Multidrug resistance in enteric and other Gram-negative bacteria

FEMS Microbiology Letters

Volumn 139, Issue 1, 1996, Pages 1-10

  George, Anthony M ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

Antibiotic; Efflux; Gram negative bacteria; Multidrug resistance

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; AZLOCILLIN; CARBENICILLIN; CARUMONAM; CEFEPIME; CEFOPERAZONE; CEFOTAXIME; CEFPIROME; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; ENOXACIN; ERYTHROMYCIN; IMIPENEM; LATAMOXEF; MENADIONE; MINOCYCLINE; MITOMYCIN C; NALIDIXIC ACID; NORFLOXACIN; NOVOBIOCIN; PARAQUAT; PEFLOXACIN; PIPERACILLIN; TETRACYCLINE; UNINDEXED DRUG;

ANTIBIOTIC RESISTANCE; DRUG TRANSPORT; GRAM NEGATIVE BACTERIUM; MOLECULAR GENETICS; MULTIDRUG RESISTANCE; NONHUMAN; OPERON; PRIORITY JOURNAL; REGULON; REVIEW;

BACTERIA (MICROORGANISMS); ENTERIC BACTERIA; NEGIBACTERIA;

EID: 0029971845     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1097(96)00127-9     Document Type: Short Survey

References (42)

1. Davies, J. (1994) Inactivation of antibiotics and the dissemination of resistance genes. Science 264, 375-381.
2. Stokes, H.W. and Hall, R.M. (1989) A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: Integrons. Mol. Microbiol. 3, 1669-1683.
3. Lewis, K. (1994) Multidrug resistance pumps in bacteria: variations on a theme. Trends Biochem. Sci. 19, 119-123.
4. Poole, K. (1994) Bacterial multidrug resistance - emphasis on efflux mechanisms and Pseudomonas aeruginosa. J. Antimicrob. Chemother. 34, 453-456.
5. Maness, M.J. and Sparling, P.F. (1973) Multiple antibiotic resistance due to a single mutation in Neisseria gonorrhoeae. J. Infect. Dis. 128, 321-330.
6. Williams Smith, H. (1976) Mutants of Klebsiella pneumoniae resistant to several antibiotics. Nature 259, 307-308.
7. Levy, S.B. (1992) Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36, 695-703.
8. Nikaido, H. (1994) Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264, 382-388.
9. Ma, D., Cook, D.N., Hearst, J.E. and Nikaido, H. (1994) Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol. 2, 489-493.
10. Neyfakh, A.A., Borsch, C.M. and Kaatz, G.W. (1993) Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrob. Agents Chemother. 3, 128-129.
11. Ahmed, M., Lyass, L., Markham, P.N., Taylor, S.S., Vazquez-Laslop, N. and Neyfakh, A.A. (1995) Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J. Bacteriol. 177, 3904-3910.
12. Paulson, I.T., Littlejohn, T. G., Radstrom, P., Sundstrom, L., Skold. O., Swedberg, G. and Skurray, R.A. (1993) The 3′ conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants. Antimicrob. Agents Chemother. 37, 761-768.
13. Lomovskaya, O. and Lewis, K. (1992) emr, an Escherichia coli locus for multidrug resistance. Proc. Natl. Acad. Sci. USA 89, 8938-8942.
14. Cohen, S.P., Hachler, H. and Levy, S.B. (1993) Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. J. Bacteriol. 175, 1484-1492.
15. George, A.M. and Levy, S.B. (1983a) Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid determined efflux of tetracycline. J. Bacteriol. 155, 531-540.
16. George, A.M. and Levy, S.B. (1983b) Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics. J. Bacteriol. 155, 541-548.
17. Ma, D., Cook, D.N., Alberti, M., Pon, N.G., Nikaido, H. and Hearst, J.E. (1993) Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175, 6299-6313.
18. Poole, K., Krebes, K., McNally, C. and Neshat, S. (1993) Multiple antibiotic resistance in Pseudomonas aeruginosa; evidence for involvement of an efflux operon. J. Bacteriol. 175, 7363-7372.
19. Ariza, R.R., Li, Z., Ringstad, N. and Demple, B. (1995) Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein. J. Bacteriol. 177, 1655-1661.
20. Ishida, H., Fuziwara, H., Kaibori, Y., Horiuchi, T., Sato, K. and Osada, Y. (1995) Cloning of multidrug resistance gene pqrA from Proteus rulgaris. Antimicrob. Agents Chemother. 39, 453-457.
21. Hagman, K.E., Pan, W., Spratt, B.G., Balthazar, J.T., Judd, R.C. and Shafer, W.M. (1995) Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 141, 611-622.
22. Charvalos, E., Tselentis, Y., Hamzehpour, M.M., Kohler, T. and Pechere, J.-C. (1995) Evidence for an efflux pump in multidrug-resistant Campylobacter jejuni. Antimicrob. Agents Chemother. 39, 2019-2022.
23. George, A.M., Hall, R.M. and Stokes, H.W. (1995) Multidrug resistance in Klebsiella pneumoniae: a novel gene, ramA. confers a multidrug resistance phenotype in Escherichia coli. Microbiology 141, 1909-1920.
24. Ma D., Cook, D.N., Alberti, M., Pon, N.G., Nikaido, H. and Hearst, J.E. (1995) Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microb. 16, 45-55.
25. Okusu, H., Ma, D. and Nikaido, H. (1996) AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178, 306-308.
26. Skarstad, K., Thony, B., Hwang, D.S. and Kornberg, A. (1993) A novel binding protein of the origin of the Escherichia coli chromosome. J. Biol. Chem. 268, 5365-5370.
27. Nakajima, H., Kobayashi, K., Kobayashi, M., Asako, H. and Aono, R. (1995) Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli. Appl. Environ. Microbiol. 61, 2302-2307.
28. Li, Z. and Demple, B. (1994) SoxS, an activator of superoxide stress genes in Escherichia coli. J. Biol. Chem. 269, 18371-18377.
29. Greenberg, J.T., Monach, P., Chou, J.H., Josephy, P.D. and Demple, B. (1990) Positive control of a global antioxidant defence regulon activated by superoxide-generating agents in Escherichia coli. Proc. Natl. Acad. Sci. USA 87, 6181-6185.
30. Gallegos, M.-T., Michan, C. and Ramos, J.L. (1993) The XylS/AraC family of regulators. Nucleic Acids Res. 21, 807-810.
31. Miller, P.F., Gambino, L.F., Sulavik, M.C. and Gracheck, S.J. (1994) Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli. Antimicrob. Agents Chemother. 38, 1773-1779.
32. McMurry, L.M., George, A.M. and Levy, S.B. (1994) Active efflux of chloramphenicol in susceptible Escherichia coli strains and in multiple-antibiotic-resistant (Mar) mutants. Antimicrob. Agents Chemother. 38, 542-546.
33. Cohen, S.P., Hooper, D.C., Wolfson, J.S., Souza, K.S., McMurry, L.M. and Levy, S.B. (1988) Endogenous active efflux of norfloxacin in susceptible Escherichia coli. Antimicrob. Agents Chemother. 32, 1187-1191.
34. Seoane, A.A. and Levy, S.B. (1995) Characterisation of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli. J. Bacteriol. 177, 3414-3419.
35. Hachler, H., Cohen, S.P. and Levy, S.B. (1991) marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli. J. Bacteriol. 173, 5532-5538.
36. Martin, R.G. and Rosner, J.L. (1995) Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences. Proc. Natl. Acad. Sci. USA 92, 5456-5460.
37. Gambino, L., Gracheck, S.J. and Miller, P.F. (1993) Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli. J. Bacteriol. 175, 2888-2894.
38. Lomovskaya, O., Lewis, K. and Matin, A. (1995) EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. J. Bacteriol. 177, 2328-2334.
39. - and is soluble in organic solvents. J. Biol. Chem. 270, 6856-6863.
40. Komatsu, T., Ohta, M., Kido, N., Arakawa, Y., Ito, H., Mizuno, T. and Kato, N. (1990) Molecular characterisation of an Enterobacter cloacae gene (romA) which pleiotropically inhibits the expression of Escherichia coli outer membrane proteins. J. Bacteriol. 172, 4082-4089.
41. Hamzehpour, M.M., Pechere, J.-C., Plesiat, P. and Kohler, T. (1995) OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39, 2392-2396.
42. Li, X.-Z., Nikaido, H. and Poole, K. (1995) Role of MexA-MexB-OprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39, 1948-1953.