Upregulation of toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NK-κB activation

Infection and Immunity

Volumn 69, Issue 5, 2001, Pages 2788-2796

  Liu, Y ^a   Wang, Y ^a   Yamakuchi, M ^a   Isowaki, S ^a   Nagata, E ^a   Kanmura, Y ^a   Kitajima, I ^a   Maruyama, I ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; DACTINOMYCIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID A; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEPTIDOGLYCAN; POLYMYXIN B; PYRROLIDINE DITHIOCARBAMATE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; HL-60 CELLS; HUMANS; LIPID A; LIPOPOLYSACCHARIDES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; NF-KAPPA B; PEPTIDOGLYCAN; RECEPTORS, CELL SURFACE; SHOCK, SEPTIC; SWINE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0035055217     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.5.2788-2796.2001     Document Type: Article

References (53)

1. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
2. Function and activation of NF-κB in the immune system
3. Control of apoptosis by Rel/NF-κB transcription factors
4. A conserved signalling pathway: The Drosophila toll-dorsal pathway
5. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
6. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors
7. Toll-like receptor-4 mediates lipopolysaccharide induced signal transduction
8. The cell wall components peptidoglycan and lipoteichoic acid from staphylococcus aureus act in synergy to cause shock and multiple organ failture
9. Bacterial lipopolysaccharide activates NF-kappaB through Toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells
10. Human Toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide
11. Genetic approaches in mice to understand Rel/NF-κB and IκB function: Transgenics and knockouts
12. Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages
13. CD14 is a cell-activating receptor for bacterial peptidoglycan
14. Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1
15. Molecules and mechanisms operating in septic shock: Lessons from knockout mice
16. NOD mice are defective in proteasome production and activation of NF-κB
17. Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis
18. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
19. Cutting edge: Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin
20. Cutting edge: Inflammatory signaling by borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2
21. Phylogenetic perspectives in innate immunity
22. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product
23. Lipopolysaccharides (LPS) of oral black-pigmented bacteria induce tumor necrosis factor production by LPS-refractory C3H/HeJ macrophages in a way different from that of Salmonella LPS
24. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
25. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB
26. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
27. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
28. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
29. Lipopolysaccharide inhibits TNF-induced apoptosis: Role of nuclear factor-κB activation and reactive oxygen intermediates
30. Upregulation of mouse CD14 expression in Kupffer cells by lipopolysaccharide
31. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression
32. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
33. Endotoxin and disease mechanism
34. Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
35. The human Toll signaling pathway: Divergence of nuclear factor-κB and JNF SAPK activation upstream of tumor necrosis factor-associated factor 6 (TRAF6)
36. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr 4 gene
37. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
38. Endotoxin-tolerant mice have mutation in Toll-like receptor 4 (tlr4)
39. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
40. A family of human receptors structurally related to Drosophila Toll
41. Biogenesis of eukaryotic 20S proteasomes: The complex maturation pathway of a complex enzyme
42. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor-2
43. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
44. TLR6: A novel member of an expanding Toll-like receptor family
45. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
46. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
47. n gene: In vivo evidence for a dominant negative mutation
48. BCG-induced enhancement of endotoxin sensitivity in C3H/HeJ mice. I. In vivo studies
49. Strategies for the treatment of sepsis
50. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling
51. Signaling events induced by lipopolysaccharide-activated Toll-like receptor 2
52. Cutting edge: Recognition of gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
53. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signalling mediators in cultured human dermal endothelial cells and mononuclear phagocytes