Profilaggrin requires both linker and filaggrin peptide sequences to form granules: Implications for profilaggrin processing in vivo

Journal of Investigative Dermatology

Volumn 112, Issue 6, 1999, Pages 843-852

  Kuechle, Melanie K ^a   Thulin, Craig D ^b   Presland, Richard B ^a   Dale, Beverly A ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Brigham Young University   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Filaggrin; Green fluorescent protein fusion protein; Keratinization; Mutagenesis

Indexed keywords

FILAGGRIN; GREEN FLUORESCENT PROTEIN; INTERMEDIATE FILAMENT PROTEIN; KERATIN; KERATOHYALIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROFILAGGRIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GRANULE; HUMAN; INTERMEDIATE FILAMENT; KERATINIZATION; KERATINOCYTE; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

EID: 0033002351     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00599.x     Document Type: Article

References (40)

1. Baden HP, Kubilus J: The growth and differentiation of cultured newborn rat keratinocytes. J Invest Dermatol 80:124-130, 1983
2. Bairoch A: The PROSITE dictionary of sites and patterns in proteins, its current status. Nucleic Acids Res 21:3007-3103, 1993
3. Braman J, Papworth C, Greener A: Site-directed mutagenesis using double-stranded plasmid DNA templates. Method Mol Biol 57:31-44, 1996
4. Compton JG, DiGiovanna JJ, Santucci SK: Linkage of epidermolytic hyperkeratosis to the type II keratin gene cluster on chromosome 12q. Nature Genet 1:301-305, 1992
5. Dale BA, Holbrook KA, Steinert PM: Assembly of stratum comeum basic protein and keratin filaments in macrofibrils. Nature 276:729-731, 1978
6. Dale BA, Gown AM, Fleckman P, Kimball JR, Resing KA: Characterization of two monoclonal antibodies to human epidermal keratohyalin: reactivity with filaggrin and related proteins. J Invest Dermatol 88:303-313, 1087
7. Dale BA, Resing KA, Haydock PV: In: Goldman RD, Steinert PM (eds). Cellular and Molecular Biology of Intermediate Filaments. NewYork: Plenum, 1990, pp. 393-412
8. Dale BA, Kimball JR, Fleckman P: CHILD syndrome: lack of expression of epidermal differentiation markers in lesional ichthyotic skin. J Invest Dermatol 98:442-449, 1992
9. Dale BA, Presland RB, Lewis SP, Underwood RA, Fleckman P: Transient expression of epidermal filaggrin in cultured cells causes collapse of intermediate filament networks with altered cell shape and nuclear integrity. J Invest Dermatol 108:179-187, 1997
10. Epstein F: Molecular genetics of epidermolysis bullosa. Science 256:799-804, 1992
11. Fleckman P, Dale BA, Holbrook KA: Profilaggrin, a high-molecular-weight precursor of filaggrin in human epidermis and cultured keratinocytes. J Invest Dermatol 85:507-512, 1985
12. Fuchs E: Genetic skin disorders of keratin. J Invest Dermatol 99:671-674, 1992
13. Gan SQ, McBride OW, Idler WW, Markova N, Steinert PM: Organization, structure, and polymorphisms of the human profilaggrin gene [erratum published in Biochemistry 30:5814, 1991] Biochemistry 29:9432-9440, 1990
14. Harding CR, Scott IR: Histidine-rich proteins (filaggrins): structural and functional heterogeneity during epidermal differentiation. J Mol Biol 170:651-673, 1983
15. Haugen-Scofield J, Resing KA, Dale BA: Characterization of an epidermal phosphatase specific for filaggrin phosphorylated by casein kinase II. J Invest Dermatol 91:533-559, 1988
16. Haydock PV, Dale BA: The repetitive structure of the profilaggrin gene as demonstrated using epidermal profilaggrin cDNA. J Biol Chem 261:12520-12525, 1986
17. Haydock PV, Dale BA: Filaggrin, an intermediate filament-associated protein: structural and functional implications from the sequence of a cDNA from rat. DNA Cell Biol 9:251-261, 1990
