Theoretical and practical considerations for the measurement of P-glycoprotein function in acute myeloid leukemia

Leukemia

Volumn 11, Issue 7, 1997, Pages 1110-1118

  Broxterman, H J ^a,b   Lankelma, J ^a   Pinedo, H M ^a   Eekman, C A ^a   Wahrer D C R ^a   Ossenkoppele, G J ^a   Schuurhuis, G J ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Leukemia; Multidrug resistance; P glycoprotein; PSC833; Rhodamine 123

Indexed keywords

ANTIBODY; CARBOCYANINE; DAUNORUBICIN; FORMALDEHYDE; GLYCOPROTEIN P; RHODAMINE 123; VALSPODAR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; DNA BINDING; DRUG TRANSPORT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; LASER MICROSCOPY; LEUKEMIA CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RADIOASSAY;

EID: 0030848067     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400685     Document Type: Article

References (14)

1. Feller N, Kuiper CM, Lankelma J, Ruhdal JK, Scheper RJ, Pinedo HM, Broxterman HJ. Functional detection of MDR1/P170 and MRP/P190 mediated multidrug resistance in tumour cells by flow cytometry. Br J Cancer 1995; 72: 543-549.
2. Broxterman HJ, Kuiper CM, Schuurhuis GJ, Tsuruo T, Pinedo HM, Lankelma J. Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein. Biochem Pharmacol 1988; 37: 2389-2393.
3. Broxterman HJ, Feller N, Kuiper CM, Boven E, Versantvoort CHM, Teerlink T, Pinedo HM, Lankelma J. Correlation between functional and molecular analysis of mdr1 P-glycoprotein in human solid tumor xenografts. Int J Cancer 1995; 61: 880-886.
4. Schuurhuis GJ, Broxterman HJ, Cervantes A, van Heijningen THM, de Lange JHM, Baak JPA, Pinedo HM, Lankelma J. Quantitative determination of factors contributing to doxorubicin resistance in multidrug resistant cells. J Natl Cancer Inst 1989; 81: 1887-1892.
5. Schuurhuis GJ, Broxterman HJ, De Lange JHM, Pinedo HM, van Heijningen THM, Kuiper CM, Scheffer GL, Scheper RJ, van Kalken CK, Baak JPA, Lankelma J. Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein. Br J Cancer 1991; 64: 857-861.
6. Schuurhuis GJ, Van Heijningen THM, Cervantes A, Pinedo HM, de Lange JHM. Keizer HG, Broxterman HJ, Baak JPA, Lankelma J. Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells. Br J Cancer 1993; 68: 898-908.
7. Spoelstra EC, Dekker H, Schuurhuis GJ, Broxterman HJ, Lankelma J. P-glycoprotein drug efflux pump involved in the mechanisms of intrinsic drug resistance in various colon cancer cell lines. Evidence for saturation of active daunorubicin transport. Biochem Pharmacol 1991; 41: 349-359.
8. Spoelstra EC, Westerhoff HV, Dekker H, Lankelma J. Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur J Biochem 1992; 207: 567-579.
9. Schuurhuis CJ, Broxterman HJ, Ossenkoppele CJ, Baak JPA, Eekman CA, Kuiper CM, Feller N, van Heijningen THM, Klumper E, Pieters R, Lankelma J, Pinedo HM. Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-β-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia. Clin Cancer Res 1995; 1: 81-93.
10. Broxterman HJ, Sonneveld P, Feller N, Ossenkoppele GJ, Währer DCR, Eekman CA, Schoester M, Lankelma J, Pinedo HM, Löwenberg B, Schuurhuis GJ. Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity. Blood 1996; 87: 4809-4816.
11. Broxterman HJ, Lankelma J, Pinedo HM. How to probe clinical tumour samples for P-glycoprotein and multidrug resistance protein. Eur J Cancer 1996; 32A: 1024-1033.
12. Haber DA. Multidrug resistance (MDR1) in leukemia: Is it time to test? Blood 1992; 79: 295-298.
13. Rao W, Anthony DC, Piwnica-Worms D. MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res 1994; 54: 1536-1541.
14. Rao VV, Anthony DC, Piwnica-Worms D. Multidrug resistance P-glycoprotein monoclonal antibody JSB-1 cross-reacts with pyruvate carboxylase. J Histochem Cytochem 1995; 43: 1187-1192.