Voltage-dependent, slowly activating K+ current (I(Ks)) and its augmentation by carbachol in rat pancreatic acini

Pflugers Archiv European Journal of Physiology

Volumn 438, Issue 5, 1999, Pages 604-611

  Kim, Sung Joon ^a   Greger, Rainer ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Carbachol; Exocrine secretion; Pancreatic acinus; Potassium current (I(ks))

Indexed keywords

BARIUM ION; CARBACHOL; CHLORIDE ION; CLOTRIMAZOLE; POTASSIUM ION; TETRYLAMMONIUM;

ACINAR CELL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CHLORIDE CONDUCTANCE; CHLORIDE CURRENT; CHLORIDE TRANSPORT; CHOLINERGIC ACTIVITY; DEPOLARIZATION; MEMBRANE STEADY POTENTIAL; NONHUMAN; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0032833008     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004249900071     Document Type: Article

References (35)

1. 1. Aughsteen AA, Kataoka K, Shair SA (1996) Correlative morphometric and biochemical study on pancreatic amylase in normal and streptozotocin-diabetic rats. Pancreas 13:295-303
2. Ks cardiac potassium current. Nature 384:78-80
3. + channel blocker 293B. Pflügers Arch 434: 499-501
4. minK channel complex. Trends Physiol Sci 18:26-29
5. 5. Busch AE, Kavanaugh MP, Varnum MD, Adelman JP, North RA (1992) Regulation by second messengers of the slowly activating, voltage-dependent potassium current expressed in Xenopus oocytes. J Physiol (Lond) 450:491-502
6. Ks channels by the chromanol 293B. Pflügers Arch 432:1094-1096
7. 2+. J Biol Chem 274: 282-287
8. 8. Cook DI, Young JA (1996) Function of exocrine pancreas. In: Greger R, Windhorst U (eds) Comprehensive human physiology. Springer, Berlin Heidelberg New York
9. + channels. Am J Physiol 273:C531-C540
10. 10. Greger R (1996) The membrane transporters regulating epithelial NaCl secretion. Pflügers Arch 432:579-588
11. + channels in the basolateral membrane of rat tracheal epithelia. J Membr Biol 154:251-257
12. 12. Kaczmarek LK, Blumenthal EM (1997) Properties and regulation of the minK potassium channel protein. Physiol Rev 77:627-642
13. 2+ gradients triggering unidirectional fluid secretion from exocrine pancreas. Nature 348:735-739
14. + current in rat pituitary nerve terminals. J Physiol (Lond) 497:711-725
15. + channel of very small conductance in the basolateral membane of rat pancreatic acini. Pflügers Arch DOI 10.1007/s004249900070
16. + conductance. Pflügers Arch 429:519-530
17. + secretion in vestibular dark cells. Am J Physiol 267:C857-C864
18. + channels under hormonal control in pig pancreas acinar cells. Nature 305:228-232
19. 19. Noble D, Tsien RW (1969) Outward membrane currents activated in the plateau range of voltage in cardiac Purkinje fibres. J Physiol (Lond) 200:205-231
20. 20. Petersen OH (1992) Stimulus-secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J Physiol (Lond) 448:1-51
21. 21. Randriamampita C, Chanson M, Trautmann A (1988) Calcium and secretogogues-induced conductances in rat exocrine pancreas. Pflügers Arch 411:53-57
22. + current: differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96:195-215
23. Ks potassium channel. Nature 384:80-83
24. 24. Schmid A, Schulz I (1995) Characterization of single potassium channels in mouse pancreatic acinar cells. J Physiol (Lond) 484:661-676
25. 25. Schmid A, Feick P, Schulz I (1997) Inwardly rectifying, voltage-dependent and resting potassium currents in rat pancreatic acinar cells in primary culture. J Physiol (Lond) 504:259-270
26. 26. Slawik M, Zdevik A, Hug MJ, Kerstan D, Leipziger J, Greger R (1996) Whole-cell conductive properties of rat pancreatic acini. Pflügers Arch 432:112-120
27. + currents in guinea pig pancreatic acinar cells. Am J Physiol 255:G275-G285
28. 28. Takumi T, Ohkubo H, Nakanishi S (1988) Cloning of membrane protein that induces a slow voltage-gated potassium current. Science 242: 1042-1045
29. 29. Thorn P, Petersen OH (1994) A voltage-sensitive transient potassium current in mouse pancreatic acinar cells. Pflügers Arch 428:288-295
30. 2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate. Cell 74:661-668
31. + current in guinea pig heart cells. Am J Physiol 253:H1321-H1324
32. 32. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Towbin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT (1996) Positional cloning of a novel potassium channel gene:KVLQT1 mutations cause cardiac arrhythmias. Nature Genet 12:17-23
33. + conductance of rat colonic crypt base cells. Pflügers Arch 432:81-88
34. - but not the Nernst voltage for nonselective cation channels in rat pancreatic acinar cells. Cell Physiol Biochem 6:123-128
35. 35. Zdebik A, Hug MJ, Greger R (1997) Chloride channels in the luminal membrane of rat pancreatic acini. Pflügers Arch 434: 188-194