18. Haydock PV, Blomquist C, Brumbaugh S, Dale BA, Holbrook KA, Fleckman P: Antisense profilaggrin RNA delays and decreases profilaggrin expression and alters in vitro differentiation of rat epidermal keratinocytes. J Invest Dermatol 101:118-126, 1993
19. Kam E, Resing KA, Lim S, Dale BA: Identification of rat epidermal profilaggrin phosphatase as a member of the protein phosphatase 2A family. J Cell Sci 106:219-226, 1993
20. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
21. Lonsdale-Eccles JD, Resing KA, Meek RL, Dale BA: High-molecular-weight precursor of epidermal filaggrin and hypothesis for its tandem repeat structure. Biochemistry 23:1239-1245, 1984
22. Ludin B, Matus A: GFP illuminates the cytoskeleton. Trends Cell Biol 8:72-77, 1998
23. Mack JW, Steven AC, Steinert PM: The mechanism of interaction of filaggrin with intermediate filaments: the ionic zipper hypothesis. J Mol Biol 232:50-66, 1993
24. McKinley-Grant LJ, Idler WW, et al: Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome 1q21. Proc Natl Acad Sci USA 86:4848-4852, 1989
25. Odland GF. Structure of the skin. In: Goldsmith LA (eds). Physiology Biochemistry, Molecular Biology of the Skin. New York: Oxford University Press, 1991, pp. 3-62
26. Paladini RD, Takahashi K, Bravo NS, Coulombe PA: Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16. J Cell Biol 132:381-397, 1996
27. Patino MM, Liu JJ, Glover JR, Lindquist S: Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science 273:622-626, 1996
28. Presland RB, Bassuk JA, Kimball JR, Dale BA: Characterization of two distinct calcium binding sites in the amino terminus of human profilaggrin. J Invest Dermatol 104:218-223, 1995
29. Presland RB, Kimball JR, Kautsky MB, Lewis SP, Lo CY, Dale BA: Evidence for specific cleavage of the N-terminal domain of human profilaggrin during epidermal differentiation. J Invest Dermatol 108:170-178, 1997
30. Purkis PE, Steel JB, Mackenzie IC, Nathrath WB, Leigh IM, Lane EB: Antibody markers of basal cells in complex epithelia. J Cell Sci 97:39-50, 1990
31. Resing KA, Walsh KA, Dale BA: Identification of two intermediates during processing of profilaggrin to filaggrin in neonatal mouse epidermis. J Cell Biol 99:1372-1378, 1984
32. Resing KA, Walsh KA, Haugen-Scofield J, Dale BA: Identification of proteolytic cleavage sites in the conversion of profilaggrin to filaggrin in mammalian epidermis. J Biol Chem 264:1837-1845, 1989
33. 2+ in the second stage. J Biol Chem 268:25139-25145, 1993a
34. Resing KA, Johnson RS, Walsh KA: Characterization of protease processing sites during conversion of rat profilaggrin to filaggrin. Biochemistry 32:10036-10045, 1993b
35. Resing KA, Johnson RS, Walsh KA: Mass spectrometric analysis of 21 phosphorylation sites in the internal repeat of rat profilaggrin, precursor of an intermediate filament associated protein. Biochemistry 34:9477-9487, 1995a
36. Resing KA, Thulin C, Whiting K, Al-Alawi N, Mostad S: Characterization of profilaggrin endoproteinase I. J Biol Chem 47:28193-28198, 1995b
37. Rothnagel JA, Steinert PM: The structure of the gene for mouse filaggrin and a comparison of the repeating units. J Biol Chem 265:1862-1865, 1990
38. Smith EA, Fuchs E: Defining the interactions between intermediate filaments and desmosomes. J Cell Biol 141:1229-1241, 1998
39. Thulin CD, Walsh KA: Identification of the amino terminus of human filaggrin using differential LC/MS techniques. Implications for profilaggrin processing. Biochemistry 34:8687-8992, 1995
40. Tung YL, Resink TJ, Hemmings BA, Shenolikar S, Cohen P: The catalytic subunits of protein phosphatase 2A are distinct gene products. Eur J Biochem 138:635-641, 1984