Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome

Pediatric Infectious Disease Journal

Volumn 17, Issue 9, 1998, Pages 776-782

  Dagan, Ron ^a   Leibovitz, Eugene ^a   Greenberg, David ^a   Yagupsky, Pablo ^b   Fliss, Dan M ^a   Leiberman, Alberto ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b NONE

Author keywords

Acute otitis media; Bacteriologic outcome; Clinical outcome

Indexed keywords

AMPICILLIN; AZITHROMYCIN; CEFACLOR;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM CULTURE; BODY TEMPERATURE; CONTROLLED STUDY; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; INFANT; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MORAXELLA CATARRHALIS; MYRINGOTOMY; ORAL DRUG ADMINISTRATION; OTITIS MEDIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; STREPTOCOCCUS PNEUMONIAE; TREATMENT FAILURE; TREATMENT OUTCOME;

ACUTE DISEASE; AMOXICILLIN; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BACTERIA; CEFACLOR; CEPHALOSPORINS; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; OTITIS MEDIA WITH EFFUSION; PENICILLINS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0031692669     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-199809000-00005     Document Type: Article

References (36)

1. Feigin RD, Kline MW, Hyatt SR, Ford KL III. Otitis media. In: Feigin RD, Cherry JD, eds. Textbook of pediatric infectious diseases. 3rd ed. Philadelphia: Saunders, 1992:174-89.
2. Berman S, Byrns PJ, Bondy J, Smith PJ, Lezotte D. Otitis media-related antibiotic prescribing patterns, outcomes, and expenditures in a pediatric Medicaid population. Pediatrics 1997;100:585-92.
3. Wright P. Indication and duration of antimicrobial agents for acute otitis media. Pediatr Ann 1984;13:377-9.
4. Maxson S, Yamauchi T. Acute otitis media. Pediatr Rev 1996;17:191-6.
5. Berman S. Otitis media in children. N Engl J Med 1995;332: 1560-5.
6. Arason VA, Kristinsson RG, Sigurdsson JA, Stefansdottir G, Mölstad S, Gudmunsson S. Do antimicrobials increase the carriage rate of penicillin resistant pneumococci in children? Cross sectional prevalence study. Br Med J 1996;313:387-91.
7. Seppälä H, Klukka T, Vuopio-Varkilm J, et al. The effect of changes in the consumption of macrolide antibiotics on the erythromycin resistance in group A streptococci in Finland. N Engl J Med 1997;337:441-6.
8. Cohen ML. Epidemiology of drug resistance: implication for a post-antimicrobial era. Science 1992;257:1050-5.
9. Gold HS, Moellering RC Jr. Antimicrobial-drug resistance. N Engl J Med 1996;33:1445-53.
10. Del Mar C, Glasziou P, Hayem M. Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis. Br Med J 1997;314:1526-9.
11. Majeed A, Harris T. Acute otitis media in children: fewer children should be treated with antibiotics. Br Med J 1997; 315:321-2.
12. Van Buchem FL, Peeters MF, van't Hof MA. Acute otitis media: a new treatment strategy. Br Med J 1985;290:1033-7.
13. Carlin SA, Marchant CD, Shurin PA, Johnson CE, Super DM, Rehmus JM. Host factors and early therapeutic response in acute otitis media. J Pediatr 1991;118:178-83.
14. Marchant CD, Carlin SA, Johnson CE, Shurin PA. Measuring the comparative efficacy of antibacterial agents for acute otitis media: The "Pollyanna phenomenon." J Pediatr 1992; 120:72-7.
15. Kaleida PH, Casselbrandt ML, Rockette HE, et al. Amoxicillin or myringotomy or both for acute otitis media: results of a randomized clinical trial. Pediatrics 1991;87:466-74.
16. Burke P, Bain J, Robinson D, Dunleavey J. Acute red ear in children: controlled trial of non antibiotic treatment in general practice. Br Med J 1991;303:558-62.
17. Craig WA, Andes D. Pharmacokinetics and pharmacodynamics of antibiotics in otitis media. Pediatr Infect Dis J 1996;15: 255-9.
18. Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins. Diagn Microbiol Infect Dis 1995;22:89-96.
19. Urban A, Andes D, Craig WA. In vivo activity of cefpodoxime against penicillin-resistant pneumococci [Abstract 2229]. Presented at the 19th International Congress of Chemotherapy, Montreal, Canada, July 16 to 25, 1995.
20. Andes D, Urban A, Craig WA. In vivo activity of amoxicillin and amoxicillin-clavulanate against penicillin-resistant pneumococci [Abstract A82]. In: Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 17 to 20, 1995. Washington, DC: American Society for Microbiology, 1995:16.
21. Klein JO. Microbiologic efficacy of antibacterial drugs for acute otitis media. Pediatr Infect Dis J 1993;12:973-5.
22. Dagan R, Fliss DM, Leibovitz E, et al. Antibiotic treatment in acute otitis media: "in vivo" demonstration of antibacterial activity. Clin Microbiol Infect 1997;3(Suppl 3):43-8.
23. Dagan R, Abramson O, Leibovitz E, et al. Impaired bacteriologic response to oral cephalosporins in acute otitis media caused by pneumococci with intermediate resistance to penicillin. Pediatr Infect Dis J 1996;15:980-5.
24. Dagan R, Abramson O, Leibovitz E, et al. Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media? J Infect Dis 1997;176:1253-9.
25. Leibovitz E, Abramson O, Greenberg D, et al. Correlation between minimum inhibitory concentration values and bacteriologic outcome in pneumococcal acute otitis media [Abstract LM59]. In: Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, September 15 to 18, 1996. Washington, DC: American Society for Microbiology, 1996.
26. Leibovitz E, Piglansky L, Raiz S, et al. Bacteriologic efficacy of a 3-day intramuscular ceftriaxone (CRO) in nonresponsive acute otitis media (NR-AOM) [Abstract K-105]. In: Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario, Canada, September 28 to October 1, 1997. Washington, DC: American Society for Microbiology, 1997.
27. Dagan R, Piglansky L, Yagupsky P, Fliss DM, Leiberman A, Leibovitz E. Bacteriologic response in acute otitis media: comparison between azythromycin, cefaclor and amoxicillin [Abstract K-103]. In: 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, Toronto, Ontario, Canada, September 28 to October 1, 1997. Washington, DC: American Society for Microbiology, 1997.
28. Howie VM, Owen MJ. Bacteremiologic and clinical efficacy of cefixime compared with amoxicillin in acute otitis media. Pediatr Infect Dis J 1987;6:989-91.
29. Johnson CE, Carlin SA, Super DM, et al. Cefixime compared with amoxicillin for treatment of acute otitis media. J Pediatr 1991;119:117-22.
30. Giebink G, Batalden P, Russ J, Chap T. Cefaclor versus amoxicillin in treatment of acute otitis media. Am J Dis Child 1984;138:287-92.
31. Harsten G, Prellen K, Heldrup J, Kalm O, Kornfalt R. Treatment failure in acute otitis media. Acta Otolaryngol (Stockh) 1989;108:253-8.
32. Hoberman A, Paradise JL, Burch DJ, et al. Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin/clavulanate potassium (Augmentin®) for treatment of acute otitis media in children. Pediatr Infect Dis J 1997;16:463-70.
33. Pichichero MB, McLinn S, Aronovitz G, et al. Cefprozil treatment of persistent and recurrent acute otitis media. Pediatr Infect Dis J 1997;16:471-8.
34. Shurin P, Pelton S, Donner A, Klein J. Persistence of middle ear effusion after acute otitis media in children. N Engl J Med 1979;300:1121-3.
35. Froom J, Culpepper L, de Melker RA, et al. Antimicrobials for acute otitis media? A review from the International Primary Care Network. Br Med J 1997;315:98-102.
36. Culpepper L, Froom J. Routine antimicrobial treatment for acute otitis media: is it necessary? JAMA 1997;278:1643-5.