Acute pancreatitis: New emerging concepts;Pancréatite aiguë: Nouvelles données physiopathologiques

Gastroenterologie Clinique et Biologique

Volumn 25, Issue 2, 2001, Pages 164-176

  Frossard, J L ^a   Hadengue, A ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Cathepsin B. Oxidative stress; Experimental acute pancreatitis; Fibrosis; Regeneration; Trypsinogen

Indexed keywords

CATHEPSIN B; CHEMOKINE; CYTOKINE; PANCREAS ENZYME; TRYPSIN; TRYPSINOGEN;

ACUTE PANCREATITIS; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME RELEASE; HUMAN; MICROCIRCULATION; OXIDATIVE STRESS; PANCREAS NECROSIS; REGENERATION; REVIEW;

ACUTE DISEASE; ALCOHOLISM; APOPTOSIS; CATHEPSIN B; CHEMOKINES; CHOLELITHIASIS; CYTOKINES; HUMANS; NECROSIS; OXIDATIVE STRESS; PANCREATITIS; REGENERATION; RISK FACTORS; TRYPSIN; TRYPSINOGEN;

EID: 0035044889     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (142)

1. A clinically based classification system for acute pancreatitis
2. Acute pancreatitis
3. Etiology and pathophysiology of acute pancreatitis
4. Fatal acute pancreatitis
5. Pathobiology of experimental acute pancreatitis
6. Causes of acute and recurrent pancreatitis. Clinical considerations and clues to diagnosis
7. Gallstone migration as a cause for acute pancreatitis
8. Etiology of pancreatitis
9. Prognostic signs and nonoperative peritoneal lavage in acute pancreatitis
10. Prognostic factors in acute pancreatitis
11. APACHE II: A severity of disease classification system
12. Prediction of outcome in acute pancreatitis: A comparative study of APACHE II, clinical assessment and multiple factor scoring systems
13. C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis
14. Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis
15. Interleukin-8 and neutrophil activation in acute pancreatitis
16. Trypsinogen activation peptides assay in the early prediction of acute pancreatitis
17. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: A multicentre study
18. Influence of etiology on the course and outcome of acute pancreatitis
19. Etiology and age have only a limited influence on the course of acute pancreatitis
20. Pathophysiology of pancreatitis, role of cytokines and other mediators of inflammation
21. New Approaches to acute pancreatitis : Role of inflammatory mediators
22. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis
23. Etiopathogenesis of acute pancreatitis
24. Homology in amino-terminal sequence of precursors to pancreatic secretory proteins
25. Pancreatic secretory enzymes
26. Update: Big duct, little duct, or toxi metabolic pathogenesis of pancreatitis
27. Effect of long term alcohol feeding on the pancreas in the rat
28. Pancreatic basal secretion in alcohol fed and normal dogs
29. Fine structure of protein precipitation in acinar lumina in the normal human pancreas and pancreatitis
30. Alcohol and the pancreas
31. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis
32. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis
33. Pancreatic acinar cell function and morphology in rats chronically fed and ethanol diet
34. Experimental pancreatitis in the rat. Sodium taurocholate-induced acute hemorrhagic pancreatitis
35. Effects of in vivo cholinergic stimulation of rat exocrine pancreas
36. Hormone-induced pancreatitis
37. Acute interstitial pancreatitis in the rat induced by excessive doses of pancreatic secretagogue
38. Endogenous cathepsin activates trypsinogen in extracts of dog pancreas
39. Possible lysosomal activation of pancreatic zymogens: Activation of both human trypsinogens by cathepsin B and spontaneous acid activation of human trypsinogen 1
40. Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats
41. Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis
42. Contribution à l'étude des cellules glandulaires (pancréas)
43. Cerulein-induced pancreatitis in rats: Increased lysosomal enzyme activity and autophagocytosis
44. Evidence of intracellular activation of serine proteases in acute cerulein-induced pancreatitis in rats
45. Does antecedent ethanol intake affect course of taurocolate pancreatitis in rats?
46. In vivo rat pancreatic acinar cell function during supramaximal stimulation with caerulein
47. Esterase inhibitors prevent lysosomal enzyme redistribution in two non invasive models of experimental pancreatitis
48. Effects of short-term pancreatic duct obstruction in rats
49. Intracellular aspects of the process of protein secretion
50. Trafficking of lysosomal enzymes in normal and disease states
51. Pancreatic duct obstruction in rabbits causes digestive zymogen and lysosomal enzyme colocalization
52. Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis
53. Failure of the cathepsin B Inhibitor E64 to protect against caerulein and choline-deficient diet induced pancreatitis
54. Inhibition of cysteine proteinases in lysosomes and whole cells
55. Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B
56. Trypsinogen activation in rat pancreatic acinar cells hyperstimulated by caerulein
57. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini
58. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
59. Elevated calcium and activation of trypsinogen in rat pancreatitic acini
60. The role of calcium in pancreatitis
61. Continuous calcium channel blocker infusion in experimentally acute pancreatitis: Effects on pancreas and liver function
62. The hereditary pancreatitis gene maps to long arm of chromosome 7
63. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
64. Human cationic trypsinogen. Role of Asn21 in zymogen activation and implications in hereditary pancreatitis
65. Hereditary pancreatitis and pancreatic carcinoma
66. Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis
67. Lysosomal enzymes in pancreatitis
68. Oxidative stress in acute pancreatitis
69. Oxidative stress: An important phenomenon with pathogenetic significance in the progression of acute pancreatitis
70. Role of oxidative stress in pathogenesis of caerulein-induced acute pancreatitis
