A regulatory defect of constitutive no-synthase in islet endothelial cells correlates with probability of disease manifestation in BBdp rats

Diabetologia

Volumn 42, Issue 4, 1999, Pages 457-464

  Suschek, C V ^a   Bonmann, E ^b   Kolb Bachofen, V ^a,c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b Neurologische Klin Ruprecht K   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

BBdp rat; Endothelial nitric oxide synthase; Islet endothelial cells; Nitric oxide

Indexed keywords

CITRULLINE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIUM; CELL MIGRATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SPECIFICITY; INSULIN DEPENDENT DIABETES MELLITUS; LEUKOCYTE ADHERENCE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE ADHESION;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; ENDOTHELIUM, VASCULAR; ISLETS OF LANGERHANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0033015493     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051179     Document Type: Article

References (48)

1. Mandrup-Poulsen T, Helquist S, Wogensen LD et al. (1990) Cytokines and free radicals as effector molecules in the destruction of pancreatic beta cells. Curr Top Microbiol Immunol 164: 169-193
2. Cooke A (1990) An overview on possible mechanisms of destruction of the insulin-producing beta cell. Curr Top Microbiol Immunol 164: 125-142
3. Hanenberg H, Kolb-Bachofen V, Kantwerk-Funke G, Kolb H (1989) Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB-rats. Diabetologia 32: 126-134
4. Mandrup-Poulsen T, Bendtzen K, Nerup J, Egeberg J, Nielsen JH (1986) Mechanisms of pancreatic islet-destruction: dose-dependent cytotoxic effect of soluble mononuclear cell mediators on isolated islets of Langerhans. Allergy (Cph) 41: 250-259
5. Prober JS, Cotran RS (1990) The role of endothelial cells in inflammation. Transplantation 50: 537-544
6. Osborn L (1990) Leukocyte adhesion to endothelium in inflammation. Cell 62: 3-6
7. Dolgov VV, Zaikina OE, Bondarenko MF, Repen VS (1982) Aortic endothelium of alloxan diabetic rabbits: a quantitative study using scanning electron microscopy. Diabetologia 22: 338-343
8. Pugliese G, Tilton RG, Williamson JR (1991) Glucose-induced metabolic imbalances in the pathogenesis of diabetic vascular disease. Diabetes Metab Rev 7: 35-59
9. Tucker BJ (1990) Early onset of increased transcapillary albumis escape in awake diabetic rats. Diabetes 39: 919-923
10. Arbogast BW, Berry DL, Newell CL (1984) Injury of arterial endothelial cells in diabetic, sucrose-fed and aged rats. Atherosclerosis 51: 31-45
11. Majno G, Joris I, Handler ES, Desemone J, Mordes JP, Rossini AA (1987) A pancreatic venular defect in the BB/ Wor rat. Am J Pathol 128: 210-215
12. Hänninen A, Salmi M, Simell O, Jalkanen S (1993) Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Diabetes 42: 1656-1662
13. Jones RL, Peterson CM (1981) The fluid phase of coagulation and the accelerated atherosclerosis of diabetes mellitus. Diabetes 30 [Suppl 2]: 33-38
14. Mustard JF, Packham MA (1984) Platelets and diabetes mellitus. N Engl J Med 319: 665-667
15. Rees D, Palmer R, Moncada S (1989) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86: 3375-3381
16. Radomski MW, Palmer RMJ, Moncada S (1987) Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 92: 181-187
17. Radomski MW, Pamer RMJ, Moncada S (1987) Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet ii: 1057-1058
18. Baldwin WM (1982) The symbiosis of immunocompetent and endothelial cells. Immunol Today 3: 267-272
19. Cotran RS, Pober JS (1989) Effects of cytokines on vascular endothelium: their role in vascular and immune injury. Kidney Int 35: 969-975
20. Zimmerman GA, Prescott SM, McIntyre TM (1992) Endothelial cell interactions with granulocytes: tethering and signal molecules. Immunol Today 13: 93-98
21. Suschek C, Rothe H, Fehsel K, Enczmann J, Kolb-Bachofen V (1993) Induction of a macrophage-like nitric oxide synthase in cultured rat aortic endothelial cells. J Immunol 151: 3283-3291
22. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142
23. Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogeneous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88: 4651-4655
24. Suschek C, Fehsel K, Kröncke K-D, Sommer A, Kolb-Bachofen V (1994) Primary cultures of rat capillary endothelial cells: constitutive and cytokine-inducible macrophage-like nitric oxide synthases are expressed and activities regulated by glucose concentration. Am J Pathol 145: 685-695
25. Appels B, Burkart V, Kantwerk-Funke G, Funda J, Kolb-Bachofen V, Kolb H (1988) Spontaneous cytotoxicyty of macrophages against pancreatic islets and insulinoma cells. J Immunol 142: 3803-3808
26. Finter NB (1969) Dye uptake methods of assessing viral cytopathogenicity and their application to Interferon assays. J Gen Virol 5: 419-425
27. Robinson AP, White TM, Mason DW (1986) MRC-O × 43: a monoclonal antibody which reacts with all vascular endothelium in the rat except that of brain capillaries. J Immunol 57: 231-237
28. Barclay AN (1981) Differential reticular elements in rat lymphoid tissue identified by localisation of 1a, Thy-1, and MRC-Ox 2 antigens. Immunology 44: 727-736
29. Wood KS, Buga GM, Byrns RE, Ignarro LJ (1990) Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochem Biophys Res Commun 170: 80-87
30. Boyde TCR, Rahmatullah M (1980) Optimization of conditions for the colorimetric determination of citrulline, using diacetyl monoxime. Anal Biochem 107: 424-431
31. Nunokawa Y, Ishida N, Tanaka S (1993) Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells. Biochem Biophys Res Commun 191: 89-94
32. Marsden PA, Schapert KT, Chen HS et al. (1992) Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett 307: 287-293
33. Sirsjö A, Söderkvist P, Sundquist T, Calsson M, Öst M, Gidlöf A (1994) Different induction mechanisms of mRNA for inducible nitric oxide synthase in rat smooth muscle cells in culture and in aorta strips. FEBS Lett 338: 191-196
34. McGuire PG, Orkin RW (1987) Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrates. Lab Invest 57: 94-104
35. Karasek MA (1989) Microvascular endothelial cell culture. J Invest Dermatol 93: 33S-38S
36. Hewett PW, Murray JC (1993) Human lung microvessel endothelial cells: isolation, culture, and characterisation. Microvasc Res 46: 89-102
37. Montesano R, Orci L, Vassalli P (1985) Human endothelial cell cultures: phenotypic modulation by leucocyte interleukins. J Cell Physiol 122: 424-434
38. Stuehr DJ, Marletta MA (1987) Synthesis of nitrite and nitrate in murine macrophage cell lines. Cancer Res 47: 5590-5594
39. Marletta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS (1988) Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry 27: 8706-8711
40. Kolb-Bachofen V, Kolb H (1989) A role for macrophages in the pathogenesis of type 1 diabetes. Autoimmunity 3: 145-155
41. Schwab E, Burkart V, Freytag G, Kiesel U, Kolb H (1986) Inhibition of immune-mediated low-dose streptozotocin diabetes by agents which reduce vascular permeability. Immunopharmacology 12: 17-21
42. Shimizu Y, Newman W, Tanaka Y, Shaw S (1992) Lymphocyte interaction with endothelial cells. Immunol Today 13: 106-112
43. Duijvestijn AM, Hamann A (1989) Mechanisms and regulation of lymphocyte migration. Immunol Today 10: 23-29
44. Springer T (1990) Adhesion receptors of the immune system. Nature 346: 425-434
45. Butcher EC (1991) Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67: 1033-1036
46. Spinas GA, Laffranchi R, Francoys I, David I, Richter C, Reinecke M (1998) The early phase of glucose-stimulated insulin secretion requires nitric oxide. Diabetologia 41: 292-299
47. Kim JA, Berliner JA, Natarajan RD, Nadler JL (1994) Evidence that glucose increases monocyte binding to human aortic endothelial cells. Diabetes 43: 1103-1107
48. Wu G, Meininger CJ (1995) Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat. Am J Physiol 269 (Heart Circ Physiol 38): H1312-H1318