The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell

British Journal of Pharmacology

Volumn 129, Issue 4, 2000, Pages 627-630

  Shah, M ^a   Haylett, D G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Afterhyperpolarization; Apamin; COS 7 cells; Dequalinium; HEK293 cells; SK1; Tubocurarine; UCL1848

Indexed keywords

1,1 [1,5 PENTANDIYL] N,N [1,5 PENTANDIYL] BIS [4 AMINOQUINOLINIUM DITRIFLUOROACETATE; APAMIN; CALCIUM ION; DEQUALINIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION; TRIFLUOROACETIC ACID; TUBOCURARINE CHLORIDE; UCL 1848; UNCLASSIFIED DRUG; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN1 PROTEIN, HUMAN; KCNN1 PROTEIN, RAT; NICOTINIC RECEPTOR BLOCKING AGENT; POTASSIUM CHANNEL BLOCKING AGENT; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; MAMMAL CELL; MONKEY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; XENOPUS; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; KIDNEY; PHYSIOLOGY; RAT;

ANIMALS; APAMIN; CALCIUM; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DEQUALINIUM; HUMANS; KIDNEY; NICOTINIC ANTAGONISTS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; TRANSFECTION; TUBOCURARINE; XENOPUS;

EID: 0033621773     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703111     Document Type: Article

References (15)

1. + channels with nanomolar affinity. Br. J. Pharmacol., 128, 39P.
2. + channels in hepatocytes and of nicotinic responses in skeletal muscle. Eur. J. Pharmacol., 236, 201-207.
3. Dunn, P.M. (1994). Dequalinium, a selective blocker of the slow afterhyperpolarization in rat sympathetic neurons in culture. Eur. J. Pharmacol., 252, 189-194.
4. + channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530. Br. J. Pharmacol., 117, 35-42.
5. Hosseini, R., Benton, D.C.H., Haylett, D.G. & Moss, G.W.J. (1999). Cloning of an SK channel from rat sympathetic neurones. J. Physiol., 518, 122P.
6. Ishii, T.M., Maylie, J. & Adelman, J.P. (1997). Determinants of apamin and d-tubocurarine block in SK potassium channels. J. Biol. Chem., 272, 23195-23200.
7. Jurman, M.E., Boland, L.M., Liu, Y. & Yellen, G. (1994). Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques, 17, 876-881.
8. Khawaled, R., Bruening-Wright, A., Adelman, J.P. & Maylie, J. (1999). Bicuculline block of small-conductance calcium-activated potassium channels. Pflugers Arch.-Eur. J. Physiol., 438, 314-321.
9. Kohler, M., Hirschberg, B., Bond, C.T., Kinzie, J.M., Marrion, N.V., Maylie, J. & Adelman, J.P. (1996). Small-conductance, calcium-activated potassium channels from mammalian brain. Science, 273, 1709-1714.
10. Lewis, T.M., Harkness, P.C., Sivilotti, L.G., Colquhoun, D. & Millar, N.S. (1997). The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type. J. Physiol., 505, 299-306.
11. + currents in neurones: Types, physiological roles and modulation. Trends in Neurosci., 19, 150-154.
12. Vergara, C., Latorre, R., Marrion, N.V. & Adelman, J.P. (1998). Calcium-activated potassium channels. Curr. Opin. Neurobiol., 8, 321-329.
13. + channels. J. Biol. Chem., 269, 18053-18061.
14. 2+ - activated potassium channels. Arch. Biochem. Biophys., 346, 151-160.
15. Yu, S.P. & Kerchner, G.A. (1998). Endogenous voltage-gated potassium channels in human embryonic kidney (HEK293) cells. J. Neurosci. Res., 52, 612-617.