71. The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models
72. In vivo assessment of lipid peroxidation in experimental edematous and necrotizing rat pancreatitis
73. Cerium-based histochemical demonstration of oxidative stress in taurocholate-induced acute pancreatitis in rats. A confocal laser scanning microscopy study
74. Oxygen free radicals in acute pancreatitis of the rat
75. Evidence for a role of oxygen derived free radicals in the pathogenesis of caerulein induced acute pancreatitis in rats
76. Biology of disease : Free radicals and tissue injury
77. Reactive oxygen species in living systems : Source, biochemistry and role in human disease
78. Superoxide dismutase and catalase: A possible role in established pancreatitis
79. Effects of antioxidants and free radicals scavengers in three different models of acute pancreatitis
80. Transgenic copper/zinc superoxide dismutase ameliorates caerulein-induced pancreatitis in mice
81. Metallothionein protects against cerulein-induced acute pancreatitis: Analysis using transgenic mice
82. Fatal pancreatitis: A consequence of excessive leukocyte stimulation?
83. Acute pancreatitis after cardiopulmonary bypass
84. Incidence, management and significance of surgical complications after pancreatic transplantation
85. Morphological studies of graft pancreatitis following pancreas transplantation
86. Adverse effects of therapeutic vasoconstrictors in experimental acute pancreatitis
87. Determinants of pancreatic microcirculation in acute pancreatitis in rats
88. Increased nitric oxide activity in a rat model of acute pancreatitis
89. An endothelial nitric oxide synthase Inhibitor aggravates CDL-induced acute pancreatitis in rats
90. On the protective mechanisms of nitric oxide in acute pancreatitis
91. The effects of nitric oxide synthase inhibitors on acute necrotising pancreatitis in rats
92. Leukocyte-endothelial adherence correlates with pancreatic nitric oxide production in early cerulein-induced pancreatitis in rats
93. The role of nitric oxide in caerulein-induced acute pancreatitis and the recovery process after inflammatory damage
94. Interstitial trypsinogen release and its relevance to the transformation of mild into necrotizing pancreatitis in rats
95. Scoring systems for predicting outcome in acute hemorrhagic necrotizing pancreatitis
96. Randomized, doubleblind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis
97. Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini
98. Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo
99. Early NF-kappaB activation is associated with hormone-induced pancreatitis
100. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis
101. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis
102. Platelet-activating factor: A mediator of pancreatic inflammation during cerulein hyperstimulation
103. Targeted disruption of the beta-chemokine receptor CCRI protects against pancreatitis-associated lung injury
104. Role of substance P and the neurokinin-l receptor in acute pancreatitis and pancreatitis-associated lung injury
105. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE)
106. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis
107. Experimental acute pancreatitis induced by platelet activator factor in rabbits
108. Prospective placebo-controlled randomized trial of lexipafant in predicted severe acute pancreatitis
109. Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis
110. The role of biliary obstruction in the pathogenesis of acute pancreatitis in the opossum
111. Early ductal decompression prevents the progression of biliary pancreatitis: An experimental study in the opossum
112. Experimental pancreatitis in the rat. Sodium taurocholate-induced acute hemorrhagic pancreatitis
113. A model to study acute pancreatitis in the dog
114. Pancreatic duct pressure, duct permeability and acute pancreatitis
115. Effect of recombinant platelet-activating factor acetylhydrolase on two models of experimental acute pancreatitis
116. Interleukin-10 prevents necrosis in murine experimental pancreatitis
117. Serum interleukin-10 in human acute pancreatitis
118. Patterns of pancreatic cell death: Apoptosis versus oncosis
119. Apoptosis, oncosis and necrosis. An overview of cell death
120. The pathways of cell death: Oncosis, apoptosis and necrosis
121. Phospholipase A2 in acute pancreatitis: New biochemical pathological aspects
122. A multicenter study of phospholipase A2 in patients in intensive care units
123. Pulmonary vascular injury in pancreatitis: Evidence for a major role played by pancreatic elastase
124. Pancreatic phospholipase A2 in proximal tubules of rat kidney in experimental pancreatitis and after intravenous injection of the enzyme
125. Increased concentrations of synovial-type phospholipase A2 in serum and pulmonary and renal complications in acute pancreatitis
126. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis
127. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat
128. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis
129. The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis
130. Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation
131. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury
132. Experimental production of pancreatitis with ethionine
133. Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet
134. Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice
135. CD4(+) T cells play an important role in acute experimental pancreatitis in mice
136. Progression from acute to chronic pancreatitis. A pathologist's view
137. Fibroblasts stimulate acinar cell proliferation through IGF-l during regeneration from acute pancreatitis
138. TGFbeta and the extracellular matrix in pancreatitis
139. Extracellular matrix is reduced by inhibition of transforming growth factor β1 in pancreatitis in the rat
140. Transforming growth factor β promotes development of fibrosis after repeated courses of acute pancreatitis in mice
141. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells