An inhibitor of sequence-specific proteolysis that targets the substrate rather than the enzyme

Chemistry and Biology

Volumn 8, Issue 4, 2001, Pages 391-397

  Zhang, Zhiwen ^a   Ly, Thi ^a   Kodadek, Thomas ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cleavage site; Protease inhibitor; Sequence specific proteolysis; Substrate targeted inhibitor

Indexed keywords

ENZYME INHIBITOR; HYBRID PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA CONVERTING ENZYME; PEPTIDE; PROTEIN PRECURSOR; PROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN PROCESSING;

AMINO ACID SEQUENCE; BINDING SITES; CASPASE 1; DRUG DESIGN; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-1; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0035033985     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00021-7     Document Type: Article

References (30)

1. Shao Y., Still W.C. Sequence-selective receptors of peptides. A simple molecular design for construction of large combinatorial libraries of receptors. J. Org. Chem. 61:1996;6086-6087.
2. Still W.C. Discovery of sequence-selective peptide binding by synthetic receptors using encoded combinatorial libraries. Acc. Chem. Res. 29:1996;155-163.
3. Cheng Y., Suenaga T., Still W.C. Sequence-selective peptide binding with peptido-A, B-trans-steroidal receptor selected from an encoded combinatorial receptor library. J. Am. Chem. Soc. 118:1996;1813-1814.
4. Burger M.T., Still W.C. Simple strucutral requirements for sequence-selective peptide receptors? Tripeptide binding by a podand ionophore. J. Org. Chem. 62:1997;4785-4790.
5. Chen C.-T., Wagner H., Still W.C. Fluorescent, sequence-selective peptide detection by synthetic small molecules. Science. 279:1998;851-853.
6. Hossain M.A., Schneider H.-J. Sequence-selective evaluation of peptide side-chain interaction. New artificial receptors for selective recognition in water. J. Am. Chem. Soc. 120:1998;11208-11209.
7. Dong D.L., Liu R., Sherlock R., Wigler M.H., Nestler H.P. Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus. Chem. Biol. 6:1999;133-141.
8. Zhang Z., Zhu W., Kodadek T. Selection and practical applications of peptide-binding peptides. Nat. Biotechnol. 18:2000;71-74.
9. Hu J., O'Shea E.K., Kim P.S., Sauer R.T. Sequence requirements for coiled-coils: Analysis with λ repressor-GCN4 leucine zipper fusions. Science. 250:1990;1400-1403.
10. Hu J.C. Repressor fusions as a tool to study protein-protein interactions. Structure. 3:1995;431-433.
11. Zhang Z., Murphy A., Hu J.C., Kodadek T. Genetic selection of short peptides that support protein oligomerization in vivo. Curr. Biol. 9:1999;417-420.
12. Patarca R., Flectcher M.A. Interleukin-1: Basic science and clinical applications. Crit. Rev. Oncog. 8:1997;143-188.
13. Tocci M.J., Thornberry N.A., Bull H.G., Lee T.D., Shiely J.E. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature. 356:1992;768-774.
14. Cerretti D.P., Kozlosky C.J., Mosley B., Nelson N., Van Ness K., Greenstreet T.A., March C.J., Kronheim S.R., Druck T., Cannizzaro L.A., Huebner K., Black R.A. Molecular cloning of the interleukin-1β converting enzyme. Science. 256:1992;97-100.
15. Dinarello C.A. Interleukin-beta, interleukin-18 and the interleukin-1 beta converting enzyme. Ann. N. Y. Acad. Sci. 856:1998;1-11.
16. Fantuzzi G., Dinarello C.A. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J. Clin. Immunol. 19:1999;1-11.
17. Ghayur T., Banerjee S., Hugunin M., Butler D., Herzog L., Carter A., Quintal L., Sekut L., Talanian R., Paskind M., Wong W., Kamen R., Tracey D., Allen H. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature. 386:1997;619-623.
18. Nicholson D.W., Thornberry N.A. Caspases: killer proteases. Trends Biochem. Sci. 22:1997;299-306.
19. Humke E.W., Shriver S.K., Starovasnik M.A., Fairbrother W.J., Dixit V.M. ICEBERG: A novel inhibitor of interleukin-1β generation. Cell. 103:2000;99-111.
20. Heyduk T., Ma Y., Tang H., Ebright R.H. Fluorescence anisotropy: Rapid, quantitative assay for protein-DNA and protein-protein interactions. Methods Enzymol. 274:1996;492-503.
21. Sambrano G.R., Huang W., Faruqi T., Mahrus S., Craik C., Coughlin S. Cathepsin G activates protease-activated receptor-4 in human platelets. J. Biol. Chem. 275:2000;6819-6823.
22. Zhang L., Torgerson T.R., Liu X.-Y., Timmons S., Colosia A.D., Hawiger J., Tam J.P. Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide molecules. Proc. Natl. Acad. Sci. USA. 95:1998;9184-9189.
23. Schwarze S.R., Ho A., Vocero-Akbani A., Dowdy S.F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 285:1999;1569-1572.
24. Gius D.R., Ezhevsky S.A., Becker-Hapak M., Nagahara H., Wei M.C., Dowdy S.F. Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1. Cancer Res. 59:1999;2577-2580.
25. Kip1 induces cell migration. Nat. Biotechnol. 4:1998;1449-1452.
26. Derossi D., Chassaing G., Prochiantz A. Trojan peptides: the penetrin system for intracellular delivery. Trends Cell Biol. 8:1998;84-87.
27. Lim K., Ho J.X., Keeling K., Gilliland G.L., Ruker F., Carter D.C. Three-dimensional structure of Schistosoma japonium GST fused with a six amino acid conserved neutralizing epitope of gp41 from HIV. Protein Sci. 3:1994;2233-2244.
28. Griffiths A.D., Duncan A.R. Strategies for selection of antibodies by phage. Curr. Opin. Biotechnol. 9:1998;102-108.
29. Schneider S., Buchert M., Georgiev O., Catimel B., Halford M., Stacker S.A., Baechi T., Moelling K., Hovens C.M. Mutagenesis and selection of PDZ domains that bind new protein targets. Nat. Biotechnol. 17:1999;170-175.
30. Rozinov M.N., Nolan G.P. Evolution of peptides that modulate the spectral qualities of bound small molecule fluorophores. Chem. Biol. 5:1998;713-728.