Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function

Molecular Microbiology

Volumn 42, Issue 3, 2001, Pages 689-703

  Alrutz, Michael A ^a   Srivastava, Amit ^a   Wong, Ka Wing ^a   D'Souza Schorey, Crislyn ^b   Tang, May ^a,c   Ch'ng, Lian Ee ^a   Snapper, Scott B ^d,e   Isberg, Ralph R ^a,c  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; GUANOSINE TRIPHOSPHATE; INTEGRIN RECEPTOR; INVASIN; PROTEIN; PROTEIN ARP; RAC PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENETIC TRANSFECTION; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; YERSINIA PSEUDOTUBERCULOSIS;

3T3 CELLS; ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ACTINS; ADHESINS, BACTERIAL; ANIMALS; ANTIGENS, CD29; BACTERIAL PROTEINS; CELL LINE; CELL MEMBRANE PERMEABILITY; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOSKELETAL PROTEINS; DRUG COMBINATIONS; HUMANS; MICE; NERVE TISSUE PROTEINS; OILS; PHAGOSOMES; PHENOLS; RAC1 GTP-BINDING PROTEIN; RECEPTORS, CELL SURFACE; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL; YERSINIA PSEUDOTUBERCULOSIS; YERSINIA PSEUDOTUBERCULOSIS INFECTIONS;

BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA; YERSINIA PSEUDOTUBERCULOSIS;

EID: 0035159257     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02676.x     Document Type: Article

References (43)

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2. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
3. Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
4. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein
5. Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions
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7. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
8. Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses
9. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
10. A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated uptake into mammalian cells and promotes self-association
11. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
12. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility
13. A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
14. The cellular functions of small GTP-binding proteins
15. Crystal structure of invasin: A bacterial integrin-binding protein
16. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
17. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
18. Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
19. Multiple β 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
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21. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho
22. An aspartate residue of the Yersinia pseudotuberculosis invasin protein that is critical for integrin binding
23. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
24. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
25. Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3 process
26. The Yersinia Yops inhibit invasion of Listeria, Shigella and Edwardsiella but not Salmonella into epithelial cells
27. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
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29. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
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31. The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
32. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
33. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
34. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
35. Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells
36. N-WASP deficiency reveals distinct pathways for cell surface projections and the actin-based motility of intracellular microorganisms
37. Primary structure of an aminoglycoside 6′-N-acetyltransferase AAC(6′)-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamase
38. Bacterial internalization mediated by β 1 chain integrins is determined by ligand affinity and receptor density
39. Mutations in the cytoplasmic domain of the integrin β1 chain indicate a role for endocytosis factors in bacterial internalization
40. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells
41. GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin microfilament structure
42. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
43. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex