Protein synthesis is shutdown in dormant Mycobacterium tuberculosis and is reversed by oxygen or heat shock

FEMS Microbiology Letters

Volumn 158, Issue 1, 1998, Pages 139-145

  Hu, Yan Min ^a   Butcher, Philip D ^a   Sole, Kath ^a   Mitchison, D A ^a   Coates, A R M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Anaerobiosis; Dormancy; Heat shock; Mycobacterium tuberculosis; Protein synthesis

Indexed keywords

OXYGEN; PROTEIN;

ANAEROBIC METABOLISM; ARTICLE; BACTERIAL GROWTH; HEAT SHOCK; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANAEROBIOSIS; BACTERIAL PROTEINS; CELL CYCLE; HEAT-SHOCK RESPONSE; MYCOBACTERIUM TUBERCULOSIS; OXYGEN;

BACILLI; BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; POSIBACTERIA;

EID: 0031912339     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00514-4     Document Type: Article

References (19)

1. Kochi, A. (1991) The global tuberculosis situation and the new control strategy of the World Heath Organization. Tubercle 72, 1-6.
2. Dickinson, J.M. and Mitchison, D.A. (1981) Experimental models to explain the high sterilizing activity of rifampin in the chemotherapy of tuberculosis. Am. Rev. Respir. Dis. 123, 367-371.
3. Rich, A.R. and Follis, Jr., R.H. (1942) The effect of low oxygen tension upon the development of experimental tuberculosis. Bull. Johns Hopkins Hosp. 71, 345.
4. Canetti, G.J. (1955) The tubercle bacillus in the pulmonary lesion of man. In: Histobacteriology and its Bearing on Therapy of Pulmonary Tuberculosis, pp. 118-126. Springer, New York.
5. Wayne, L.G. (1976) Dynamics of submerged growth of Mycobacterium tuberculosis under aerobic and microaerophilic conditions. Am. Rev. Respir. Dis. 114, 807-811.
6. Wayne, L.G. (1994) Dormancy of Mycobacterium tuberculosis and latency of disease. Eur. J. Clin. Microbiol. Infect. Dis. 13, 908-914.
7. Wayne, L.G. and Lin, K.Y. (1982) Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions. Infect. Immun. 37, 1042-1049.
8. Wayne, L.G. and Sramek, H.A. (1994) Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 38, 2054-2058.
9. Wayne, L.G. and Hayes, L.G. (1996) An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 64, 2062-2069.
10. Yuan, Y., Crane, D.D. and Barry III, C.E. (1996) Stationary phase-associated protein expression in Mycobacterium tuberculosis: function of the mycobacterial-crystallin homolog. J. Bacteriol. 178, 4484-4492.
11. Patel, B.K., Banerjee, D.K. and Butcher, P.D. (1991) Characterization of the heat shock response in Mycobacterium bovis BCG. J. Bacteriol. 173, 7982-7987.
12. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
13. Young, D.B. and Garbe, T.R. (1991) Heat shock proteins and antigens of Mycobacterium tuberculosis. Infect. Immun. 59, 3086-3093.
14. Goldberg, A.L. and St. John, A.C. (1976) Intracellular protein degradation in mammalian and bacterial cells: part 2. Annu. Rev. Biochem. 45, 747-803.
15. Reeve, C.A., Bockman, A.T. and Matin, A. (1984) Role of protein degradation in the survival of carbon-starved Escherichia coli and Salmonella typhimurium. J. Bacteriol. 157, 758-763.
16. Jenkins, D.E., Chaisson, S.A. and Matin, A. (1990) Starvation-induced cross protection against osmotic challenge in Escherichia coli. J. Bacteriol. 172, 2779-2781.
17. Jenkins, D.E., Auger, E.A. and Matin, A. (1991) Role of RpoH, a heat shock regulator protein, in Escherichia coli carbon starvation protein synthesis and survival. J. Bacteriol. 173, 1992-1996.
18. Lange, R. and Hengge-Aronis, R. (1991) Identification of a central regulator of stationary phase gene expression in Escherichia coli. Mol. Microbiol. 5, 49-59.
19. Wallace, J.G. (1961) The heat resistance of tubercle bacilli in the lungs of infected mice. Am. Rev. Respir. Dis. 83, 866-871.