Clotrimazole analogues: Effective blockers of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurones

British Journal of Pharmacology

Volumn 132, Issue 4, 2001, Pages 889-898

  Shah, M M ^a   Miscony, Z ^a   Javadzadeh Tabatabaie, M ^a   Ganellin, C R ^a   Haylett, D G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Clotrimazole; Hippocampal pyramidal neurones; SK potassium channels; Slow afterhyperpolarization; UCL 1848; UCL 1880; UCL 2027

Indexed keywords

1,1' (PENTANE 1,5 DIYL) N,N (PENTANE 1,5 DIYL)BIS(4 ANUNOQUINOLINIUM)DIFLUOROACETATE; 2 CHLOROPHENYL BISPHENYL METHANOL; 2 TRIPHENYLMETHYLAMINOTHIAZOLE; 3 [N [1 (2 CHLOROPHENYL) 1,1 DIPHENYL]METHYL]AMINOPYRIDINE; APAMIN; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CLOTRIMAZOLE; UCL 1848; UCL 1880; UCL 2027; UNCLASSIFIED DRUG;

AFTERHYPERPOLARIZATION; ANIMAL CELL; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG SELECTIVITY; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

EID: 0035127468     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703895     Document Type: Article

References (45)

1. +channels by cytochrome-P-450 inhibitors
2. Distribution of slow AHP channels on hippocampal CA1 pyramidal neurons
3. + channels with nanomolar affinity
4. Small-conductance calcium-activated potassium channels
5. + transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives
6. Dendritic calcium channels and hippocampal long-term depression
7. Calcium current activated by potassium ions in voltage-clamped rat hippocampal pyramidal neurones
8. Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus
9. + channels from human erythrocytes
10. 2+ channel alpha(1C) subunit
11. + channel inactivation, spike broadening, and after-hyperpolarization in Kv beta 1.1-deficient mice with impaired learning
12. Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells
13. Gating properties of single SK channels in hippocampal CA1 pyramidal neurons
14. Determinants of apamin and d-tubocurarine block in SK potassium channels
15. A human intermediate conductance calcium-activated potassium channel
16. + channels
17. + channel
18. hSK4, a member of a novel subfamily of calcium-activated potassium channels
19. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads
20. + current (I-Ks) and its augmentation by carbachol in rat pancreatic acini
21. Small-conductance, calcium-activated potassium channels from mammalian brain
22. + current sI(AHP) in hippocampal pyramidal neurons
23. Calcium-dependent current generating the afterhyperpolarization of hippocampal-neurons
24. Properties of two calcium-activated hyperpolarisations in rat hippocampal-neurons
25. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes
26. 2+ channels in hippocampal neurons
27. Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age-dependent and concentration-dependent manner
28. + current sI(AHP) by a phosphatase-kinase balance under basal conditions in rat CA1 pyramidal neurons
29. Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole
30. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells
31. + currents in neurones: Types, physiological roles and modulation
32. Channels underlying the slow afterhyperpolarization in hippocampal pyramidal neurons: Neurotransmitters modulate the open probability
33. + channels expressed in mammalian cell lines
34. 2+ channels involved in the generation of the slow afterhyperpolarization in cultured rat hippocampal pyramidal neurons
35. + current in hippocampal pyramidal neurons
36. Action-potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells
37. Potassium currents in hippocampal pyramidal cells
38. + channels stably expressed in HEK 293 cells
39. The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guineapig ventricular myocytes
40. Analysis of current fluctuations during after-hyperpolarization current in dentate granule neurones of the rat hippocampus
41. Calcium-activated potassium channels
42. The M1 muscarinic agonist CI-I017 facilitates trace eyeblink conditioning in aging rabbits and increases the excitability of CA1 pyramidal neurons
43. + current by clotrimazole in rat anterior pituitary GH(3) cells
44. Mechanism of calcium gating in small-conductance calcium-activated potassium channels
45. + channel in rat hippocampal neurons