Pituitary adenylate cyclase-activating peptide, carbachol, and glucose stimulate insulin release in the absence of an increase in intracellular Ca2+

Molecular Pharmacology

Volumn 50, Issue 4, 1996, Pages 1047-1054

  Komatsu, Mitsuhisa ^a   Schermerhorn, Thomas ^a   Straub, Susanne G ^a   Sharp, Geoffrey W G ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CARBACHOL; DIAZOXIDE; EGTAZIC ACID; FORSKOLIN; GLUCOSE; NITRENDIPINE; PHORBOL 13 ACETATE 12 MYRISTATE; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; EXOCYTOSIS; HYPOPHYSIS; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CARBACHOL; CELLS, CULTURED; FORSKOLIN; GLUCOSE; INSULIN; INTRACELLULAR FLUID; ISLETS OF LANGERHANS; NEUROPEPTIDES; NITRENDIPINE; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; STIMULATION, CHEMICAL; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN;

EID: 0029921968     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Wollheim, C. B., and G. W. G. Sharp. Regulation of insulin release by calcium. Physiol. Rev. 61:914-973 (1981).
2. + channels in pancreatic beto-cells: spare-channel hypothesis. Diabetes 37: 495-498 (1988).
3. + channels may control glucose-induced electrical activity in pancreatic B-cells. Biochem. Biophys. Res. Commun. 156:769-775 (1988).
4. Ashcroft, F. M., and P. Rorsman. Electrophysiology of the pancreatic beta-cell. Prog. Biophys. Mol. Biol. 54:87-143 (1989).
5. MacDonald, M. J. Elusive proximal signals of beta-cells for insulin secretion. Diabetes 39:1461-1466 (1990).
6. Komatsu, M., N. Yokokawa, T. Takeda, Y. Nagasawa, T. Aizawa, and T. Yamada. Pharmacological characterization of the voltage-dependent calcium channel of pancreatic B-cell. Endocrinology 125:2008-2014 (1989).
7. Creutz, C. E. The annexins and exocytosis. Science (Washington D. C.) 258:924-931 (1992).
8. 2+-regulated secretion in permeable neuroendocrine cells. Cell 70:765-775 (1992).
9. 2+-dependent insulin release from the pancreatic beta cell. J. Biol. Chem. 269:6149-6152 (1994).
10. Komatsu, M., A. M. McDermott, and G. W. G. Sharp. Sodium fluoride stimulates exocytosis at a late site of calcium interaction in stimulus-secretion coupling: studies with the RINm5F β-cell line. Mol. Pharmacol. 47:496-508 (1995).
11. 2+ influx in rat pancreatic B-cell. Diabetes 41:438-443 (1992).
12. + channels in mouse B cells. J. Clin. Invest. 89:1288-1295 (1992).
13. + channel-independent, insulinotropic action of glucose in the B-cell. Endoer. Regul. 26:159-162 (1992).
14. + channels in mouse B cells. J. Clin. Invest. 91:871-880 (1993).
15. + channel-independent glucose action in rat pancreatic β-cell. Am. J. Physiol. 266:C622-C627 (1994).
16. Detimary, P., P. Gilon, M. Nenquin, and J. Henquin. Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells. Biochem. J. 297:455-461 (1994).
17. Ishihara, F., T. Aizawa, N. Taguchi, Y. Sato, and K. Hashizume. Differential metabolic requirement for initiation and augmentation of insulin release by glucose: a study with rat pancreatic islet. J. Endocrinol. 143: 497-503 (1994).
18. + channel-independent glucose action. Endocrinology 136:3942-3948 (1995).
19. 2+ in rat pancreatic islets. Proc. Natl. Acad. Sci. USA 92:10728-10732 (1995).
20. Straub, S. G., and G. W. G. Sharp. A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating peptide. J. Biol. Chem. 271:1660-1668 (1996).
21. Tang, S., G. Yaney, and G. Sharp. Unusual carbachol responses in RINm5F cells: evidence for a "distal" site of action in stimulus-secretion coupling. Mol. Pharmacol. 47:863-870 (1995).
22. 2+-independent late site in stimulus secretion coupling: studies with the RINm5F β-cell line. J. Biol. Chem. 268:23297-23306 (1993).
23. 2+ concentration. J. Biol. Chem. 264:2455-2462 (1989).
24. Sharp, G. W. G., Y. Le-Marchand-Brustel, T. Yada, L. L. Russo, C. R. Bliss, M. Cormont, L. Monge, and E. Van-Obberghen. Galanin can inhibit insulin release by a mechanism other than membrane hyperpolarization or inhibition of adenylate cyclase. J. Biol. Chem. 264:7302-7309 (1989).
25. 2+-ATPase. Proc. Natl. Acad. Sci. USA 87:2466-2470 (1990).
26. Yada, T., M. Sakurada, K. Ihida, M. Nakata, F. Murata, A. Arimura, and M. Kikuchi. Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells. J. Biol. Chem. 269:1290-1293 (1994).