Wingless-type frizzled protein receptor signaling and its putative role in human colon cancer

Molecular Carcinogenesis

Volumn 31, Issue 1, 2001, Pages 56-62

  Uthoff, Sonja M S ^a   Robert Eichenberger, M ^a   McAuliffe, Tracy L ^a   Hamilton, Crystal J ^a   Galandiuk, Susan ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Adenomatous polyposis coli; Beta catenin; Frizzled receptor signaling; Secreted apoptosis related proteins; T cell factor lymphoid enhancing factor; Wingless type proteins

Indexed keywords

APC PROTEIN; AXIN; BETA CATENIN; WNT PROTEIN;

ARTICLE; BINDING AFFINITY; COLON CANCER; COLON CARCINOGENESIS; GENETIC POLYMORPHISM; GENETIC STABILITY; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

COLORECTAL NEOPLASMS; CYTOSKELETAL PROTEINS; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 0035008166     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.1039     Document Type: Article

References (42)

1. The future of genetic studies of complex human diseases
2. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
3. Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability
4. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
5. A test for linkage and association in general pedigrees: The pedigree disequilibrium test
6. The TDT and other family-based tests for linkage disequilibrium and association
7. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled
8. Transformation by Wnt family proteins correlates with regulation of beta-catenin
9. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action
10. SARPs: A family of secreted apoptosis-related proteins
11. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene
12. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis
13. A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin
14. Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation
15. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
16. Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
17. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
18. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
19. Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
20. Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription
21. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
22. Identification and characterization of the familial adenomatous polyposis coli gene
23. Mutations in the APC gene and their implications for protein structure and function
24. The oncogenic activation of beta-catenin
25. Association of the APC gene product with beta-catenin
26. Association of the APC tumor suppressor protein with catenins
27. Down-regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin
28. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coil (APC) tumor-suppressor protein
29. Apc1638T: A mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development
30. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
31. Localization of the human beta-catenin gene (CTNNB1) to 3p21: A region implicated in tumor development
32. Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: Frequent mutations in endometrioid carcinomas
33. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas
34. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
35. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene
36. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
37. Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity
38. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/colon carcinoma
39. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors
40. Identification of c-MYC as a target of the APC pathway
41. Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
42. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells