Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus

Journal of Bacteriology

Volumn 179, Issue 11, 1997, Pages 3786-3789

  Ginn, Samantha L ^a   Brown, Melissa H ^a   Skurray, Ronald A ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ANTIPORTER; BACTERIAL PROTEIN; BETA GALACTOSIDE; HYBRID PROTEIN; METAL; PROTON; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MEMBRANE; CYTOPLASM; GENE ISOLATION; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; REPORTER GENE; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 0030998934     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.11.3786-3789.1997     Document Type: Article

References (27)

1. Allard, J. D., and K. P. Bertrand. 1992. Membrane topology of the pBR322 tetracycline resistance protein. TelA-PhoA gene fusions and implications for the mechanism of TetA membrane insertion. J. Biol. Chem. 267:17809-17819.
2. Brickman, E., and J. Beckwith. 1975. Analysis of the regulation of Escherichia coli alkaline phosphatase synthesis using deletions and φ80 transducing phages. J. Mol. Biol. 96:307-316.
3. Claros, M. G., and G. von Heijne. 1994. TopPred II: an improved software for membrane protein structure predictions. CABIOS 10:685-686.
4. Eckert, B., and C. F. Beck. 1989. Topology of the transposon Tn10-encoded tetracycline resistance protein within the inner membrane of Escherichia coli. J. Biol. Chem. 264:11663-11670.
5. Engelman, D. M., T. A. Steitz, and A. Goldman. 1986. Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu. Rev. Biophys. Biophys. Chem. 15:321-353.
6. + antiporter of Staphylococcus aureus. FEBS Lett. 391:243-246.
7. Griffith, J. K., M. E. Baker, D. A. Rouch, M. G. P. Page, R. A. Skurray, I. T. Paulsen, K. F. Chater, S. A. Baldwin, and P. J. F. Henderson. 1992. Membrane transport proteins: implications of sequence comparisons. Curr. Opin. Cell Biol. 4:684-695.
8. Guay, G. G., S. A. Khan, and D. M. Rothstein. 1993. The tet(K) gene of plasmid pT181 of Staphylococcus aureus encodes an efflux protein that contains 14 transmembrane helices. Plasmid 30:163-166.
9. Gutierres, C., and J. C. Devedjian. 1989. A plasmid facilitating in vitro construction ot phoA gene fusions in Escherichia coli. Nucleic Acids Res. 17:3999.
10. R controls. Gene 37: 131-138.
11. Iordanescu, S. 1976. Three distinct plasmids originating in the same Staphylococcus aureus strain. Arch. Roum. Pathol. Exp. Microbiol. 35:111-118.
12. Kunkel, T. A., J. D. Roberts, and R. A. Zakour. 1987. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 154:367-382.
13. Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:105-132.
14. Levy, S. B. 1992. Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36:695-703.
15. Manoil, C., and J. Beckwith. 1985. TnphoA: a transposon probe for protein export signals. Proc. Natl. Acad. Sci. USA 82:8129-8133.
16. Marger, M. D., and M. H. Saier, Jr. 1993. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem. Sci. 18:13-20.
17. Michaelis, S., H. Inouye, D. Oliver, and J. Beckwith. 1983. Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli. J. Bacteriol. 154:366-374.
18. Paulsen, I. T., M. H. Brown, S. J. Dunstan, and R. A. Skurray. 1995. Molecular characterization of the staphylococcal multidrug resistance export protein QacC. J. Bacteriol. 177:2827-2833.
19. Paulsen, I. T., M. H. Brown, T. G. Littlejohn, B. A. Mitchell, and R. A. Skurray. 1996. Molecular characterization of the multidrug resistance proteins QacA and QacB: membrane topology and identification of residues involved in specificity for divalent cations. Proc. Natl. Acad. Sci. USA 93: 3630-3635.
20. Paulsen, I. T., M. H. Brown, and R. A. Skurray. 1996. Proton-dependent multidrug efflux systems. Microbiol. Rev. 60:575-608.
21. Paulsen, I. T., and R. A. Skurray. 1993. Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes - an analysis. Gene 124:1-11.
22. Rouch, D. A., D. S. Cram, D. DiBerardino, T. G. Littlejohn, and R. A. Skurray. 1990. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline-and sugar-transport proteins. Mol. Microbiol. 4:2051-2062.
23. Smith, R. L., J. L. Banks, M. D. Snavely, and M. E. Maguire. 1993. Sequence and topology of the CorA magnesium transport systems of Salmonella typhimurium and Escherichia coli. Identification of a new class of transport protein. J. Biol. Chem. 268:14071-14080.
24. Traxler, B., D. Boyd, and J. Beckwith. 1993. The topological analysis of integral cytoplasmic membrane proteins. J. Membr. Biol. 132:1-11.
25. Vieira, J., and J. Messing. 1987. Production of single-stranded plasmid DNA. Methods Enzymol. 153:3-11.
26. von Heijne, G. 1981. Membrane proteins: the amino acid composition of membrane-penetrating segments. Eur. J. Biochem. 120:275-278.
27. + antiporter. FEBS Lett. 365:193-197.