DNA metabolism in Mycobacterium tuberculosis: Implications for drug resistance and strain variability

Scandinavian Journal of Infectious Diseases

Volumn 33, Issue 2, 2001, Pages 101-105

  Boshoff, H I M ^a   Durbach, S I ^a   Mizrahi, V ^a  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DNA POLYMERASE; ETHAMBUTOL; ISONIAZID; NITRATE REDUCTASE; NITRIC OXIDE; PYRAZINAMIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REACTIVE OXYGEN METABOLITE; RECA PROTEIN; SUPEROXIDE DISMUTASE; TUBERCULOSTATIC AGENT;

ANAEROBIC METABOLISM; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIAL VIRULENCE; BASE MISPAIRING; CONTROLLED STUDY; DNA DAMAGE; DNA METABOLISM; DNA POLYMORPHISM; DNA REPAIR; DNA REPLICATION; DNA SEQUENCE; GENE LOCUS; GENE MUTATION; GENETIC CODE; GENETIC VARIABILITY; HUMAN; MATHEMATICAL MODEL; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NITROSATION; NONHUMAN; OXIDATIVE STRESS;

DNA DAMAGE; DNA, BACTERIAL; DRUG RESISTANCE, MICROBIAL; EVOLUTION, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS;

EID: 0035109705     PISSN: 00365548     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655401750065463     Document Type: Article

References (54)

1. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update
2. Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination
3. Negligible genetic diversity of Mycobacterium tuberculosis host immune system protein targets. Evidence of limited selective pressure
4. Some observations on the genetics of isoniazid resistance in the tubercle bacilli
5. Evidence for the adaptive evolution of mutation rates
6. DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence?
7. Method for staining both acid-fast and chromophobic tubercle bacilli with carbolfuschin
8. Studies on the effects of starvation on mycobacteria
9. Nitrate reduction as a marker for hypoxic shiftdown of Mycobacterium tuberculosis
10. Anaerobic nitrate reductase (narGHJI) activity of Mycobacterium bovis BCG in vitro and its contribution to virulence in immunodeficient mice
11. Nitrate respiration is essential for growth but not persistence of M. bovis
12. Ferrous iron dependent nitric oxide production in nitrate reducing cultures of Escherichia coli
13. Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates
14. Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: Induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors
15. A novel antioxidant gene from Mycobacterium tuberculosis
16. Regulation of hmp gene transcription in Mycobacterium tuberculosis: Effects of oxygen limitation and nitrosative and oxidative stress
17. NoxR3, a novel gene from Mycobacterium tuberculosis protects Salmonella typhimurium from nitrosative and oxidative stress
18. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
19. Protein synthesis is shut down in dormant Mycobacterium tuberculosis and is reversed by oxygen or heat shock
20. Inducible acid tolerance mechanisms in enteric bacteria
21. Generation of an endogenous DNA-methylating agent by nitrosation in Escherichia coli
22. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria
23. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid
24. Loss of oxyR in Mycobacterium tuberculosis
25. Interdependence of mycobacterial iron regulation, oxidative stress response and isonaizid resistance
26. Identification and functional characterization of thioredoxin of Mycobacterium tuberculosis
27. Two-dimensional electrophoresis for analysis of Mycobacterium tuberculosis culture filtrate and purification and characterization of six novel proteins
28. Export of recombinant Mycobacterium tuberculosis superoxide dismutase is dependent upon both information in the protein and mycobacterial export machinery. A model for studying export of leaderless proteins by pathogenic mycobacteria
29. Dormancy of Mycobacterium tuberculosis and latency of disease
30. Drug sensitivity and environmental adaptation of mycobacterial cell wall components
31. Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro
32. The Mycobacterium tuberculosis katG promoter region contains a novel upstream activator
33. The role of DNA damage in stationary phase ("adaptive") mutation
34. The importance of repairing stalled replication forks
35. Enzymes of evolutionary change
36. Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
37. General recombination
38. Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS)
39. Stress resistance in Staphylococcus aureus
40. Novel DNA polymerases offer clues to the molecular basis of mutagenesis
41. Bridging the gap: A family of novel DNA polymerases that replicate faulty DNA
42. Escherichia coli DNA polymerase IV mutator activity: Genetic requirements and mutational specificity
43. Genetic antagonism and hypermutability in Mycobacterium smegmatis
44. The within-host population dynamics of antibacterial chemotherapy: Conditions for the evolution of resistance
45. Population dynamics of tuberculosis treatment: Mathematical models of the roles of non-compliance and bacterial heterogeneity in the evolution of drug resistance
46. How drug resistance emerges as a result of poor compliance during short-course chemotherapy for tuberculosis
47. Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs
48. Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family
49. Activation of pyrazinamide and nicotinamide in acidic environments in vitro
50. PncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: Spread of a monoresistant strain in Quebec, Canada
51. Genomics, biology and evolution of the Mycobacterium tuberculosis complex
52. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
53. Immunological studies of PE-PGRS proteins of Mycobacterium tuberculosis
54. Variable human minisatellite-like regions in the Mycobacterium tuberculosis genome