CD8+ lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule Mamu-A*01: Implications for vaccine design and testing

Journal of Virology

Volumn 75, Issue 2, 2001, Pages 738-749

  Allen, T M ^a   Mothe B R ^a   Sidney, J ^a   Jing, P ^a   Dzuris, J L ^a   Liebl, M E ^a   Vogel, T U ^a   O'Connor, D H ^a   Wang, X ^a   Wussow, M C ^a   Thomson, J A ^a   Altman, J D ^a   Watkins, D I ^a   Sette, A ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; EPITOPE GAG CM9; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1 MAMU A 01; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN IMMUNODEFICIENCY VIRUS; SUPPRESSOR CELL; VIRUS INFECTION;

AIDS VACCINES; AMINO ACID SEQUENCE; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; MACACA MULATTA; MOLECULAR SEQUENCE DATA; PEPTIDES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0035164653     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.2.738-749.2001     Document Type: Article

References (78)

1. Derivation of HLA-A11/Kb transgenic mice: Functional CTL repertoire and recognition of human A11-restricted CTL epitopes
2. Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus
3. Induction of AIDS virus-specific CTL activity in fresh, unstimulated PBL from rhesus macaques vaccinated with a DNA prime/MVA boost regimen
4. SIV and SHIV CTL epitopes identified in macaques
5. Phenotypic analysis of antigen-specific T lymphocytes
6. MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies
7. Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis
8. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
9. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
10. The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primates
11. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
12. Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses
13. Analysis of a successful immune response against hepatitis C virus
14. + responses in HIV type 1-infected patients: Comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy
15. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
16. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques
17. Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers
18. MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL
19. Vaccine protection against simian immunodeficiency virus infection
20. Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles
21. Conserved MHC class I peptide binding motif between humans and rhesus macaques
22. + cytotoxic T lymphocytes specific for dominant and nondominant viral epitopes in simian-human immunodeficiency virus-infected rhesus monkeys
23. Virus-specific CTL responses select for amino acid variation in SIV Env and Nef
24. Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses
25. The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A*01 class I molecule
26. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
27. 131I-labeled human growth hormone of high specific radioactivity
28. Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques using a DNA prime-modified vaccinia virus Ankara boost vaccination regimen
29. Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine
30. Identification of a novel HLA-A24-restricted cytotoxic T-lymphocyte epitope derived from HIV-1 Gag protein
31. Nucleotide sequences, polymorphism and gene deletion of T cell receptor beta-chain constant regions of Pan troglodytes and Macaca mulatta
32. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques
33. Macaque models for AIDS vaccine development
34. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
35. Comparative biology of natural and experimental SIVmac infection in macaque monkeys: A review
36. Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes
37. ELISPOT assay to detect cytokine-secreting murine and human cells
38. A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing
39. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
40. Role of preimmunization virus sequences in cellular immunity in HIV-infected patients during HIV type 1 MN recombinant gp160 immunization
41. Analysis of gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I peptide complex
42. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
43. Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
44. Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys
45. Selection of virus variants and emergence of virus escape mutants after immunization with an epitope vaccine
46. Protection against lethal simian immunodeficiency virus SIVsmmPBj14 disease by a recombinant Semliki Forest virus gp160 vaccine and by a gp120 subunit vaccine
47. A formalin-inactivated whole SIV vaccine confers protection in macaques
48. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection
49. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
50. Pathogenesis of SIVmac251 after atraumatic inoculation of the rectal mucosa in rhesus monkeys
51. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
52. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis
53. Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques
54. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
55. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi
56. Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules
57. Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: Recognition of autologous virus sequences within a conserved immunodominant epitope
58. Control of viremia in simian immunodeficiency virus infection by CD8(+) lymphocytes
59. Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays
60. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes
61. Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leukocyte antigen B35 molecules
62. Measurement of MHC/peptide interactions by gel filtration
63. Evolutionary stability of transspecies major histocompatibility complex class II DRB lineages in humans and rhesus monkeys
64. Selective pressure exerted by immunodominant HIV-1-specific cytotoxic T lymphocyte responses during primary infection drives genetic variation restricted to the cognate epitope
65. Assessing animal models of AIDS
66. Evidence of presentation of multiple HIV-1 cytotoxic T lymphocyte epitopes by HLA-B*3501 molecules that are associated with the accelerated progression of AIDS
67. Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101 molecules
68. Selective amplification of simian immunodeficiency virus genotypes after intrarectal inoculation of rhesus monkeys
69. A cytotoxic T lymphocyte inhibits acquired immunodeficiency syndrome virus replication in peripheral blood lymphocytes
70. Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice
71. Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex
72. Immunodominance analysis of CTL responses to influenza PR8 virus reveals two new dominant and subdominant Kb-restricted epitopes
73. Rapid screening for Mamu-A1-positive rhesus macaques using a SIVmac Gag peptide-specific cytotoxic T-lymphocyte assay
74. Cytotoxic T lymphocytes against HIV
75. CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication
76. MHC of nonhuman primates
77. + cytotoxic T-cell epitopes
78. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses