW, Reid AL, Sanson-Fisher RW. Determinants of non-compliance with short term antibiotic regimens. Br Med J 1987;295:814-8.
19. Khurana CM. A multicenter, randomized, open label comparison of azithromycin and amoxicillin/clavulanate in acute otitis media among children attending day care or school. Pediatr Infect Dis J 1996;15:S24-9.
20. Powers JL. Properties of azithromycin that enhance the potential for compliance in children with upper respiratory tract infections. Pediatr Infect Dis J 1996;15:S30-7.