Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA

Journal of Pharmacology and Experimental Therapeutics

Volumn 296, Issue 3, 2001, Pages 1006-1012

  Minchin, R F ^a   Carpenter, D ^a   Orr, R J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOSOME; PLASMID DNA; POLYCATION; POLYINOSINIC ACID; POLYLYSINE;

ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DNA DEGRADATION; GENE TARGETING; GENE THERAPY; HALF LIFE TIME; ISOLATED LIVER; LIVER CLEARANCE; LIVER PERFUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; LIPOSOMES; LIVER; MALE; METABOLIC CLEARANCE RATE; PERFUSION; PLASMIDS; POLY I; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 0035123026     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Expression cloning of a novel scavenger receptor from human endothelial cells
2. Human gene therapy
3. In vivo fate of phosphorothioate antisense oligodeoxynucleotides: Predominant uptake by scavenger receptors on endothelial liver cells
4. Targeting of a cholecystokinin-DNA complex to pancreatic cells in vitro and in vivo
5. Effect of altered tissue binding on the disposition of barbital in the isolated perfused rat liver: Application of the axial dispersion model
6. Clearance of human antibody/DNA immune complexes and free DNA from the circulation of the nonhuman primate
7. Uptake and intracellular trafficking of asialoglycoprotein-polylysine-DNA complexes in isolated rat hepatocytes
8. Effect of DNA size and strandedness on the in vivo clearance and organ localization of DNA
9. Kinetics and mechanisms for removal of circulating single-stranded DNA in mice
10. Hepatic binding of DNA is mediated by a receptor on nonparenchymal cells
11. Heparin stimulation of plasminogen activator secretion by macrophage-like cell line RAW264.7; Role of the scavenger receptor
12. Comparison between intratracheal and intravenous administration of liposome-DNA complexes for cystic fibrosis lung gene therapy
13. Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells
14. The fate of plasmid DNA after intravenous injection in mice: Involvement of scavenger receptors in its hepatic uptake
15. Lung macrophage uptake of unopsonized environmental particulates: Role of scavenger-type receptors
16. Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors
17. Multicompartment, numerical model of cellular events in the pharmacokinetics of gene therapies
18. Cancer gene therapy using plasmid DNA: Pharmacokinetic study of DNA following injection in mice
19. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
20. Biodistribution and gene expression of lipid/plasmid complexes after systemic administration
21. Disposition of fluorescein-labelled dextran (150 kD) in isolated perfused livers from control and diabetic rats
22. The pharmacology of gene therapy
23. Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells
24. Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer
25. Pharmacokinetics and tissue distribution of a DNA-methyltransferase antisense (MT-AS) oligonucleotide and its catabolites in tumor-bearing nude mice
26. Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy
27. Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake
28. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
29. Drug delivery systems in gene therapy
30. Regional "pro-drug" gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma
31. Fate of injected deoxyribonucleic acid in mice
32. Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia
33. Receptor-mediated gene delivery in vivo: Partial correction of genetic analbuminemia in Nagase rats
34. The lysine cluster in the collagen-like domain of the scavenger receptor provides for its ligand binding and ligand specificity
35. Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system