Phlebotomus papatasi Saliva Inhibits Protein Phosphatase Activity and Nitric Oxide Production by Murine Macrophages

Infection and Immunity

Volumn 66, Issue 4, 1998, Pages 1534-1537

  Waitumbi, John ^a   Warburg, Alon ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOPROTEIN PHOSPHATASE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; GENETICS; MACROPHAGE; METABOLISM; PHLEBOTOMUS; PHYSIOLOGY; SALIVA;

ANIMALS; ENZYME INHIBITORS; MACROPHAGES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHLEBOTOMUS; PHOSPHOPROTEIN PHOSPHATASE; SALIVA;

EID: 0032037783     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.4.1534-1537.1998     Document Type: Article

References (32)

1. Ashford, R. W., P. Desjeux, and P. deRaadt. 1992. Estimation of populations at risk of infection and number of cases of leishmaniasis. Parasitol. Today 8: 104-105.
2. Bialojan, C., and A. Takai. 1988. Inhibitory effect of a marine-sponge toxin, okadaic acid on protein phosphatases. Biochem. J. 256:283-290.
3. Bradley, D. J. 1987. Visceral and post kala azar dermal leishmaniasis, p. 551-582. In W. Peters and R. Killick-Kendrick (ed.), The leishmaniases in biology and medicine, vol. II. Academic Press, San Diego, Calif.
4. Cohen, P. 1989. The structure and regulation of protein phosphatases. Annu. Rev. Biochem. 58:435-508.
5. Cohen, P., C. F. B. Holmes, and Y. Tsukitani. 1990. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci. 15:98-102.
6. Doherty, M., and R. Coffman. 1996. Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice. Exp. Parasitol. 84: 124-135.
7. Dong, Z., X. Yang, K. Xie, S. H. Juang, N. Liansa, and I. J. Fidler. 1995. Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatase 1 and 2A. J. Leukocyte Biol. 58:725-732.
8. Green, S. J., C. A. Nacy, and M. S. Meltzer. 1991. Cytokine-induced synthesis of nitrogen oxide in macrophages: a protective host response to Leishmania and other intracellular pathogens. J. Leukocyte Biol. 50:93-103.
9. Hall, L. R., and T. G. Titus. 1995. Sand fly vector saliva selectively modulates macrophage functions that inhibit killing of Leishmania major and nitric oxide production. J. Immunol. 155:3501-3506.
10. Haystead, T. J., A. T. R. Sim, D. Carling, R. C. Honnor, Y. Tsukitani, P. Cohen, and D. G. Hardie. 1989. Effects of the tumor promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337:78-81.
11. Ingebritsen, S. T., and P. Cohen. 1983. Protein phosphatases: properties and role in cellular regulation. Science 221:331-333.
12. Jaffrey, S., and S. Snyder. 1995. Nitric oside: a neural messenger. Annu. Rev. Cell Dev. Biol. 11:417-440.
13. Lerner, E. A., J. M. C. Ribeiro, R. J. Nelson, and M. Lerner. 1991. Isolation of Maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J. Biol. Chem. 266:11234-11236.
14. Liew, F. Y., and C. A. O'Donnel. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32:161-259.
15. Lima, H., and R. Titus. 1996. Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice. Infect. Immun. 64:5442-5445.
16. Menon, J. N., and P. A. Bretscher. 1996. Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge. Eur. J. Immunol. 26:243-249.
17. Modi, G. B., and R. B. Tesh. 1983. A simple technique for mass rearing Lutzomyia longipalpis and Phlebotomus papatasi. J. Med. Entomol. 20:568-569.
18. Qureshi, A., A. Asahina, M. Ohnuma, M. Tajima, R. Granstein, and E. Lerner. 1996. Immunomodulatory properties of maxadilan, the vasodilator peptide from sand fly salivary gland extracts. Am. J. Trop. Med. Hyg. 54: 665-671.
19. Reiner, S. L., S. Zheng, D. B. Corry, and R. M. Locksley. 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165:37-46.
20. Ribeiro, J. M. C., A. Vachereau, G. B. Modi, and R. B. Tesh. 1989. A novel vasodilatory peptide from the salivary glands of the sandfly Lutzomyia longipalpis. Science 243:212-214.
21. Sacks, D. L., and P. V. Perkins. 1985. Development of infective stage Leishmania promastigotes within phlebotomine sand flies. Am. J. Trop. Med. Hyg. 34:456-459.
22. Samuelson, J., E. Lerner, R. Tesh, and R. Titus. 1991. A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J. Exp. Med. 173:49-54.
23. Shelonikar, S., and T. S. Ingebritsen. 1984. Protein (serine and threonine) phosphatases. Methods Enzymol. 107:102-107.
24. Streger, S., N. Donhauser, H. Thung, M. Rollinghoff, and C. Bogdan. 1996. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J. Exp. Med. 183:1501-1514.
25. Theodos, C. M., J. M. C. Ribeiro, and R. G. Titus. 1991. Analysis of enhancing effect of sandfly saliva on Leishmania infection in mice. Infect. Immun. 59:1592-1598.
26. Theodos, C. M., and R. G. Titus. 1993. Salivary gland material from the sand fly Lutzomyia longipalpis has an inhibitory effect on macrophage function in vitro. Parasite Immunol. 15:481-487.
27. Titus, R., and J. M. C. Ribeiro. 1988. Salivary gland lysates of the sandfly Lutzomyia longipalpis enhance Leishmania infectivity. Science 239:1306-1308.
28. Vidal, S. M., D. Malo, K. Vogan, E. Skamene, and P. Gros. 1993. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73:469-485.
29. Walton, B. C. 1987. American cutaneous and mucocutaneous leishmaniasis, p. 638-653. In W. Peters and R. Killick-Kendrick (ed.), The leishmaniases in biology and medicine, vol. II. Academic Press, San Diego, Calif.
30. Warburg, A. Unpublished data.
31. Warburg, A., E. Saraiva, G. C. Lanzaro, R. Titus, and F. Neva. 1994. Saliva of Lutzomyia longipalpis sibling species differs in its composition and propensity to enhance leishmaniasis. Philos. Trans. R. Soc. Lond. B 354:223-230.
32. Warburg, A., and Y. Schlein. 1986. The effect of post-bloodmeal nutrition of Phlebotomus papatasi on the transmission of Leishmania major. Am. J. Trop. Med. Hyg. 35:926-930.