Intrinsic defects, in macrophage IL-12 production associated with immune dysfunction in the MRL/++ and New Zealand black/white F1 lupus-prone mice and the Leishmania major-susceptible BALB/c strain

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6878-6884

  Alleva, David G ^a,c   Kaser, Steven B ^c   Beller, David I ^b,c  

^a NEUROCRINE BIOSCIENCES INC   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 6; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DISEASE PREDISPOSITION; IMMUNOREGULATION; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CELLS, CULTURED; CROSSES, GENETIC; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-6; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED NZB; MICE, INBRED STRAINS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; TH1 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032534683     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Elson, C. J., R. N. Barker, S. J. Thompson, and N. A. Williams. 1995. Immunologically ignorant autoreactive T sells, epitope spreading and repertoire limitation. Immunol. Today 16:71.
2. Klinman, D. M., and A. D. Steinberg. 1995. Inquiry into murine and human lupus. Immunol. Rev. 144:157.
3. Cohen, P. L., and R. A. Eisenberg. 1991. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9:243.
4. Nagata, S., and T. Suda. 1995. Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16:39.
5. Jyonouchi, H., and P. W. Kincais. 1984. Precocious and enhanced functional maturation of B lineage cells in New Zealand Black mice during embryonic development. J. Exp. Med. 159:1277.
6. 1 Pre-B cells. J. Exp. Med. 176:1343.
7. Prud'homme, G. J., R. S. Balderas, F. J. Dixon, and A. N. Theofilopoulos. 1983. B cell dependence on and response to accessory signals in murine lupus strains. J. Exp. Med. 157:1815.
8. Hartwell, D., J. Levine, M. Fenton, C. Francis, C. Leslie, and D. Beller. 1994. Cytokine dysregulation and the initiation of systemic autoimmunity. Immunol. Lett. 43:15.
9. Donnelly, R. P., J. Levine, D. W. Hartwell, G. Frendl, M. J. Fenton, and D. I. Beller. 1990. Aberrant regulation of IL-1 expression in macrophages from young autoimmune-prone mice. J. Immunol. 145:3231.
10. Levine, J., B. J. Pugh, D. Hartwell, J. M. Fitzpatrick, A. Marshak-Rothstein, and D. I. Beller. 1993. Interleukin-1 dysregulation is an intrinsic defect in macrophages from MRL autoimmune-prone mice. Eur. J. Immunol. 23:2951.
11. Dang-Vu, A., D. S. Pisetsky, and J. B. Weinberg. 1987. Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. J. Immunol. 138:1757.
12. Jacob, C. O., and H. McDevitt. 1988. Tumour necrosis factor-α in murine autoimmune lupus nephritis. Nature 331:356.
13. Russel, P. J., and F. H. Cameron. 1986. Studies on macrophage function in murine Lupus erythematosus. Ill. The nature, anatomical location, and reversibility of the phagocytic defect. J. Leukocyte Biol. 39:49.
14. Kofler, R., R. D. Schreiber, F. J. Dixon, and A. N. Theofilopoulos. 1987. Macrophage I-A/I-E expression and macrophage stimulating lymphokines in murine lupus. Cell. Immunol. 87:92.
15. 1 lupus-prone mice. J. Immunol. 159:5610.
16. Trinchieri, G. 1995. Interleukin 12: a proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
17. Trembleau, S., T. Germann, M. K. Gately, and L. Adorini. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
18. Hogquist, K. A., E. R. Unanue, and D. D. Chaplin. 1991. Release of IL-1 from mononuclear phagocytes. J. Immunol. 147:2181.
19. Espevik, T., and J. Nissen-Meyer. 1986. A highly sensitive cell line, WEHI-164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods 95:99.
20. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
21. Levine, J., D. Hartwell, and D. I. Beller. 1991. Imbalanced cytokine production by macrophages from autoimmune mice. Immunol. Lett. 30:183.
22. Morel, L., C. Mohan, Y. Yu, B. P. Croker, N. Tian, A. Deng, and E. K. Wakeland. 1997. Functional dissection of systemic lupus erythematosus using congenic mouse strains. J. Immunol. 158:6019.
23. Vyse, T. J., L. Morel, F. J. Tanner, E. K. Wakeland, and B. Kotzin. 1996. Backcross analysis of genes linked to autoantibody production in New Zealand white mice. J. Immunol. 157:2719.
24. Rudofsky, M. L., U. H. Longmatc, J. A. Schiffenbauer, and E. K. Wakeland. 1994. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1:219.
25. Theofilopoulos, A. N. 1995. The basis of autoimmunity: part I. Immunol. Today 16:90.
26. Theofilopoulos, A. N. 1995. The basis of autoimmunity: part II. Immunol. Today 16:150.
27. Dinarello, C. A. 1991. Inflammatory cytokines: interleukin-1 and tumor necrosis factor as effector molecules in autoimmune diseases. Curr. Opin. Immunol. 3:941.
28. 1 mice. Clin. Immunol. Immunopathol. 52:421.
29. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15:749.
30. Fiorentino, D. F., A. Zlotnik, T.R. Mosmann, M. H. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815.
31. Schindler, R., P. Ghezzi, and C. A. Dinarello. 1990. IL-1 induces IL-1. IV. IFN-γ suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1. J. Immunol. 144:2216.
32. Bach, E. A., M. Aguet, and R. D. Schreiber. 1997. The IFN-γ receptor. Annu. Rev. Immunol. 15:563.
33. Fultz, M. J., S. A. Barber, C. W. Dieffenbach, and S. N. Vogel. 1993. Induction of IFN-γ in macrophages by lipopolysaccharide. Int. Immunol. 5:1383.
34. + B (B-1) cells and immunity. In Handbook of B and T lymphocytes, Chapter 17. Academic Press, Orlando, FL, p. 421.
35. Skeen, M. J., and H. K. Ziegler. 1995. Activation of γδ T cells for production of IFN-γ is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J. Immunol. 154:5832.
36. Young, H. A., and K. J. Hardy. Role of interferon-γ in immune cell regulation. J. Leukocyte Biol. 58:373.
37. Bagenstose, L. M., P. Salgame, and M. Monestier. 1998. IL-12 down-regulates autoantibody production in mercury-induced autoimmunity. J. Immunol. 160:1612.
38. Houssiau, F. A., F. Mascart-Lemone, M. Stevens, M. Libin, J. P. Devogelaer, M. Goldman, and J. C. Renauld. 1997. IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC). Clin. Exp. Immunol. 108:375.
39. Liu, T. F., and B. M. Jones. 1998. Impaired production of IL-12 in systemic lupus erythematosus. I. Excessive production of IL-10 suppresses production of IL-12 by monocytes. Cytokine 10:140.
40. Liu, T. F., and B. M. Jones. 1998. Impaired production of IL-12 in system lupus erythematosus. II. IL-12 production in vitro is correlated negatively with serum IL-10, positively with serum IFN-γ and negatively with disease activity in SLE. Cytokine 10:148.
41. Shibuya, K., D. Robinson, F. Zonin, S. B. Hartley, S. E. Macatonia, C. Somoza, C. A. Hunter, K. M. Murphy, and A. O'Garra. 1998. IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice. J. Immunol. 160:1708.
42. Roberts, M., B. A. Mock, and J. M. Blackwell. 1993. Mapping of genes controlling Leishmania major infection in CXS recombinant inbred mice. Eur. J. Immunogenet. 20:349.