Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 4, 1996, Pages 219-222

  Takahashi, Mami ^a   Fukutake, Masato ^a   Yokota, Shigeru ^a   Ishida, Kaori ^a   Wakabayashi, Keiji ^a   Sugimura, Takashi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Aberrant crypt foci; Azoxymethane; Cyclooxygenase 2; Nimesulide; Rat colon carcinogenesis

Indexed keywords

AZOXYMETHANE; NIMESULIDE; PIROXICAM; PROSTAGLANDIN SYNTHASE INHIBITOR; SULINDAC;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; COLON; CONTROLLED STUDY; PREVENTION; PRIORITY JOURNAL; RAT;

ANIMALS; AZOXYMETHANE; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; INTESTINAL MUCOSA; ISOENZYMES; MALE; NEOPLASMS, EXPERIMENTAL; PRECANCEROUS CONDITIONS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED F344; SULFONAMIDES;

EID: 0029939286     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01209649     Document Type: Article

References (30)

1. Bird RP (1987) Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 37: 147-151
2. Böttcher I, Schweizer A, Glatt M, Werner H (1987) A sulphonamido-indanone derivative CPG 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats. Drugs Exp Clin Res 13: 237-245
3. Broder S (1993) Perspectives on cancer in Japan and the United States. Jpn J Cancer Res 84: 821-830
4. Cipollini F, Mecozzi V, Altilia F (1989) Endoscopic assessment of the effects of nimesulide on the gastric mucosa: comparison with indomethacin. Curr Ther Res 45: 1042-1048
5. Copeland RA, Williams JM, Giannaras J, Nurnberg S, Covington M, Pinto D, Pick S, Trzaskos JM (1994) Mechanism of selective inhibition of the inducible isoform of prostaglandin GH synthase. Proc Natl Acad Sci USA 91: 11202-11206
6. DuBois RN, Awad J, Morrow J, Roberts LJ II, Bishop R (1994) Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. Clin Invest 93: 493-498
7. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107: 1183-1188
8. Kargman SL, O'Neill GP, Vickers PJ, Evans JF, Mancini JA, Jothy S (1995) Expression of prostaglandin GH synthase-1 and -2 protein in human colon cancer. Cancer Res 55: 2556-2559
9. Labyle D, Fischer D, Vielh P, Drouhin F, Pariente A, Bories C, Duhamel O, Trousset M, Attali P (1991) Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 101: 635-639
10. Langman MJS (1989) Epidemiologic evidence on the association between peptic ulceration and antiinflammatory drug use. Gastroenterology 96: 640-646
11. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC, Seibert K (1994) Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci USA 91: 3228-3232
12. Meade EA, Smith WL, DeWitt DL (1993) Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem 268: 6610-6614
13. Mereto E, Frencia L, Ghia M (1994) Effect of aspirin on incidence and growth of aberrant crypt foci induced in the rat colon by 1,2-dimethylhydrazine. Cancer Lett 76: 5-9
14. Pereira MA, Barnes LH, Rassman VL, Kelloff GV, Steele, VE (1994) Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents. Carcinogenesis 15: 1049-1054
15. Pretlow TP, Barrow BJ, Ashton WS, O'Riordan MA, Pretlow TG, Jurcisek JA, Stellato TA (1991) Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res 51: 1564-1567
16. Rao CV, Rivenson A, Simi B, Zang E, Kelloff G, Steele V, Reddy BS (1995) Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res 55: 1464-1472
17. Reddy BS, Maruyama H, Kelloff G (1987) Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drugs, during different stages of rat colon tumor development. Cancer Res 47: 5340-5346
18. Reddy BS, Tokumo K, Kulkarni N, Aligia C, Kelloff G (1992) Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds. Carcinogenesis 13: 1019-1023
19. Reddy BS, Rao CV, Rivenson A, Kelloff G (1993) Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 14: 1493-1497
20. Reitz DB, Li JJ, Norton MB, Reinhard EJ, Collins JT, Anderson GD, Gregory SA, Koboldt CM, Perkins WE, Seibert K, Isakson PC (1994) Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors. J Med Chem 37: 3878-3881
21. Rigas B, Goldman IS, Levine L (1993) Altered eicosanoid levels in human colon cancer. J Lab Clin Med 122: 518-523
22. Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR (1991) Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 22: 287-294
23. Swingle KF, Moore GGI (1984) Preclinical pharmacological studies with nimesulide. Drugs Exp Clin Res 10: 587-597
24. Takahashi M, Minamoto T, Yamashita N, Yazawa K, Sugimura T, Esumi H (1993) Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid. Cancer Res 53: 2786-2789
25. Takahashi S, Ogawa K, Ohshima H, Esumi H, Ito N, Sugimura T (1991) Induction of aberrant crypt foci in the large intestine of F344 rats by oral administration of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine. Jpn J Cancer Res 82: 135-137
26. Taniguchi Y, Ikesue A, Yokoyama K, Noda K, Debuchi H, Nakamura T, Toda A, Shimeno H (1995) Selective inhibition by nimesulide, a novel non-steroidal anti-inflammatory drug, with prostaglandin endoperoxide synthase-2 activity in-vitro. Pharm Sci 1: 173-175
27. Thun MJ, Namboodiri MM, Heath CW Jr (1991) Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 325: 1593-1596
28. Tofanetti O, Casciarri I, Cipolla PV, Cazzulani P, Omini C (1989) Effect of nimesulide on cyclo-oxygenase activity in rat gastric mucosa and inflammatory exudate. Med Sci Res 17: 745-746
29. Tudek B, Bird RP, Bruce WR (1989) Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods. Cancer Res 49: 1236-1240
30. Xie W, Chipman JG, Robertson DL, Erikson RL, Simmons DL (1991) Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc Natl Acad Sci USA 88: 2692-2696