Differential effects of 15-deoxy-Δ12,14-prostaglandin j2 and a peroxisome proliferator-activated receptor γ agonist on macrophage activation

Journal of Leukocyte Biology

Volumn 69, Issue 4, 2001, Pages 631-638

  Guyton, Kelly ^a   Bond, Robert ^b   Reilly, Chris ^a   Gilkeson, Gary ^a   Halushka, Perry ^a   Cook, James ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

BRL 49653; ERK 1 2; I B ; NO; TNF ; TxB2

Indexed keywords

15 DEOXY DELTA 12,14 PROSTAGLANDIN J2; BACTERIUM LIPOPOLYSACCHARIDE; CICAPROST; CYCLOPENTENONE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROSTAGLANDIN D2; PROSTAGLANDIN J2; ROSIGLITAZONE; THROMBOXANE B2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; MACROPHAGE ACTIVATION; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0035075676     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.69.4.631     Document Type: Article

References (45)

1. Response of man to endotoxin
2. Nitric oxide: Physiology, pathophysiology, and pharmacology
3. Role of cyclo-oxygenase products in septic shock
4. Multiple organ failure syndrome in the 1990's
5. The pathogenesis of sepsis
6. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
7. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
8. Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages
9. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide
10. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells
11. Prostacyclin analogs suppress the synthesis of tumor necrosis factor-alpha in LPS-stimulated human peripheral blood mononuclear cells
12. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes
13. Prostaglandin D2 inhibits inducible nitric oxide synthase expression in rat vascular smooth muscle cells
14. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
15. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
16. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro
17. The nuclear receptor superfamily: The second decade
18. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
19. Novel sequence determinants in peroxisome proliferator signaling
20. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
21. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
22. Discovery of ligands for the nuclear peroxisome proliferator-activated receptors
23. Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase
24. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
25. 15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway
26. Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-delta 12,14-prostaglandin J2
27. Platelet inhibitory, and haemodynamic effects of a new stable PGI2 analogue, cicaprost (ZK 96480), in different animal species and in man
28. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids
29. Differential alteration of lipoxygenase and cyclooxygenase metabolism by rat peritoneal macrophages induced by endotoxin tolerance
30. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
31. Endotoxin activation of mitogen-activated protein kinase in THP-1 cells; diminished activation following endotoxin desensitization
32. Inhibition of nuclear factor kappa B by prostaglandin A1: An effect associated with heat shock transcription factor activation
33. The I kappa B/NF-kappa B system: A key determinant of mucosal inflammation and protection
34. Endotoxin-induced cross-tolerance to Gram-positive sepsis
35. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors
36. Anti-inflammatory actions of 15-deoxy-delta (12,14)-prostaglandin J(2) and troglitazone: Evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression
37. HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats
38. Heat shock protein 70 suppresses astroglial-inducible nitricoxide synthase expression by decreasing NFkappaB activation
39. The Influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia
40. Effect of heat stress on LPS-induced fever and tumor necrosis factor
41. Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo
42. Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators
43. Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists
44. Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress
45. Inducible cyclooxygenase may have anti-inflammatory properties