Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits

Current Eye Research

Volumn 18, Issue 3, 1999, Pages 240-246

  Kajikawa, Tetsu ^a   Mishima, Hiromu K ^a   Murakami, Teruo ^a   Takano, Mikihisa ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Blood aqueous barrier; P glycoprotein; Quinidine; Rabbits; Rhodamine 123

Indexed keywords

GLYCOPROTEIN P; QUINIDINE; RHODAMINE 123; RHODAMINE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; BLOOD EYE BARRIER; CAPILLARY ENDOTHELIUM; CELL STRAIN CACO 2; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PARTITION COEFFICIENT; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PUMP; RABBIT; TIGHT JUNCTION; TISSUE LEVEL; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; AQUEOUS HUMOR; BIOLOGICAL TRANSPORT; BLOOD-AQUEOUS BARRIER; CACO-2 CELLS; FLUORESCENT DYES; HUMANS; L-LACTATE DEHYDROGENASE; MALE; P-GLYCOPROTEIN; QUINIDINE; RABBITS; RHODAMINE 123;

EID: 0032904789     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.18.3.240.5365     Document Type: Article

References (26)

1. Cunha-Vaz, J. (1979) The blood-ocular barriers. Surv. Ophthalmol. 23, 279-296.
2. Bill, A. (1986) The blood-aqueous barrier. Trans. Ophthalmol. Soc. UK. 105, 149-155.
3. Ambudkar, S. V., Cardarelli, C. O., Pashinsky, I., Stein, W. D. (1997) Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. J. Biol. Chem. 272, 21160-21166.
4. Shimabuku, A. M., Nishimoto, T., Ueda, K., Komano, T. (1992) P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain. J. Biol. Chem. 267, 4308-4311.
5. Holash, J. A., Stewart, P. A. (1993) The relationship of astrocyte-like cells to the vessels that contribute to the blood-ocular barriers. Brain Res. 629, 218-224.
6. Schlingemann, R. O., Hofman, P., Klooster, J., Blaauwgeers, H. G., Van der Gaag, R., Vrensen, G. F. (1998) Ciliary muscle capillaries have blood-tissue barrier characteristics. Exp. Eye Res. 66, 747-754.
7. Wu, J., Zhang, J. J., Koppel, H., Jacob, T. J. (1996) P-glycoprotein regulates a volume-activated chloride current in bovine non-pigmented ciliary epithelial cells. J. Physiol. Lond. 15, 743-755.
8. Tsuji, A., Sakata, A., Tamai, I. (1997) Tissue distribution of the multidrug-resistance gene product P-glycoprotein and its physiological function. Nippon Rinsho. 55, 1059-1063.
9. Thiebaut. F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., Willingham, M. C. (1987) Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl Acad. Sci. USA. 84, 7735-7738.
10. Saha, P., Yang, J. J., Lee, V. H. L. (1998) Existence of a p-glycoprotein drug efflux pump in cultured rabbit conjunctival epithelial cells. Invest. Ophthalmol. Vis. Sci. 39, 1221-1226.
11. Ueda, K., Okamura, N., Hirai, M., Tanigawara, Y., Saeki, T., Kioka, N., Komano, T., Hori, R. (1992) Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 267, 24248-24252.
12. Phung-Ba, V., Warnery, A., Scherman, D., Wils, P. (1995) Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur. J. Pharmacol. 288, 187-192.
13. Hunter, J., Jepson, M. A., Tsuruo, T., Simmons, N. L., Hirst, B. H. (1993) Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J. Biol. Chem. 268, 14991-14997.
14. Fardel, O., Lecureur, V., Daval, S., Corlu, A., Guillouzo, A. (1997) Up-regulation of P-glycoprotein expression in rat liver cells by acute doxorubicin treatment. Eur. J. Biochem. 246, 186-192.
15. Wang, Q., Yang, H., Miller, D. W., Elmquist, W. F. (1995) Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats. Biochem. Biophys. Res. Commun. 211, 719-726.
16. Takano, M., Hasegawa, R., Fukuda, T., Yumoto, R., Nagai, J., Murakami, T. (1998) Interaction with P-glycoprotein and transport of erythomycin, midazolam and ketoconazole in Caco-2 cells. Eur. J. Pharmacol. 358, 289-294.
17. Wigler, P. W., Lyon, K. L., Patterson, F. K., La Loggia, A. J., Diaz Arauzo, H., Reddy, M. S., Cook, J. M. (1994) Epoxide metabolite of quinine and inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Mol. Pharmacol. 46, 562-567.
18. Yee, S. (1997) In vitro permeability across Caco-2 cells (colonie) can predict in vivo (small intestine) absorption in man: fact or myth? Pharm. Res. 14, 763-766.
19. Takano, M., Hirozane, K., Okamura, M., Takayama, A., Nagai, J., Hori, R. (1994) p-Aminohippurate transport in apical and basolateral membranes of the OK kidney epithelial cells. J. Pharmacol. Exp. Ther. 269, 970-975.
20. Lowry, O. H., Rosegrough. N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
21. Shoji, N., Oshika, T., Masuda, K. (1997) Endothelin-1 and intraocular inflammation in pigmented rabbit eyes. Jpn J. Ophthalmol. 41, 150-153.
22. Eytan, G. D., Regev, R., Oren, G., Hurwitz, C. D., Assaraf, Y. G. (1997) Efficiency of P-glycoprotein mediated exclusion of rhodamine dyes from multidrug-resistant cells is determined by their passive transmembrane movement rate. Eur. J. Biochem. 248, 104-112.
23. Levin, V. A. (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23, 682-684.
24. Freddo, T. F., Sacks-Wilner, R. (1989) Interendothelial junctions of the rabbit iris vasculature in anterior uveitis. Invest. Ophthalmol. Vis. Sci. 30, 1104-1111.
25. Freddo, T. F. (1987) Intercellular junctions of the ciliary epithelium in anterior uveitis. Invest Ophthalmol Vis. Sci. 28, 320-329.
26. Moriarty, A. P., Spalton, D. J., Moriarty, B. J., Shilling, J. S., Ffytche, T. J., Bulsara, M. (1994) Studies of the blood-aqueous barrier in diabetes mellitus. Am. J. Ophthalmol. 117, 768-771.