Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis

BMJ

Volumn 314, Issue 7093, 1997, Pages 1526-

  Del Mar, Christopher B ^a   Glasziou, Paul ^a   Hayem, Mauricio ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADOLESCENT; ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIARRHEA; DRUG EFFICACY; HEARING IMPAIRMENT; HUMAN; INFANT; META ANALYSIS; METHODOLOGY; OTITIS MEDIA; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT INFECTION; RISK; SYMPTOM; VOMITING;

ACUTE DISEASE; ADOLESCENT; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; DEAFNESS; DECISION MAKING; HUMANS; INFANT; OTITIS MEDIA; PAIN; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 0030949052     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.314.7093.1526     Document Type: Article

References (20)

1. Klein J. Epidemiology of acute otitis media. Infect Dis 1989; 8(suppl 1):89.
2. Berman S. Otitis media in developing countries. Pediatrics 1995; 96: 126–131.
3. Rudberg R. Sulfonamide and penicillin in acute otitis media. Acta Oto Laryngol 1954; 44 suppl: 45–65.
4. Rosenfeld RM, Vertrees JE, Carr J, Cipolle RJ, Uden DL, Giebink G, et al. Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials. J Pediatr 1994; 124: 335–367.
5. Ruuskanen O, Arola M, Heikkinen T, Ziegler T. Viruses in acute otitis media: increasing evidence for clinical significance. Pediatr Infect Dis J 1991; 10: 425–427.
6. Froom J, Culpepper L, Grob P, Bartelds A, Bowers P, Bridges Webb C, et al. Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. BMJ 1990; 300: 582–586.
7. Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. BMJ 1994; 309: 1286–1291.
8. Chalmers I, Adams M, Dickersin K, Hetherington J, Tarnow-Mordi W, Meinert C, et al. A cohort study of summary reports of controlled trials. JAMA 1990; 263: 1401–1405.
9. Van Buchem FL, Dunk JHM, van't Hof MA. Therapy of acute otitis media: myringotomy, antibiotics or neither? A double-blind study in children. Lancet 1981; 2: 883–887.
10. Howie VM, Ploussard JH. Efficacy of fixed combination antibiotics versus separate components in otitis media: effectiveness of erythromycin estolate, triple sulfonamide, ampicillin, erythromycin estolate-triple sulfonamide, and placebo in 280 patients with acute otitis media under two and one-half years of age. Clin Pediatr 1972; 11: 205–214.
11. Laxdal OE, Merida J, Jones RHT. Treatment of acute otitis media: a controlled study of 142 children. Can Med Assoc J 1970; 192: 263–268.
12. Burke P, Bain J, Robinson D, Dunleavey J. Acute red ear in children: controlled trial of non-antibiotic treatment in general practice. BMJ 1991; 303: 558–562.
13. Thalin A, Densert O, Larsson A, Lyden E, Torvald R. Is penicillin necessary in the treatment of acute otitis media? In: Proceedings of the international conference on acute and secretory otitis media part 1, Jerusalem, Israel 17-22 November. Amsterdam: Kugler Publications, 1985: 441–446.
14. Kaleida PH, Casselhrant ML, Rockette HE, Paradise JL, Bluestone CD, Blatter MM, et al. Amoxicillin or myringotomy or both for acute otitis media: results of a randomized clinical trial. Pediatrics 1991; 87: 466–474.
15. Mygind N, Meistrup-Larsen K-I, Thomsen J, Thomsen VF, Josefsson K, Sorensen H. Penicillin in acute otitis media: a double-blind placebo-controlled trial. Clin Otolaryngol 1981; 6: 5–13.
16. Halsted C, Lepow ML, Balassanian N, Emmerich J, Wolinsky E. Otitis media. Clinical observation, microbiology and evaluation of therapy. Am J Dis Child 1968; 115: 542–551.
17. Claessen JQ, Appelman CL, Touw Otten FW, De Melker RA, Hordijk GJ. A review of clinical trials regarding treatment of acute otitis media. Clin Otolaryngol 1992; 17: 251–257.
18. Van Balen FAM, de Melker RA, Touw Otten FWMM. Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice. Lancet 1996; 348: 713–716.
19. Van Buchem FL, Peeters MF, van't Hof MA. Acute otitis media: a new treatment strategy. BMJ 1985; 290: 1033–1037.
20. Van Buchem FL. Antibiotics for otitis media. J R Coll Gen Pract 1987; 37: 367.