Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice

Molecular Biology of the Cell

Volumn 12, Issue 6, 2001, Pages 1557-1568

  Reichelt, J ^a   Bussow H ^a   Grund, C ^a   Magin, T M ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 14; KERATIN; KERATIN 10; KERATIN 5; KERATOHYALIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CYTOSKELETON; ELECTRON MICROSCOPY; EPIDERMIS; GENODERMATOSIS; IMMUNOFLUORESCENCE; MOUSE; MULTIGENE FAMILY; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STABILITY; WOUND HEALING;

EID: 0035163065     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.6.1557     Document Type: Article

References (61)

1. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
2. A keratin 14 "knockout" mutation in recessive epidermolysis bullosa simplex resulting in less severe disease
3. A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis
4. Schwann cell myelin ensheathing CNS axons in the nerve fiber layer of the cat retina
5. A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases
6. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis
7. A human keratin 14 "knockout": The absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein
8. The genetic basis of epidermolytic hyperkeratosis: A disorder of differentiation-specific epidermal keratin genes
9. Human keratin diseases: Hereditary fragility of specific epithelial tissues
10. Towards a molecular definition of keratinocyte activation after acute injury to stratified epithelia
11. Elucidating the early stages of keratin filament assembly
12. Assembly of stratum corneum basic protein and keratin filaments in macrofibrils
13. Intermediate filament associated protein of epidermis
14. Pathogenesis of two axonopathies does not require axonal neurofilaments
15. Isolation and symmetrical splitting of desmosomal structures in 9 M urea
16. Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis
17. Changes in keratin gene expression during terminal differentiation of the keratinocyte
18. Intermediate filaments: Structure, dynamics, function, and disease
19. Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding
20. Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration
21. Histidine-rich proteins (filaggrins): Structural and functional heterogeneity during epidermal differentiation
22. Patterned acquisition of skin barrier function during development
23. Pair formation and promiscuity of cytokeratins: Formation in vitro of heterotypic complexes and intermediate-sized filaments by homologous and heterologous recombinations of purified polypeptides
24. Characterization of an epidermal phosphatase specific for filaggrin phosphorylated by casein kinase II
25. Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality
26. Functional differences between keratins of stratified and simple epithelia
27. Filaggrin expression in epidermolytic ichthyosis (epidermolytic hyperkeratosis)
28. Effects of keratin 14 ablation on the clinical and cellular phenotype in a kindred with recessive epidermolysis bullosa simplex
29. Identification of rat epidermal profilaggrin phosphatase as a member of the protein phosphatase 2A family
30. Making a connection: Direct binding between keratin intermediate filaments and desmosomal proteins
31. Apoptosis generates stable fragments of human type I keratins
32. Profilaggrin requires both linker and filaggrin peptide sequences to form granules: Implications for profilaggrin processing in vivo
33. Posttranslational regulation of keratins: Degradation of mouse and human keratins 18 and 8
34. Isolation, sequence, and expression of a human keratin K5 gene: Transcriptional regulation of keratins and insights into pairwise control
35. The basal keratin network of stratified squamous epithelia: Defining K15 function in the absence of K14
36. The mechanism of interaction of filaggrin with intermediate filaments. The ionic zipper hypothesis
37. Novel insights into intermediate-filament function from studies of transgenic and knockout mice
38. Lessons from keratin 18 knockout mice: Formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates
39. The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture
40. Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development
41. Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments
42. Binding of keratin intermediate filaments (K10) to the cornified envelope in mouse epidermis: Implications for barrier function
43. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
44. Mouse keratin 4 is necessary for internal epithelial integrity
45. Chaperone activity of alpha-crystallins modulates intermediate filament assembly
46. The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16
47. Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in EBS
48. Gene targeting at the mouse cytokeratin 10 locus: Severe skin fragility and changes of cytokeratin expression in the epidermis
49. Out of balance: Consequences of a partial keratin 10 knockout
50. Normal ultrastructure, but altered stratum corneum lipid and protein composition in a mouse model for epidermolytic hyperkeratosis
51. Identification of two intermediates during processing of profilaggrin to filaggrin in neonatal mouse epidermis
52. Identification of proteolytic cleavage sites in the conversion of profilaggrin to filaggrin in mammalian epidermis
53. Contactus adherens, a special type of plaque-bearing adhering junction containing M-cadherin, in the granule cell layer of the cerebellar glomerulus
54. Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis
55. A functional "knockout" of human keratin 14
56. Characterization of a class of cationic proteins that specifically interact with intermediate filaments
57. The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope
58. Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope
59. Cytokeratins 8 and 19 in the mouse placental development
60. Monoclonal antibody analysis of keratin expression in epidermal diseases: A 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes
61. Mutations in the H1 and 1A domains in the keratin 1 gene in epidermolytic hyperkeratosis